Defensin

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==3D structures of defensin==
==3D structures of defensin==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===α-defensin===
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*α-defensin
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[[1ica]] – DEFA – ''Protophormia terraenovae''<BR />
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**[[1ica]] – DEFA – ''Protophormia terraenovae''<BR />
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[[1ews]] – DEFA RK-1 – rabbit – NMR<BR />
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**[[1ews]] – DEFA RK-1 – rabbit – NMR<BR />
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[[2k1i]] - RmDEFA – Rhesus macaque - NMR<BR />
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**[[2k1i]] - RmDEFA – Rhesus macaque - NMR<BR />
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[[1zmh]], [[1zmi]], [[1zmk]] - hDEFA HNP-2 (mutant) – human<BR />
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**[[1zmh]], [[1zmi]], [[1zmk]] - hDEFA HNP-2 (mutant) – human<BR />
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[[3gny]], [[3go0]], [[3hj2]] - hDEFA HNP-1<BR />
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**[[3gny]], [[3go0]], [[3hj2]] - hDEFA HNP-1<BR />
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[[2kht]] - hDEFA HNP-1 - NMR<BR />
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**[[2kht]] - hDEFA HNP-1 - NMR<BR />
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[[2pm1]], [[2pm4]], [[2pm5]], [[3hjd]], [[3h6c]], [[3lo1]], [[3lo2]], [[3lo4]], [[3lo6]], [[3lo8]], [[3loe]], [[3lvx]], [[4du0]], [[4lb1]], [[4lb7]], [[4lbb]], [[4lbf]] - hDEFA HNP-1 (mutant) <BR />
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**[[2pm1]], [[2pm4]], [[2pm5]], [[3hjd]], [[3h6c]], [[3lo1]], [[3lo2]], [[3lo4]], [[3lo6]], [[3lo8]], [[3loe]], [[3lvx]], [[4du0]], [[4lb1]], [[4lb7]], [[4lbb]], [[4lbf]] - hDEFA HNP-1 (mutant) <BR />
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[[1zmm]] – hDEFA4 <BR />
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**[[1zmm]] – hDEFA4 <BR />
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[[2lew]] – mDEFA4 (mutant) – mouse – NMR<br />
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**[[2lew]] – mDEFA4 (mutant) – mouse – NMR<br />
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[[2ley]] – mDEFA4 – NMR<br />
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**[[2ley]] – mDEFA4 – NMR<br />
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[[1zmp]] – hDEFA5<BR />
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**[[1zmp]] – hDEFA5<BR />
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[[2lxz]] – hDEFA5 – NMR<br />
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**[[2lxz]] – hDEFA5 – NMR<br />
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[[3i5w]], [[4e82]], [[4e83]], [[4e86]] – hDEFA5 (mutant) <BR />
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**[[3i5w]], [[4e82]], [[4e83]], [[4e86]] – hDEFA5 (mutant) <BR />
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[[1zmq]] – hDEFA6<BR />
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**[[1zmq]] – hDEFA6<BR />
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[[3qte]] – hDEFA6 (mutant)
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**[[3qte]] – hDEFA6 (mutant)
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===β-defensin===
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*β-defensin
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[[1iju]], [[1ijv]] – hDEFB1<BR />
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**[[1iju]], [[1ijv]] – hDEFB1<BR />
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[[2nlb]], [[2nld]], [[2nle]], [[2nlf]], [[2nlg]], [[2nlh]], [[2nlp]], [[2nlq]], [[2nls]], [[2plz]], [[2lwl]], [[2nlc]] - hDEFB1 (mutant) <BR />
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**[[2nlb]], [[2nld]], [[2nle]], [[2nlf]], [[2nlg]], [[2nlh]], [[2nlp]], [[2nlq]], [[2nls]], [[2plz]], [[2lwl]], [[2nlc]] - hDEFB1 (mutant) <BR />
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[[1e4s]], [[1kj5]] – hDEFB1 – NMR<BR />
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**[[1e4s]], [[1kj5]] – hDEFB1 – NMR<BR />
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[[1fd3]], [[1fd4]] – hDEFB2 <BR />
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**[[1fd3]], [[1fd4]] – hDEFB2 <BR />
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[[1fqq]], [[1e4q]] - hDEFB2 – NMR<BR />
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**[[1fqq]], [[1e4q]] - hDEFB2 – NMR<BR />
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[[2lg5]] - cDEFB2 – chicken – NMR<BR />
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**[[2lg5]] - cDEFB2 – chicken – NMR<BR />
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[[2lg6]] - cDEFB2 (mutant) – NMR<BR />
