Cyclophilin

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{{STRUCTURE_2x25| PDB=2x25 | SIZE=400| SCENE= |right|CAPTION=human Cyclophilin-A with acetyllysine, [[2x25]] }}
{{STRUCTURE_2x25| PDB=2x25 | SIZE=400| SCENE= |right|CAPTION=human Cyclophilin-A with acetyllysine, [[2x25]] }}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== Cyclophilin-A ===
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* Cyclophilin-A
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+
-
[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]] – hCyp-A – human<br />
+
-
[[1oca]] – hCyp-A - NMR<br />
+
-
[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br />
+
-
[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br />
+
-
[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
+
-
[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]] - hCyp-A+cyclosporin A derivative<br />
+
-
[[2rma]], [[2rmb]] - hCyp-A+cyclosporin A+cyclosporin A derivative<br />
+
-
[[1mf8]], [[1m63]] - hCyp-A+cyclosporin A+ calcineurin subunits A,B<br />
+
-
[[3odi]], [[3odl]] – hCyp-A+voclosporin<br />
+
-
[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br />
+
-
[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) – ''Rhesus macaque''<br />
+
-
[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br />
+
-
[[4dgd]] - RmCyp-A (mutant)<br />
+
-
[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
+
-
[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br />
+
-
[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
+
-
[[1vbs]], [[1vbt]] – hCyp-A+tetrapeptide<br />
+
-
[[1vdn]] – yCyp-A+peptidyl coumarin – yeast<br />
+
-
[[1ist]] – yCyp-A<br />
+
-
[[1w74]] – Cyp-A – ''Mycobacterium tuberculosis''<br />
+
-
[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br />
+
-
[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br />
+
-
[[2xgy]] – Cyp-A+RELIK capsid N-terminal - rabbit<br />
+
-
[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
+
-
[[3pmp]] - NpCyp-A + cyclosporin A<br />
+
-
[[3rdd]] – hCyp-A + inhibitor<br />
+
-
=== Cyclophilin-B ===
+
**[[2x25]], [[2x2a]], [[3k0m]], [[3k0n]], [[1w8l]], [[1w8m]], [[1w8v]], [[1rmh]], [[2cpl]] – hCyp-A – human<br />
 +
**[[1oca]] – hCyp-A - NMR<br />
 +
**[[3k0o]], [[3k0p]], [[3k0q]], [[3k0r]], [[2alf]] – hCyp-A (mutant)<br />
 +
**[[2a2c]], [[1cwa]], [[1cwb]], [[1cwc]], [[2x2c]] – hCyp-A+cyclosporin A<br />
 +
**[[3cys]] - hCyp-A+cyclosporin A - NMR<br />
 +
**[[1cwj]], [[1bck]], [[1cwi]], [[1cwo]], [[1cwf]], [[1cwh]], [[1cwk]], [[1cwl]], [[1cwm]], [[1mik]] - hCyp-A+cyclosporin A derivative<br />
 +
**[[2rma]], [[2rmb]] - hCyp-A+cyclosporin A+cyclosporin A derivative<br />
 +
**[[1mf8]], [[1m63]] - hCyp-A+cyclosporin A+ calcineurin subunits A,B<br />
 +
**[[3odi]], [[3odl]] – hCyp-A+voclosporin<br />
 +
**[[2x2d]], [[1m9c]], [[1m9d]], [[1m9e]], [[1m9f]], [[1m9x]], [[1m9y]], [[1awq]], [[1awr]], [[1aws]], [[1awt]], [[1awu]], [[1awv]], [[1ak4]], [[1fgl]] - hCyp-A+HIV-1 N-terminal capsid domain<br />
 +
**[[4dga]], [[4dgb]], [[4dgc]] - RmCyp-A+HIV-1 Cyp-binding domain capsid protein (mutant) – ''Rhesus macaque''<br />
 +
**[[4dge]] - RmCyp-A (mutant) +HIV-1 Cyp-binding domain capsid protein (mutant) <br />
 +
**[[4dgd]] - RmCyp-A (mutant)<br />
 +
**[[1zkf]] – hCyp-A+suc-AGPF-pNA<br />
 +
**[[1ynd]], [[1nmk]] – hCyp-A+ sanglifehrin<br />
 +
**[[2cyh]], [[3cyh]], [[4cyh]], [[5cyh]] - hCyp-A+dipeptide<br />
 +
