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Fibrinogen

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{{STRUCTURE_1n73| PDB=1n73 | SIZE=350| SCENE= |right|CAPTION=Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion,[[1n73]].}}
{{STRUCTURE_1n73| PDB=1n73 | SIZE=350| SCENE= |right|CAPTION=Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion,[[1n73]].}}
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Fibrinogen α+β+γ chains===
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*Fibrinogen α+β+γ chains
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[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human<br />
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[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
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[[2xnx]], [[2xny]] - hFba+hFbb+hFbg + M1 protein<br />
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[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
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[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
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[[1jy3]], [[1deq]] – cFba+cFbb+cFbg – cow<br />
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[[1jy2]] - cFba+cFbb+cFbg proteolytic fragment<br />
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[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
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[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
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[[1ei3]] - heFba+heFbb+heFbg<br />
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===Fibrinogen α chain===
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**[[3hus]], [[3h32]], [[3e1i]], [[3bvh]], [[2hlo]], [[2hod]], [[2hpc]], [[2oyh]], [[2oyi]], [[2h43]], [[2ffd]], [[1re3]], [[1rf1]], [[1n86]], [[1ltj]] – hFba+hFbb+hFbg+peptide ligand – human<br />
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**[[3ghg]], [[2q9i]], [[2z4e]] - hFba+hFbb+hFbg+knob A & B<br />
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**[[2xnx]], [[2xny]] - hFba+hFbb+hFbg + M1 protein<br />
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**[[2a45]] - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor<br />
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**[[1re4]], [[1rf0]], [[1n8e]], [[1lt9]] - hFba+hFbb+hFbg<br />
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**[[1jy3]], [[1deq]] – cFba+cFbb+cFbg – cow<br />
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**[[1jy2]] - cFba+cFbb+cFbg proteolytic fragment<br />
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**[[1n73]], [[1lwu]] - Fba+Fbb+Fbg+peptide ligand – Sea lamprey<br />
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**[[1m1j]] - heFba+heFbb+heFbg+peptide ligand – hen<br />
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**[[1ei3]] - heFba+heFbb+heFbg<br />
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[[1fzd]] – hFba EC domain<br />
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*Fibrinogen α chain
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[[1bbr]] – hFba+cε-thrombin<br />
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[[2jor]] – cFba – NMR<br />
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[[2baf]] – cFba<br />
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===Fibrinogen β chain===
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**[[1fzd]] – hFba EC domain<br />
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**[[1bbr]] – hFba+cε-thrombin<br />
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**[[2jor]] – cFba – NMR<br />
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**[[2baf]] – cFba<br />
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[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
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*Fibrinogen β chain
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[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />
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===Fibrinogen γ chain===
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**[[1fzf]], [[1fzg]] – hFb fragment double-D +peptide ligand<br />
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**[[1fze]], [[1fza]], [[1fzb]] – hFb fragment D<br />
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[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
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*Fibrinogen γ chain
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[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
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[[2fib]], 3fib - hFbg+peptide ligand<br />
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[[1fib]] – hFbg+Ca<br />
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[[1fic]], [[1fid]] – hFbg<br />
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[[3fib]] – hFbg C terminal<br />
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[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
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[[2hwl]] – hFbg peptide+prothrombin<br />
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[[2y7l]] – hFbg + agglutinin-like protein <br />
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**[[2vr3]] – hFbg+SaClumping Factor A – ''Staphylococcus aureus''<br />
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**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains<br />
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**[[2fib]], [[3fib]] - hFbg+peptide ligand<br />
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**[[1fib]] – hFbg+Ca<br />
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**[[1fic]], [[1fid]] – hFbg<br />
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**[[3fib]] – hFbg C terminal<br />
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**[[1dug]] – Fbg C-terminal/glutathione S-transferase – ''Schistosoma japonicum''<br />
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**[[2hwl]] – hFbg peptide+prothrombin<br />
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**[[2y7l]] – hFbg + agglutinin-like protein <br />
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}}
==References==
==References==
<references />
<references />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:34, 25 November 2014

Template:STRUCTURE 1n73

Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. [1] It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. [2] Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).

3D Structure of Fibrinogen

Updated on 25-November-2014

References

  1. ↑ Betts L, Merenbloom BK, Lord ST. The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE. J Thromb Haemost. 2006 May;4(5):1139-41. PMID:16689770 doi:10.1111/j.1538-7836.2006.01902.x
  2. ↑ Muszbek L, Bagoly Z, Bereczky Z, Katona E. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):190-205. PMID:18673233

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, David Canner, Mark Hoelzer, Alexander Berchansky, Angel Herraez

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