CD8

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'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.
'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell.
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</StructureSection>
== 3D Structures of CD8 ==
== 3D Structures of CD8 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1cd8]] – hCD8 extracellular domain – human <BR />
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*CD8
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===CD8α===
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**[[1cd8]] – hCD8 extracellular domain – human <BR />
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[[2hp4]] - hCD8 extracellular domain (mutant) <BR />
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*CD8α
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[[1akj]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide <BR />
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-
[[3qzw]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + NEF peptide <BR />
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[[1bqh]] - mCD8 extracellular domain + class I MHC + β-2-microglobulin + VSV8 peptide - mouse<BR />
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[[3dmm]] - mCD8 extracellular domain + class I MHC + β-2-microglobulin + peptide <BR />
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-
[[1nez]] - mCD8 extracellular domain + class I MHC + β-2-microglobulin <BR />
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[[1q69]] - hCD8 residues 209-227 + Lck peptide - NMR<BR />
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[[2arj]] - rCD8 extracellular domain + antibody - rat <BR />
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[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR />
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===CD8α and CD8β===
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**[[2hp4]] - hCD8 extracellular domain (mutant) <BR />
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**[[1akj]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + HIV reverse transcriptase peptide <BR />
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**[[3qzw]] - hCD8 extracellular domain + class I MHC + β-2-microglobulin + NEF peptide <BR />
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**[[1bqh]] - mCD8 extracellular domain + class I MHC + β-2-microglobulin + VSV8 peptide - mouse<BR />
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**[[3dmm]] - mCD8 extracellular domain + class I MHC + β-2-microglobulin + peptide <BR />
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**[[1nez]] - mCD8 extracellular domain + class I MHC + β-2-microglobulin <BR />
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**[[1q69]] - hCD8 residues 209-227 + Lck peptide - NMR<BR />
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**[[2arj]] - rCD8 extracellular domain + antibody - rat <BR />
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**[[2q3a]] – CD8 extracellular domain – rhesus monkey <BR />
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[[2atp]] - mCD8 + CD8α CD8β linker<BR />
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*CD8α and CD8β
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[[3b9k]] - mCD8 + antibody <BR />
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**[[2atp]] - mCD8 + CD8α CD8β linker<BR />
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**[[3b9k]] - mCD8 + antibody <BR />
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}}
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[[Category: Topic Page]]

Revision as of 07:52, 20 November 2014

Structure of CD8α (grey and magenta) and CD8β (green and cyan) complex with antibody heavy chain (aqua and pink) and light chain (red and yellow) (PDB entry 3b9k)

Drag the structure with the mouse to rotate

3D Structures of CD8

Updated on 20-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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