**[[1vbs]], [[1vbt]] – hCyp-A+tetrapeptide<br />
 +
**[[1vdn]] – yCyp-A+peptidyl coumarin – yeast<br />
 +
**[[1ist]] – yCyp-A<br />
 +
**[[1w74]] – Cyp-A – ''Mycobacterium tuberculosis''<br />
 +
**[[1lop]] - EcCyp-A+peptidyl nitroanilide - ''Escherichia coli''<br />
 +
**[[1csa]] – EcCyp-A+ cyclosporin A – NMR<br />
 +
**[[2xgy]] – Cyp-A+RELIK capsid N-terminal - rabbit<br />
 +
**[[3o7t]] – NpCyp-A – ''Noniliophthora perniciosa''<br />
 +
**[[3pmp]] - NpCyp-A + cyclosporin A<br />
 +
**[[3rdd]] – hCyp-A + inhibitor<br />
-
[[3ich]] – hCyp-B<br />
+
* Cyclophilin-B
-
[[3ici]] - hCyp-B+calmegin fragment<br />
+
-
[[1v9t]] – EcCyp-B+peptidyl nitroanilide <br />
+
-
[[1vai]] - EcCyp-B+peptidyl coumarin<br />
+
-
[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
+
-
[[1j2a]] – EcCyp-B (mutant)<br />
+
-
=== Cyclophilin-C ===
+
**[[3ich]] – hCyp-B<br />
 +
**[[3ici]] - hCyp-B+calmegin fragment<br />
 +
**[[1v9t]] – EcCyp-B+peptidyl nitroanilide <br />
 +
**[[1vai]] - EcCyp-B+peptidyl coumarin<br />
 +
**[[1cyn]] – hCyp-B +cyclosporin A derivative<br />
 +
**[[1j2a]] – EcCyp-B (mutant)<br />
-
[[2esl]] - hCyp-C+cyclosporin A<br />
+
* Cyclophilin-C
-
[[2rmc]] - Cyp-C+cyclosporin A – mouse<br />
+
-
=== Cyclophilin-D ===
+
**[[2esl]] - hCyp-C+cyclosporin A<br />
 +
**[[2rmc]] - Cyp-C+cyclosporin A – mouse<br />
-
[[2bit]], [[3qyu]] – hCyp-D<br />
+
* Cyclophilin-D
-
[[2biu]] – hCyp-D+DMSO<br />
+
-
[[2z6w]] - hCyp-D+cyclosporin A<br />
+
-
[[3r49]], [[3r4g]], [[3r54]], [[3r56]], [[3r57]], [[3r59]], [[3rcf]], [[3rcg]], [[3rci]], [[3rck]], [[3rcl]], [[3rd9]], [[3rda]], [[3rdb]], [[3rdc]], [[4j58]], [[4j59]], [[4j5a]], [[4j5b]], [[4j5c]], [[4j5d]] – hCyp-D (mutant) + inhibitor<br />
+
-
=== Cyclophilin-E ===
+
**[[2bit]], [[3qyu]] – hCyp-D<br />
 +
**[[2biu]] – hCyp-D+DMSO<br />
 +
**[[2z6w]] - hCyp-D+cyclosporin A<br />
 +
**[[3r49]], [[3r4g]], [[3r54]], [[3r56]], [[3r57]], [[3r59]], [[3rcf]], [[3rcg]], [[3rci]], [[3rck]], [[3rcl]], [[3rd9]], [[3rda]], [[3rdb]], [[3rdc]], [[4j58]], [[4j59]], [[4j5a]], [[4j5b]], [[4j5c]], [[4j5d]] – hCyp-D (mutant) + inhibitor<br />
-
[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br />
+
* Cyclophilin-E
-
[[2r99]] - hCyp-E ABH-like domain<br />
+
-
[[2cqb]] – hCyp-E RNA recognition motif<br />
+
-
[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br />
+
-
[[2kyx]] – hCyp-E RRM domain – NMR<br />
+
-
[[3lpy]], [[3mdf]] - hCyp-E RRM domain<br />
+
-
=== Cyclophilin-G ===
+
**[[2kyx]], [[1zmf]] – hCyp-E PPIASE domain<br />
 +
**[[2r99]] - hCyp-E ABH-like domain<br />
 +
**[[2cqb]] – hCyp-E RNA recognition motif<br />
 +
**[[2ck1]], [[2cmt]] – Cyp-E – ''Schistosoma mansoni''<br />
 +
**[[2kyx]] – hCyp-E RRM domain – NMR<br />
 +
**[[3lpy]], [[3mdf]] - hCyp-E RRM domain<br />
-
[[2wfi]], [[2gw2]] - hCyp-G PPIASE domain<br />
+
* Cyclophilin-G
-
[[2wfj]] - hCyp-G PPIASE domain+cyclosporin A<br />
+
-
=== Cyclophilin-H ===
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**[[2wfi]], [[2gw2]] - hCyp-G PPIASE domain<br />
 +
**[[2wfj]] - hCyp-G PPIASE domain+cyclosporin A<br />
-
[[1mzw]] – hCyp-H+peptide<br />
+
* Cyclophilin-H
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=== Cyclophilin-J ===
+
**[[1mzw]] – hCyp-H+peptide<br />
-
[[2ok3]], [[1xyh]] - hCyp-J<br />
+
* Cyclophilin-J
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[[2oju]] - hCyp-J+cyclosporin A<br />
+
-
