1lof
From Proteopedia
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| - | [[Image:1lof.jpg|left|200px]] | + | [[Image:1lof.jpg|left|200px]] |
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| - | '''X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION''' | + | {{Structure |
| + | |PDB= 1lof |SIZE=350|CAPTION= <scene name='initialview01'>1lof</scene>, resolution 2.3Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=MN:MANGANESE (II) ION'>MN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LOF is a [ | + | 1LOF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Lathyrus_ochrus Lathyrus ochrus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOF OCA]. |
==Reference== | ==Reference== | ||
| - | X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:[http:// | + | X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1730588 1730588] |
[[Category: Lathyrus ochrus]] | [[Category: Lathyrus ochrus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:33:15 2008'' |
Revision as of 10:33, 20 March 2008
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| , resolution 2.3Å | |||||||
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| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION
Overview
The structure and flexibility of saccharides have a profound and specific influence in several biological processes such as protein protection and the maintenance of conformational integrity, and in recognition events involving viruses, enzymes, and lectins. To establish the structural bases of these phenomena, we describe herein the extensively refined 2.3-A resolution x-ray structure of a biantennary octasaccharide of the N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus. The two octasaccharides are located in clefts at each end of the long axis of the lectin. The conformations of both the lectin and the saccharide are slightly modified upon binding. The complex is stabilized by numerous hydrogen bonds, many of them involving water molecules. It is also stabilized by van der Waals interactions, including some with aromatic residues. A more general model of a possible lectin-glycoprotein interaction is also proposed.
About this Structure
1LOF is a Protein complex structure of sequences from Lathyrus ochrus. Full crystallographic information is available from OCA.
Reference
X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:1730588
Page seeded by OCA on Thu Mar 20 12:33:15 2008
Categories: Lathyrus ochrus | Protein complex | Bourne, Y. | Cambillau, C. | CA | GAL | MN | Lectin
