1lq8

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[[Image:1lq8.gif|left|200px]]<br /><applet load="1lq8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lq8.gif|left|200px]]
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caption="1lq8, resolution 2.40&Aring;" />
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'''Crystal structure of cleaved protein C inhibitor'''<br />
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{{Structure
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|PDB= 1lq8 |SIZE=350|CAPTION= <scene name='initialview01'>1lq8</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of cleaved protein C inhibitor'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LQ8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=IPA:'>IPA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQ8 OCA].
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1LQ8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQ8 OCA].
==Reference==
==Reference==
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Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation., Huntington JA, Kjellberg M, Stenflo J, Structure. 2003 Feb;11(2):205-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12575940 12575940]
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Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation., Huntington JA, Kjellberg M, Stenflo J, Structure. 2003 Feb;11(2):205-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12575940 12575940]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: serpin]]
[[Category: serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:47:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:33:53 2008''

Revision as of 10:33, 20 March 2008

Image:1lq8.gif


PDB ID 1lq8

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Crystal structure of cleaved protein C inhibitor


Contents

Overview

Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In blood it acts as a procoagulant, and, in the seminal vesicles, it is required for spermatogenesis. The activity of PCI is affected by heparin binding in a manner unique among the heparin binding serpins, and, in addition, PCI binds hydrophobic hormones with apparent specificity for retinoids. Here we present the 2.4 A crystallographic structure of reactive center loop (RCL) cleaved PCI. A striking feature of the structure is a two-turn N-terminal shortening of helix A, which creates a large hydrophobic pocket that docking studies indicate to be the retinoid binding site. On the basis of surface electrostatic properties, a novel mechanism for heparin activation is proposed.

Disease

Known diseases associated with this structure: Protein C inhibitor deficiency OMIM:[601841]

About this Structure

1LQ8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation., Huntington JA, Kjellberg M, Stenflo J, Structure. 2003 Feb;11(2):205-15. PMID:12575940

Page seeded by OCA on Thu Mar 20 12:33:53 2008

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