=== Cyclophilin-3 ===
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**[[2ok3]], [[1xyh]] - hCyp-J<br />
 +
**[[2oju]] - hCyp-J+cyclosporin A<br />
-
[[2igv]], [[2igw]], [[1e8k]] – CeCyp-3+dipeptide – ''Caenorhabditis elegans''<br />
+
* Cyclophilin-3
-
[[1dyw]] - CeCyp-3<br />
+
-
[[1e3b]] – CeCyp-3+AUP(ET)3<br />
+
-
=== Cyclophilin-5 ===
+
**[[2igv]], [[2igw]], [[1e8k]] – CeCyp-3+dipeptide – ''Caenorhabditis elegans''<br />
 +
**[[1dyw]] - CeCyp-3<br />
 +
**[[1e3b]] – CeCyp-3+AUP(ET)3<br />
-
[[1h0p]] – CeCyp-5 (mutant) <br />
+
* Cyclophilin-5
-
=== Cyclophilin-40===
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**[[1h0p]] – CeCyp-5 (mutant) <br />
-
[[1ihg]], [[1iip]] – Cyp-40 – bovine<br />
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* Cyclophilin-40
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=== Cyclophilin ===
+
**[[1ihg]], [[1iip]] – Cyp-40 – bovine<br />
-
[[3bo7]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''<br />
+
* Cyclophilin
-
[[2nul]] – EcCyp<br />
+
-
[[1clh]] – EcCyp – NMR<br />
+
-
[[1qoi]] – hCyp SNUCYP-20<br />
+
-
[[3k2c]] – Cyp – ''Encephalitozoon cuniculi''<br />
+
-
[[3eov]] - LdCyp+cyclosporin A – ''Leishmania donovani''<br />
+
-
[[3bt8]] – LdCyp<br />
+
-
[[2haq]] – LdCyp-A<br />
+
-
[[2hqj]] – Cyp – ''Leishmania major''<br />
+
-
[[3bkp]] – TgCyp<br />
+
-
[[2cfe]] – Cyp – ''Malassezia sympodialis''<br />
+
-
[[2c3b]] – Cyp – ''Aspergillus fumigatus''<br />
+
-
[[1z81]] – Cyp – ''Plasmodium Yoelli''<br />
+
-
[[1qng]] – PfCyp+cyclosporin A – ''Plasmodium falciparum''<br />
+
-
[[1qnh]] – PfCyp (mutant)+cyclosporin A<br />
+
-
[[1xo7]] – TcCyp – ''Trypanosoma cruzi''<br />
+
-
[[1xq7]] - TcCyp+cyclosporin A<br />
+
-
[[1a58]] - Cyp – ''Brugia malayi''<br />
+
-
[[2ko7]] – BpCyp+inhibitor – ''Burkholderia pseudomallei''<br />
+
-
[[2ke0]] – BpCyp – NMR
+
 +
**[[3bo7]] - TgCyp+cyclosporin A - ''Toxoplasma gondii''<br />
 +
**[[2nul]] – EcCyp<br />
 +
**[[1clh]] – EcCyp – NMR<br />
 +
**[[1qoi]] – hCyp SNUCYP-20<br />
 +
**[[3k2c]] – Cyp – ''Encephalitozoon cuniculi''<br />
 +
**[[3eov]] - LdCyp+cyclosporin A – ''Leishmania donovani''<br />
 +
**[[3bt8]] – LdCyp<br />
 +
**[[2haq]] – LdCyp-A<br />
 +
**[[2hqj]] – Cyp – ''Leishmania major''<br />
 +
**[[3bkp]] – TgCyp<br />
 +
**[[2cfe]] – Cyp – ''Malassezia sympodialis''<br />
 +
**[[2c3b]] – Cyp – ''Aspergillus fumigatus''<br />
 +
**[[1z81]] – Cyp – ''Plasmodium Yoelli''<br />
 +
**[[1qng]] – PfCyp+cyclosporin A – ''Plasmodium falciparum''<br />
 +
**[[1qnh]] – PfCyp (mutant)+cyclosporin A<br />
 +
**[[1xo7]] – TcCyp – ''Trypanosoma cruzi''<br />
 +
**[[1xq7]] - TcCyp+cyclosporin A<br />
 +
**[[1a58]] - Cyp – ''Brugia malayi''<br />
 +
**[[2ko7]] – BpCyp+inhibitor – ''Burkholderia pseudomallei''<br />
 +
**[[2ke0]] – BpCyp – NMR
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:45, 23 November 2014

Template:STRUCTURE 2x25

Cyclophilin (Cyp) binds cyclosporin. They are peptidylprolyl isomerases which catalyze the isomerisation of proline. The Cyp-A/cyclosporin A complex inhibits organ rejection. Cyp-D is a component of the mitochondria permeability pore. Rotamase such as FKBP is a prokaryotic Cyp which is not inhibited by cyclosporin but by FK-506 – an immunosuppressive drug.

3D Structures of Cyclophilin

Updated on 23-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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