Dual specificity protein kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===CLK1===
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*CLK1
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[[1z57]] – hCLK1 kinase domain + himenialdizine – human
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**[[1z57]] – hCLK1 kinase domain + himenialdizine – human
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[[2vag]] - hCLK1 kinase domain + indole inhibitor
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**[[2vag]] - hCLK1 kinase domain + indole inhibitor
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===CLK2===
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*CLK2
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[[3nr9]] – hCLK2 kinase domain
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**[[3nr9]] – hCLK2 kinase domain
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===CLK3===
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*CLK3
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[[2eu9]] – hCLK3
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**[[2eu9]] – hCLK3
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[[2exe]] – hCLK3 kinase domain, phosphorylated
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**[[2exe]] – hCLK3 kinase domain, phosphorylated
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[[2wu6]], [[2wu7]] – hCLK3 kinase domain + inhibitor
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**[[2wu6]], [[2wu7]] – hCLK3 kinase domain + inhibitor
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[[3raw]] - hCLK3 kinase domain + leucettine
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**[[3raw]] - hCLK3 kinase domain + leucettine
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===TTK===
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*TTK
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[[3cek]], [[3dbq]] – hTTK kinase domain<br />
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**[[3cek]], [[3dbq]] – hTTK kinase domain<br />
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[[4b94]], [[4h7x]], [[4h7y]] - hTTK TPR domain<br />
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**[[4b94]], [[4h7x]], [[4h7y]] - hTTK TPR domain<br />
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[[3gfw]] - hTTK kinase domain + pyrolo-pyridin ligand
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**[[3gfw]] - hTTK kinase domain + pyrolo-pyridin ligand
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[[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand
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**[[3h9f]] - hTTK kinase domain + pyrimidino-diazepin ligand
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[[2x9e]], [[3vqu]], [[3w1f]], [[4bhz]], [[4bi0]], [[4bi1]], [[4bi2]], [[4c4e]], [[4c4f]], [[4c4g]], [[4c4h]], [[4c4i]], [[4c4j]], [[4js8]], [[4jt3]] - hTTK kinase domain + inhibitor
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**[[2x9e]], [[3vqu]], [[3w1f]], [[4bhz]], [[4bi0]], [[4bi1]], [[4bi2]], [[4c4e]], [[4c4f]], [[4c4g]], [[4c4h]], [[4c4i]], [[4c4j]], [[4js8]], [[4jt3]] - hTTK kinase domain + inhibitor
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[[2zmc]] - hTTK kinase domain
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**[[2zmc]] - hTTK kinase domain
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[[2zmd]] - hTTK kinase domain (mutant) + inhibitor
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**[[2zmd]] - hTTK kinase domain (mutant) + inhibitor
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[[3hmn]] - hTTK kinase domain + ATP
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**[[3hmn]] - hTTK kinase domain + ATP
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[[3hmo]] - hTTK kinase domain + staurosporine
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**[[3hmo]] - hTTK kinase domain + staurosporine
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[[3hmp]] - hTTK kinase domain + quinazolin ligand
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**[[3hmp]] - hTTK kinase domain + quinazolin ligand
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:41, 24 November 2014

Template:STRUCTURE 2x9e

Dual specificity protein kinases are kinases which act as both tyrosine kinase and serine/threonine kinase. CLK1 phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing. The dual specificity protein kinase TTK contains tetra-trico-peptide repeat domain (TPR) which serves as interaction domain between proteins.

3D structures of dual specificity protein kinase

Updated on 24-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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