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Exonuclease

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===ExN-I===
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*ExN-I
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[[1fxx]], [[3c95]] – EcExN-I – ''Escherichia coli''<br />
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-
[[2qxf]] - EcExN-I + TMP<br />
+
-
[[3hl8]], [[3hp9]] - EcExN-I + inhibitor<br />
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-
[[3c94]] - EcExN-I + DNA-binding C terminal peptide<br />
+
-
[[4jrp]], [[4jrq]] – EcExN-I + oligonucleotide<br />
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-
[[3qe9]] – hExN-I (mutant) + DNA – human<br />
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-
[[3qea]], [[3qeb]] - hExN-I + DNA
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-
===ExN-III===
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**[[1fxx]], [[3c95]] – EcExN-I – ''Escherichia coli''<br />
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**[[2qxf]] - EcExN-I + TMP<br />
 +
**[[3hl8]], [[3hp9]] - EcExN-I + inhibitor<br />
 +
**[[3c94]] - EcExN-I + DNA-binding C terminal peptide<br />
 +
**[[4jrp]], [[4jrq]] – EcExN-I + oligonucleotide<br />
 +
**[[3qe9]] – hExN-I (mutant) + DNA – human<br />
 +
**[[3qea]], [[3qeb]] - hExN-I + DNA
-
[[2voa]] – AfExN-III (mutant) + DNA – ''Archaeoglobus fulgidus''<br />
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*ExN-III
-
[[3g1k]] - MtExN-III – ''Methanothermobacter thermaautotrophicus''<br />
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-
[[3g3c]], [[3g4t]] - MtExN-III + DNA<br />
+
-
[[3fzi]], [[3g8v]], [[3g91]] - MtExN-III (mutant) <br />
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-
[[3g00]], [[3g0r]], [[3g2c]], [[3g2d]], [[3g38]], [[3g3y]], [[3ga6]] - MtExN-III (mutant) + DNA<br />
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-
[[3g0a]] - MtExN-III (mutant) + Mn<br />
+
-
[[1ako]] – EcExN-III
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-
===ExN-IV===
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**[[2voa]] – AfExN-III (mutant) + DNA – ''Archaeoglobus fulgidus''<br />
 +
**[[3g1k]] - MtExN-III – ''Methanothermobacter thermaautotrophicus''<br />
 +
**[[3g3c]], [[3g4t]] - MtExN-III + DNA<br />
 +
**[[3fzi]], [[3g8v]], [[3g91]] - MtExN-III (mutant) <br />
 +
**[[3g00]], [[3g0r]], [[3g2c]], [[3g2d]], [[3g38]], [[3g3y]], [[3ga6]] - MtExN-III (mutant) + DNA<br />
 +
**[[3g0a]] - MtExN-III (mutant) + Mn<br />
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**[[1ako]] – EcExN-III
-
[[2jc4]] – ExN-IV – ''Nisseria meningitides''
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*ExN-IV
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===ExN-V===
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**[[2jc4]] – ExN-IV – ''Nisseria meningitides''
-
[[1w36]], [[3k70]] – EcExN-V α+β+γ + DNA hairpin<br />
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*ExN-V
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[[3e1s]] - EcExN-V RECD subunit<br />
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-
[[3gp8]] - DrExN-V RECD subunit + DNA – ''Deinococcus radiodurans''<br />
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-
[[3gpl]] - DrExN-V RECD subunit + DNA + ADPNP
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-
===ExN-VII===
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**[[1w36]], [[3k70]] – EcExN-V α+β+γ + DNA hairpin<br />
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**[[3e1s]] - EcExN-V RECD subunit<br />
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**[[3gp8]] - DrExN-V RECD subunit + DNA – ''Deinococcus radiodurans''<br />
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**[[3gpl]] - DrExN-V RECD subunit + DNA + ADPNP
-
[[1vp7]] – ExN-VII small subunit – ''Bordetella pertussis''
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*ExN-VII
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===ExN-VIII===
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**[[1vp7]] – ExN-VII small subunit – ''Bordetella pertussis''
-
[[3h4r]] - EcExN-VIII C terminal (mutant)
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*ExN-VIII
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===Phage ExN===
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**[[3h4r]] - EcExN-VIII C terminal (mutant)
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[[1ut5]], [[1ut8]] – T5-5’-ExN + metal – Bacteriophage T5<br />
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*Phage ExN
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[[1exn]], [[1xo1]] - T5-5’-ExN (mutant)<br />
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-
[[1avq]] – BlExN λ (mutant) – Bacteriophage λ<br />
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-
[[3slp]] - BlExN λ + DNA<br />
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-
[[3sm4]] - BlExN λ (mutant) + DNA<br />
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[[3k93]] – ExN – Haemophilus somnus
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===Exosome complex ExN===
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**[[1ut5]], [[1ut8]] – T5-5’-ExN + metal – Bacteriophage T5<br />
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**[[1exn]], [[1xo1]] - T5-5’-ExN (mutant)<br />
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**[[1avq]] – BlExN λ (mutant) – Bacteriophage λ<br />
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**[[3slp]] - BlExN λ + DNA<br />
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**[[3sm4]] - BlExN λ (mutant) + DNA<br />
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**[[3k93]] – ExN – Haemophilus somnus
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[[2ba1]] – AfExN Rrp41<br />
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*Exosome complex ExN
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[[2br2]] – SsExN-I + ExN-II – ''Sulfolobus solfataricus''<br />
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-
