Cyclin-dependent kinase
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *CDK2 | |
See [[Cell Division Protein Kinase 2]] | See [[Cell Division Protein Kinase 2]] | ||
| - | + | *CDK3 | |
| - | [[1fpz]] – hCDK3 (mutant) | + | **[[1fpz]] – hCDK3 (mutant) |
| - | + | *CDK4 | |
| - | [[2w96]], [[2w99]], [[2w9f]], [[2w9z]] – hCDK4 kinase domain + cyclin D1<br /> | + | **[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] – hCDK4 kinase domain + cyclin D1<br /> |
| - | [[3g33]] - hCDK4 + cyclin D3 | + | **[[3g33]] - hCDK4 + cyclin D3 |
| - | + | *CDK5 | |
| - | [[1h4l]] – hCDK5 + CDK5 activator<br /> | + | **[[1h4l]] – hCDK5 + CDK5 activator<br /> |
| - | [[1ung]], [[1unh]], [[1unl]] - hCDK5 (mutant) + CDK5 activator + inhibitor<br /> | + | **[[1ung]], [[1unh]], [[1unl]] - hCDK5 (mutant) + CDK5 activator + inhibitor<br /> |
| - | [[3o0g]] - hCDK5 + ATP analog + CDK5 activator<br /> | + | **[[3o0g]] - hCDK5 + ATP analog + CDK5 activator<br /> |
| - | + | *CDK6 | |
| - | [[1bi7]] – hCDK6 + multiple tumor suppressor<br /> | + | **[[1bi7]] – hCDK6 + multiple tumor suppressor<br /> |
| - | [[1bi8]], [[1blx]] – hCDK6 + CDK protein inhibitor<br /> | + | **[[1bi8]], [[1blx]] – hCDK6 + CDK protein inhibitor<br /> |
| - | [[1g3n]] – hCDK6 + cyclin D homolog + CDK protein inhibitor<br /> | + | **[[1g3n]] – hCDK6 + cyclin D homolog + CDK protein inhibitor<br /> |
| - | [[1jow]] – hCDK6 + V-cyclin<br /> | + | **[[1jow]] – hCDK6 + V-cyclin<br /> |
| - | [[3nup]], [[3nux]], [[4aua]], [[4ez5]] – hCDK6 + inhibitor<br /> | + | **[[3nup]], [[3nux]], [[4aua]], [[4ez5]] – hCDK6 + inhibitor<br /> |
| - | [[1xo2]], [[2f2c]], [[2euf]], [[4tth]] – hCDK6 + V-cyclin + inhibitor<br /> | + | **[[1xo2]], [[2f2c]], [[2euf]], [[4tth]] – hCDK6 + V-cyclin + inhibitor<br /> |
| - | + | *CDK7 | |
| - | [[1ua2]] – hCDK7<br /> | + | **[[1ua2]] – hCDK7<br /> |
| - | + | *CDK8 | |
| - | [[4g6l]] – hCDK8 + cyclin C <br /> | + | **[[4g6l]] – hCDK8 + cyclin C <br /> |
| - | [[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]] – hCDK8 + cyclin C + inhibitor<br /> | + | **[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]] – hCDK8 + cyclin C + inhibitor<br /> |
| - | [[4f7s]] – hCDK8 + cyclin C + phenylethyl-quinazolin-amine<br /> | + | **[[4f7s]] – hCDK8 + cyclin C + phenylethyl-quinazolin-amine<br /> |
| - | + | *CDK9 | |
| - | [[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br /> | + | **[[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br /> |
| - | [[3blq]] – hCDK9-P + cyclin T1 (mutant) + ATP<br /> | + | **[[3blq]] – hCDK9-P + cyclin T1 (mutant) + ATP<br /> |
| - | [[3lq5]], [[3my1]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCDK9-P + cyclin T1 (mutant) + inhibitor<br /> | + | **[[3lq5]], [[3my1]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCDK9-P + cyclin T1 (mutant) + inhibitor<br /> |
| - | [[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br /> | + | **[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br /> |
| - | [[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br /> | + | **[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br /> |
| - | [[4or5]], [[4ogr]] – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein<br /> | + | **[[4or5]], [[4ogr]] – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein<br /> |
| - | [[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br /> | + | **[[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br /> |
| - | + | *CDK12 | |
| - | [[4cjy]], [[4un0]] – hCDK12-P + cyclin K<br /> | + | **[[4cjy]], [[4un0]] – hCDK12-P + cyclin K<br /> |
| - | [[4nst]] – hCDK12-P + cyclin K + AlF3<br /> | + | **[[4nst]] – hCDK12-P + cyclin K + AlF3<br /> |
| - | [[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br /> | + | **[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br /> |
| - | + | *CDK16 | |
| - | + | ||
| - | + | ||
| + | **[[3mtl]] – hCDK16 (mutant) + indirubin<br /> | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:50, 20 November 2014
Template:STRUCTURE 3rgf
Cyclin-dependent kinase (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.
• For details on CDK2 see Cell Division Protein Kinase 2.
• CDK3 binds cyclin C and functions during the G1 phase.
• For details on CDK4 see Cyclin Dependent Kinase-4.
- CDK5 binds p53 and functions during transcription.
• CDK6 binds cyclin D and functions during the G1 phase.
• CDK7 may serve as a direct link between transcription regulation and the cell cycle.
• CDK8 binds cyclin C and functions during transcription.
• CDK12 phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation.
• CDK16 plays a role in vescicle-mdiated transport processes and exocytosis.
3D structures of cyclin-dependent kinase
Updated on 20-November-2014
