Molecular Playground/CLOCK:BMAL1 heterodimer complex
From Proteopedia
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==CLOCK== | ==CLOCK== | ||
| - | CLOCK is a protein central to the regulation of the mammalian circadian rhythm system. CLOCK regulates the circadian rhythm by forming heterodimers with other circadian rhythm proteins to activate the transcription of other proteins. | + | CLOCK is a protein central to the regulation of the mammalian circadian rhythm system. CLOCK is a helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) protein that regulates the circadian rhythm by forming heterodimers with other circadian rhythm proteins to activate the transcription of other proteins. |
<ref>DOI:10.1126/science.280.5369.1564</ref> | <ref>DOI:10.1126/science.280.5369.1564</ref> | ||
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== Circadian Rhythm == | == Circadian Rhythm == | ||
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| + | The circadian rhythm is the 24 hour protein regulation system found in most mammalian species. The circadian rhythm causes certain proteins to be expressed during the day and then downregulated during the night. The circadian rhythm originates in the suprachiasmatic nucleus (SCN), which is located in the hypothalamus. The SCN controls the expression of of proteins in a time dependent manner through a genetic feedback loop initiated by light passing through the eye. | ||
<ref>DOI: 10.1126/science.1222804</ref> | <ref>DOI: 10.1126/science.1222804</ref> | ||
== Disease == | == Disease == | ||
Revision as of 16:46, 25 November 2014
CLOCK:BMAL1 heterodimer complex
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References
- ↑ doi: https://dx.doi.org/10.1126/science.280.5369.1564
- ↑ Huang N, Chelliah Y, Shan Y, Taylor CA, Yoo SH, Partch C, Green CB, Zhang H, Takahashi JS. Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science. 2012 Jul 13;337(6091):189-94. Epub 2012 May 31. PMID:22653727 doi:10.1126/science.1222804
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