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DNA ligase
From Proteopedia
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A specific point mutation (46BR in the mouse Lig1 gene) in DNA ligase I has also been linked as a cause for genome instability and cancer in humans. One possible reason for this is the accumulation of DNA fragments that are no longer ligated by the mutant DNA ligase I enzyme. | A specific point mutation (46BR in the mouse Lig1 gene) in DNA ligase I has also been linked as a cause for genome instability and cancer in humans. One possible reason for this is the accumulation of DNA fragments that are no longer ligated by the mutant DNA ligase I enzyme. | ||
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== 3D Structures of DNA ligase == | == 3D Structures of DNA ligase == | ||
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**[[3w1b]], [[3w1g]] - hLigD IV + artemis protein peptide<br /> | **[[3w1b]], [[3w1g]] - hLigD IV + artemis protein peptide<br /> | ||
}} | }} | ||
| - | </StructureSection> | ||
==REFERENCES== | ==REFERENCES== | ||
Revision as of 09:07, 24 November 2014
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3D Structures of DNA ligase
Updated on 24-November-2014
REFERENCES
Elevated expression of DNA ligase I in human cancers., Sun DY, Urrabaz R, Nguyen M, Marty J, Stringer S, Cruz E, Medina-Gundrum L, Weitman S., Clinical Cancer Research. 2001; 7(12):4143-4148.
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene., Harrison C, Ketchen AM, Redhead NJ, O'Sullivan MJ, Melton DW., Cancer Research. 2002; 62(14):4065-4074.
- Created with the participation of Audrey Kuan.