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**[[2lg6]] - cDEFB2 (mutant) – NMR<BR />
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[[1kj6]] – hDEFB3 – NMR<BR />
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**[[1kj6]] – hDEFB3 – NMR<BR />
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[[1e4t]] – mDEFB7 – NMR<BR />
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**[[1e4t]] – mDEFB7 – NMR<BR />
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[[1e4r]] - mDEFB8 – NMR<BR />
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**[[1e4r]] - mDEFB8 – NMR<BR />
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[[1bnb]] – DEFB12 – bovine – NMR<BR />
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**[[1bnb]] – DEFB12 – bovine – NMR<BR />
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===ϑ-defensin===
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*ϑ-defensin
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[[1hvz]] – RmDEF1 – NMR<BR />
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**[[1hvz]] – RmDEF1 – NMR<BR />
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===Other defensins===
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*Other defensins
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[[1dfn]] – hDEF HNP-3 <BR />
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[[1fjn]] – DEF MGD-1 – Mediterranean mussel<BR />
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[[1mr4]] – tDEF NAD1 – tobacco – NMR<BR />
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[[4aaz]], [[4ab0]] - tDEF NAD1<BR />
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[[1ozz]] – AdDEF ARD1 – ''Archaeoprepona demophon'' – NMR<BR />
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[[1p00]], [[1p0a]] - AdDEF ARD1 (mutant) – NMR<BR />
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[[1ti5]] - VrDEF – ''Vigna radiata'' – NMR<BR />
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[[2gl1]] – VrDEF2<BR />
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[[2b68]] - DEF – Pacific oyster – NMR<BR />
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[[2b5b]] - DEF – Loggerhead turtle – NMR<BR />
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[[2e3e]], [[2e3f]], [[2e3g]], [[2ny8]], [[2ny9]], [[2nz3]] - DEF (mutant) – Anopheles – NMR<BR />
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[[2rng]] - DEF – Horseshoe crab – NMR<BR />
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[[3psm]] – DEF – Potato bean<BR />
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[[2ksk]] – DEF5 – Sugarcane - NMR<BR />
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[[2lj7]] – DEF – lentil – NMR<br />
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[[2lr3]] – DEF – barrel medic – NMR<br />
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**[[1dfn]] – hDEF HNP-3 <BR />
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**[[1fjn]] – DEF MGD-1 – Mediterranean mussel<BR />
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**[[1mr4]] – tDEF NAD1 – tobacco – NMR<BR />
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**[[4aaz]], [[4ab0]] - tDEF NAD1<BR />
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**[[1ozz]] – AdDEF ARD1 – ''Archaeoprepona demophon'' – NMR<BR />
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**[[1p00]], [[1p0a]] - AdDEF ARD1 (mutant) – NMR<BR />
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**[[1ti5]] - VrDEF – ''Vigna radiata'' – NMR<BR />
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**[[2gl1]] – VrDEF2<BR />
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**[[2b68]] - DEF – Pacific oyster – NMR<BR />
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**[[2b5b]] - DEF – Loggerhead turtle – NMR<BR />
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**[[2e3e]], [[2e3f]], [[2e3g]], [[2ny8]], [[2ny9]], [[2nz3]] - DEF (mutant) – Anopheles – NMR<BR />
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**[[2rng]] - DEF – Horseshoe crab – NMR<BR />
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**[[3psm]] – DEF – Potato bean<BR />
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**[[2ksk]] – DEF5 – Sugarcane - NMR<BR />
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**[[2lj7]] – DEF – lentil – NMR<br />
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**[[2lr3]] – DEF – barrel medic – NMR<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:01, 23 November 2014

Template:STRUCTURE 2pm4

Defensins (DEF) are small cationic defense proteins active against bacteria, fungi and viruses. DEF contains 6-8 conserved cysteine residues. DEF binds to microbial cell membrane forming pores and thus allowing outflow of essential nutrients. There is increase in α-DEF in chronic inflammations and several cancers. For details on plant DEF see Plant defensin.

3D structures of defensin

Updated on 23-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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