This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Factor inhibiting HIF

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 6: Line 6:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===FIH1α===
+
*FIH1α
-
[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
+
**[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
-
===FIH1α complex with small molecule===
+
*FIH1α complex with small molecule
-
[[1yci]], [[3od4]], [[2yc0]], [[2yde]]– hFIH1α + inhibitor<br />
+
**[[1yci]], [[3od4]], [[2yc0]], [[2yde] – hFIH1α + inhibitor<br />
-
[[2w0x]] - hFIH1α + pyridine derivative<br />
+
**[[2w0x]] - hFIH1α + pyridine derivative<br />
-
[[2cgn]] – hFIH1α + succinate<br />
+
**[[2cgn]] – hFIH1α + succinate<br />
-
[[2cgo]] – hFIH1α + fumarate<br />
+
**[[2cgo]] – hFIH1α + fumarate<br />
-
[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />
+
**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />
-
[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
+
**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
-
[[4ai8]] - hFIH1α + daminozide<br />
+
**[[4ai8]] - hFIH1α + daminozide<br />
-
===FIH1α complex with polypeptide===
+
*FIH1α complex with polypeptide
-
[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
+
**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
-
[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
+
**[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
-
[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
+
**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
-
[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
+
**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
-
[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
+
**[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
-
[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
+
**[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
-
[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
+
**[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
-
[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
+
**[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
-
[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />
+
**[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />
-
[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
+
**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
-
[[4b7e]], [[4b7k]], [[4jaa]] - hFIH1α + consensus ankyrin repeat peptide<br />
+
**[[4b7e]], [[4b7k]], [[4jaa]] - hFIH1α + consensus ankyrin repeat peptide<br />
-
===FIH2α===
+
*FIH2α
-
[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
+
**[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
-
[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
+
**[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
-
===FIH1β===
+
*FIH1β
-
 
+
-
[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
+
-
[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR
+
 +
**[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
 +
**[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 13:13, 24 November 2014

Template:STRUCTURE 1mzf

For details on Factor inhibiting HIF see Molecular Playground/FIH. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.

3D Structures of factor inhibiting HIF

Updated on 24-November-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

  • FIH1α
  • FIH1α complex with small molecule
  • FIH1α complex with polypeptide
    • 1h2k, 1h2l, 1h2m – hFIH1α + HIF transactivation domain peptide
    • 2ilm, 3d8c - hFIH1α (mutant) + HIF peptide + α-ketoglutarate
    • 3p3n, 3p3p - hFIH1α + Notch 1 peptide
    • 2xum - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative
    • 2y0i - hFIH1α + tankyrase 2 peptide
    • 3hqr, 3hqu - hFIH 1α C terminal + EGL nine homolog
    • 1lqb, 1lm8 - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL
    • 1l3e - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR
    • 1l8c - hFIH 1α C terminal + CREB-binding protein zinc finger
    • 4h6j - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator
    • 4b7e, 4b7k, 4jaa - hFIH1α + consensus ankyrin repeat peptide
  • FIH2α
    • 2a24, 3f1n, 3f1o, 3f1p, 3h7w - hFIH 2α PAS domain + hFIH 1β PAS domain
    • 3h82 - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
  • FIH1β

}}

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Factor_inhibiting_HIF"
Personal tools