[[2jea]], [[2je6]], [[2jeb]] - SsExN-I (mutant) + ExN-II + RNA-binding protein 1<br />
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-
[[2hbj]], [[2hbk]], [[2hbl]], [[2hbm]] – yExN Rrp6 (mutant) <br />
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-
[[2ja9]] – yExN Rrp40<br />
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-
[[2vnu]] – yExN Rrp44 + DNA<br />
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[[2wp8]] - yExN Rrp45, Ski6, Dis3<br />
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[[2ioc]] - hExN Trex1 N terminal<br />
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-
[[2nn6]] – hExN Rrp41, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4<br />
+
-
[[4ifd]] - yExN Rrp6, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4, Rrp6, Ski6, Dis3 + RNA<br />
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===Various ExN===
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**[[2ba1]] – AfExN Rrp41<br />
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**[[2br2]] – SsExN-I + ExN-II – ''Sulfolobus solfataricus''<br />
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**[[2jea]], [[2je6]], [[2jeb]] - SsExN-I (mutant) + ExN-II + RNA-binding protein 1<br />
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**[[2hbj]], [[2hbk]], [[2hbl]], [[2hbm]] – yExN Rrp6 (mutant) <br />
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**[[2ja9]] – yExN Rrp40<br />
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**[[2vnu]] – yExN Rrp44 + DNA<br />
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**[[2wp8]] - yExN Rrp45, Ski6, Dis3<br />
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**[[2ioc]] - hExN Trex1 N terminal<br />
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**[[2nn6]] – hExN Rrp41, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4<br />
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**[[4ifd]] - yExN Rrp6, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4, Rrp6, Ski6, Dis3 + RNA<br />
-
[[1ir6]], [[2zxo]], [[2zxp]], [[2zxr]] – ExN Recj – ''Thermus thermophiles''<br />
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*Other ExN
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[[1w0h]] – hExn Eri1 nuclease domain <br />
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-
[[1zbu]] - hExn Eri1<br />
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[[1zbh]] - hExn Eri1 (mutant) + DNA<br />
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[[1y97]] – hExN Trex2<br />
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[[3zdk]] – hExN Apollo<br />
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[[2o4g]] - mExN Trex1 + nucleotide – mouse<br />
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-
[[3mxj]] - mExN Trex1<br />
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-
[[2o4i]], [[3mxi]], [[3mxm]], [[3u3y]], [[3u6f]] - mExN Trex1 (mutant) + polynucleotide<br />
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[[2oa8]] - mExN Trex1 + DNA<br />
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-
[[3b6o]], [[3b6p]] - mExN Trex1 + ion inhibitor<br />
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[[2w45]] – H4ExN alkaline - Herpesvirus 4<br />
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[[2w4b]] - H4ExN alkaline (mutant)<br />
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[[3syy]] - LhExN alkaline – ''Laribacter hongkongensis''<br />
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[[3sz4]] - LhExN alkaline + AMP<br />
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-
[[3sz5]] - LhExN alkaline + polynucleotide<br />
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[[3e2v]] – yExN - yeast
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**[[1ir6]], [[2zxo]], [[2zxp]], [[2zxr]] – ExN Recj – ''Thermus thermophiles''<br />
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**[[1w0h]] – hExn Eri1 nuclease domain <br />
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**[[1zbu]] - hExn Eri1<br />
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**[[1zbh]] - hExn Eri1 (mutant) + DNA<br />
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**[[1y97]] – hExN Trex2<br />
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**[[3zdk]] – hExN Apollo<br />
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**[[2o4g]] - mExN Trex1 + nucleotide – mouse<br />
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**[[3mxj]] - mExN Trex1<br />
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**[[2o4i]], [[3mxi]], [[3mxm]], [[3u3y]], [[3u6f]] - mExN Trex1 (mutant) + polynucleotide<br />
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**[[2oa8]] - mExN Trex1 + DNA<br />
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**[[3b6o]], [[3b6p]] - mExN Trex1 + ion inhibitor<br />
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**[[2w45]] – H4ExN alkaline - Herpesvirus 4<br />
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**[[2w4b]] - H4ExN alkaline (mutant)<br />
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**[[3syy]] - LhExN alkaline – ''Laribacter hongkongensis''<br />
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**[[3sz4]] - LhExN alkaline + AMP<br />
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**[[3sz5]] - LhExN alkaline + polynucleotide<br />
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**[[3e2v]] – yExN - yeast
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:59, 24 November 2014

Template:STRUCTURE 1fxx

Exonucleases (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII.

  • ExN-I cleaves single-stranded DNA.
  • ExN-II is associated with DNA polymerase.
  • ExN-III cleaves double-stranded DNA.
  • ExN-IV cleavage results in nucleoside monophosphate.
  • ExN-V cleaves linear double-stranded DNA.
  • ExN-VIII requires a free 5’ OH group for reacting.
  • ExN were found in human and yeast as well.

3D Structures of exonuclease

Updated on 24-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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