1lti

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1lti.jpg|left|200px]]<br /><applet load="1lti" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1lti.jpg|left|200px]]
-
caption="1lti, resolution 2.13&Aring;" />
+
 
-
'''HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN'''<br />
+
{{Structure
 +
|PDB= 1lti |SIZE=350|CAPTION= <scene name='initialview01'>1lti</scene>, resolution 2.13&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1LTI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=GAL:'>GAL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA].
+
1LTI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTI OCA].
==Reference==
==Reference==
-
Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli., van den Akker F, Steensma E, Hol WG, Protein Sci. 1996 Jun;5(6):1184-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8762150 8762150]
+
Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli., van den Akker F, Steensma E, Hol WG, Protein Sci. 1996 Jun;5(6):1184-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8762150 8762150]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 19: Line 28:
[[Category: enterotoxin]]
[[Category: enterotoxin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:48:19 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:35:02 2008''

Revision as of 10:35, 20 March 2008

Image:1lti.jpg


PDB ID 1lti

Drag the structure with the mouse to rotate
, resolution 2.13Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN


Overview

Heat-labile enterotoxin (LT) is part of the cholera toxin (CT) family and consists of a catalytic A subunit and a B pentamer that serves to recognize the oligosaccharide part of the GM1 ganglioside receptor. We report here the crystal structure of heat-labile enterotoxin in complex with the disaccharide portion of the Thomsen-Friedenreich (T-antigen) tumor marker. The toxin:carbohydrate complex is determined to 2.13 A resolution, yielding an R-factor of 18.5%. The T-antigen disaccharide, D-Gal-beta 1,3-GalNAc-Ser/Thr, is present in more than 85% of human carcinomas and monitoring its autoimmune response is used for the early detection of tumors. Insight into the molecular recognition of this tumor antigen by sugar binding proteins can benefit the development of a diagnostic tool for human carcinomas as well as a T-antigen directed anticancer drug delivery system.

About this Structure

1LTI is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli., van den Akker F, Steensma E, Hol WG, Protein Sci. 1996 Jun;5(6):1184-8. PMID:8762150

Page seeded by OCA on Thu Mar 20 12:35:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lti"
Personal tools