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== Beta-2-microglobulin==
== Beta-2-microglobulin==
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Beta-2 microglobulin is a 12 kDa protein sub-unit of the class I major histocompatibility complex. In dialysis patients, it has the propensity to form amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA).
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Beta-2 microglobulin is a structural protein sub-unit of the class I major histocompatibility complex. It has a molecular weight of approximately 12 kDa. In dialysis patients, it has the propensity to form amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA). The oligomerization mechanisms and fibrillation are of particular interest to the Vachet Research Group at the University of Massachusetts-Amherst.
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== Function ==
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== Disease ==
== Disease ==
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Structural effects of the various mutations and their oligomers
Structural effects of the various mutations and their oligomers
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== Structural highlights ==
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== Code to color a green scene ==
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Revision as of 16:56, 20 November 2014

Human Beta-2 microglobulin

Drag the structure with the mouse to rotate

Contents

Beta-2-microglobulin

Beta-2 microglobulin is a structural protein sub-unit of the class I major histocompatibility complex. It has a molecular weight of approximately 12 kDa. In dialysis patients, it has the propensity to form amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA). The oligomerization mechanisms and fibrillation are of particular interest to the Vachet Research Group at the University of Massachusetts-Amherst.

Disease

Aggregation Mechanism

Display Nick's Dimer, try to find the tetramer, and the hexameter

B2m Mutations

Structural effects of the various mutations and their oligomers

Code to color a green scene

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>


Useful Links

The Vachet Lab [1]

References

Proteopedia Page Contributors and Editors (what is this?)

Tyler Marcinko

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