C-X-C motif chemokine

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===CXCL2===
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*CXCL2
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[[3n52]] – mCXCL – mouse<br />
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**[[3n52]] – mCXCL – mouse<br />
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[[1mi2]] – mCXCL – NMR<br />
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**[[1mi2]] – mCXCL – NMR<br />
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===CXCL10===
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*CXCL10
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[[1lv9]] – hCXCL – human – NMR<br />
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**[[1lv9]] – hCXCL – human – NMR<br />
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[[1o7z]], [[1o7y]], [[1o80]] – hCXCL<br />
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**[[1o7z]], [[1o7y]], [[1o80]] – hCXCL<br />
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[[2r3z]] – mCXCL <br />
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**[[2r3z]] – mCXCL <br />
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===CXCL11===
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*CXCL11
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[[1rjt]] – hCXCL<br />
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**[[1rjt]] – hCXCL<br />
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===CXCL12 (Stromal Derived Factor 1)===
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*CXCL12 (Stromal Derived Factor 1)
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[[2kec]], [[2ked]], [[2kee]], [[2sdf]], [[1sdf]], [[1vmc]] - hSDF1α – NMR - human<br />
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**[[2kec]], [[2ked]], [[2kee]], [[2sdf]], [[1sdf]], [[1vmc]] - hSDF1α – NMR - human<br />
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[[1qg7]], [[3hp3]] - hSDF1α<br />
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**[[1qg7]], [[3hp3]] - hSDF1α<br />
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[[2k0l]], [[2k01]], [[2kol]] – hSDF1α (mutant) – NMR<br />
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**[[2k0l]], [[2k01]], [[2kol]] – hSDF1α (mutant) – NMR<br />
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[[1a15]], [[3gv3]] - hSDF1α (mutant)<br />
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**[[1a15]], [[3gv3]] - hSDF1α (mutant)<br />
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[[2nwg]] - hSDF1α+heparin<br />
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**[[2nwg]] - hSDF1α+heparin<br />
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[[2j7z]] - hSDF1α residues 22-89<br />
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**[[2j7z]] - hSDF1α residues 22-89<br />
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[[2k03]], [[2k04]], [[2k05]] - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)<br />
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**[[2k03]], [[2k04]], [[2k05]] - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)<br />
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[[4lmq]] - hSDF1α + immunoghlobulin heavy chain<br />
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**[[4lmq]] - hSDF1α + immunoghlobulin heavy chain<br />
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===CXCL14===
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*CXCL14
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[[2hdl]] – hCXCL – NMR<br />
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**[[2hdl]] – hCXCL – NMR<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:54, 23 November 2014

PDB ID 1qg7

Drag the structure with the mouse to rotate
CXCL12α dimer complex with sulfate, 1qg7
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



C-X-C motif chemokine (CXCL) are small chemokines.

• CXCL2 or MIP-2 or imacrophage inflammatory protein 2 acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.
• CXCL10 or IP-10 or interferon γ-induced protein 10 acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.
• CXCL11 or IP-9 or interferon γ-induced protein 9 acts as chemotactic for activated T cells.
• CXCL12 or Stromal-Derived-Factor-1 (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis.
• CXCL14 or BRAK acts as chemotactic for monocytes and inhibits angiogenesis.

3D Structures of C-X-C motif chemokine

Updated on 23-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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