Centromere protein

Function

Centromere proteins (CENP) X,S,W,T make up the kinetochore structure on chromatids where the spindle fibers attach during cell division to pull the chromatids apart.
• CENP-X is a component of the Fanconi Anemia core.
• CENP-B facilitates centromere formation.
• CENP-A is a component of modified nucleosome replacing hitone H3.
• CENP-E is a motor protein involved inchromosome movement.
• CENP-M is involved in the kinetochore assembly.

• Inner centromere protein (INCENP) is a component of the chromosomal passenger complex which regulates mitosis. INCENP are localized at the centromeres during mid-metaphase of the cell cycle.

Disease

Relevance

Structural highlights