Fibroblast growth factor receptor

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===FGFR1===
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*FGFR1
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''FGFR1 tyrosine kinase domain''
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*''FGFR1 tyrosine kinase domain''
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[[1fgk]], [[3kxx]], [[3ky2]] – hFGFR1 TKD (mutant) - human <br />
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**[[1fgk]], [[3kxx]], [[3ky2]] – hFGFR1 TKD (mutant) - human <br />
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[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]] – hFGFR1 TKD (mutant) + inhibitor <br />
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**[[1agw]], [[1fgi]], [[2fgi]], [[3c4f]], [[3js2]], [[3rhx]], [[4f63]], [[4f64]], [[4f65]], [[3tt0]], [[4nk9]], [[4nka]], [[4nks]] – hFGFR1 TKD (mutant) + inhibitor <br />
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[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br />
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**[[3krj]] – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor <br />
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[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br />
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**[[1xr0]] – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR<br />
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[[3gqi]] – hFGFR1 TKD (mutant) with PTR + ACP <br />
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**[[3gqi]] – hFGFR1 TKD (mutant) with PTR + ACP <br />
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[[3gql]] – hFGFR1 TKD (mutant) + substrate <br />
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**[[3gql]] – hFGFR1 TKD (mutant) + substrate <br />
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''FGFR1 ligand-binding domain''
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*''FGFR1 ligand-binding domain''
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[[2cr3]] – hFGFR1 LBD D1 - NMR<br />
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**[[2cr3]] – hFGFR1 LBD D1 - NMR<br />
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[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br />
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**[[2ckn]] – FGFR1 LBD D1 – mouse - NMR<br />
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''FGFR1 complex with FGF''
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*''FGFR1 complex with FGF''
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[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br />
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**[[3ojv]] – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human <br />
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[[1cvs]] – hFGFR1 LBD D2,D3 (mutant) + hFGF2 (mutant) <br />
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**[[1cvs]] – hFGFR1 LBD D2,D3 (mutant) + hFGF2 (mutant) <br />
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[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br />
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**[[1evt]] – hFGFR1 LBD D2,D3 + hFGF1 <br />
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[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br />
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**[[1fq9]] – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS<br />
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===FGFR2===
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*FGFR2
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''FGFR2 tyrosine kinase domain''
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*''FGFR2 tyrosine kinase domain''
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[[1gjo]], [[1oec]], [[2psq]] – hFGFR2 TKD <br />
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**[[1gjo]], [[1oec]], [[2psq]] – hFGFR2 TKD <br />
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[[2pvy]], [[2pwl]], [[2py3]], [[2pz5]], [[2pzp]], [[2pzr]], [[2q0b]], [[4j95]], [[4j96]], [[4j97]], [[4j98]], [[4j99]] – hFGFR2 TKD (mutant) + ACP<br />
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**[[2pvy]], [[2pwl]], [[2py3]], [[2pz5]], [[2pzp]], [[2pzr]], [[2q0b]], [[4j95]], [[4j96]], [[4j97]], [[4j98]], [[4j99]] – hFGFR2 TKD (mutant) + ACP<br />
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[[3b2t]] – hFGFR2 TKD (mutant) + adenosine derivative<br />
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**[[3b2t]] – hFGFR2 TKD (mutant) + adenosine derivative<br />
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[[2pvf]] – hFGFR2 TKD with PTR + ACP + substrate peptide<br />
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**[[2pvf]] – hFGFR2 TKD with PTR + ACP + substrate peptide<br />
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[[3cly]] – hFGFR2 TKD (mutant) with PTR + ACP <br />
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**[[3cly]] – hFGFR2 TKD (mutant) with PTR + ACP <br />
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[[3ri1]] – hFGFR2 TKD + inhibitor<br />
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**[[3ri1]] – hFGFR2 TKD + inhibitor<br />
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''FGFR2 ligand-binding domain''
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*''FGFR2 ligand-binding domain''
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[[3dar]], [[3caf]], [[3euu]] – hFGFR2 LBD D2 <br />
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**[[3dar]], [[3caf]], [[3euu]] – hFGFR2 LBD D2 <br />
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[[1wvz]] – hFGFR2 LBD D2 - NMR<br />
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**[[1wvz]] – hFGFR2 LBD D2 - NMR<br />
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[[4hwu]] – hFGFR2 LBD D1 <br />
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**[[4hwu]] – hFGFR2 LBD D1 <br />
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''FGFR2 complex with FGF''
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*''FGFR2 complex with FGF''
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[[1e0o]] – hFGFR2 (mutant) LBD D2,D3 + hFGF1 (mutant) + HS<br />
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**[[1e0o]] – hFGFR2 (mutant) LBD D2,D3 + hFGF1 (mutant) + HS<br />
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[[3oj2]], [[3ojm]] – hFGFR2 (mutant) LBD D2,D3 + hFGF1 <br />
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**[[3oj2]], [[3ojm]] – hFGFR2 (mutant) LBD D2,D3 + hFGF1 <br />
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[[1djs]] – hFGFR2 LBD D2,D3 (mutant) + hFGF1 <br />
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**[[1djs]] – hFGFR2 LBD D2,D3 (mutant) + hFGF1 <br />
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[[1ev2]], [[1ii4]], [[1iil]] – hFGFR2 LBD D2,D3 + hFGF2 (mutant) <br />
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**[[1ev2]], [[1ii4]], [[1iil]] – hFGFR2 LBD D2,D3 + hFGF2 (mutant) <br />
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[[4j23]] – hFGFR2 LBD D2,D3 (mutant) + hFGF2 (mutant) + inhibitor <br />
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**[[4j23]] – hFGFR2 LBD D2,D3 (mutant) + hFGF2 (mutant) + inhibitor <br />
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[[3cu1]] – hFGFR2 LBD D2 + hFGF1 <br />
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**[[3cu1]] – hFGFR2 LBD D2 + hFGF1 <br />
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[[2fdb]] – hFGFR2 LBD D2,D3 + hFGF8b <br />
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**[[2fdb]] – hFGFR2 LBD D2,D3 + hFGF8b <br />
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[[1nun]] – hFGFR2 LBD D2,D3 + hFGF10 <br />
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**[[1nun]] – hFGFR2 LBD D2,D3 + hFGF10 <br />
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===FGFR3===
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*FGFR3
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[[3grw]] – hFGFR3 LBD D2,D3 + antibody<br />
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**[[3grw]] – hFGFR3 LBD D2,D3 + antibody<br />
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[[2lzl]] – hFGFR3 residues 357-399 – NMR<br />
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**[[2lzl]] – hFGFR3 residues 357-399 – NMR<br />
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[[4k33]] – hFGFR3 kinase domain (mutant)<br />
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**[[4k33]] – hFGFR3 kinase domain (mutant)<br />
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''FGFR3 complex with FGF''
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*''FGFR3 complex with FGF''
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[[1ry7]] – hFGFR3 LBD + hFGF1<br />
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**[[1ry7]] – hFGFR3 LBD + hFGF1<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:48, 25 November 2014

Template:STRUCTURE 1evt

Fibroblast growth factor receptors (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation.

3D structures of fibroblast growth factor receptor

Updated on 25-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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