Glucocorticoid receptor
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *Glucocorticoid receptor DBD domain | |
| - | [[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> | + | **[[1gdc]], [[2gda]], [[1rgd]] – rGCR DBD – NMR – rat<br /> |
| - | [[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br /> | + | **[[3g9p]], [[3fyl]], [[3g6p]], [[3g6q]], [[3g6r]], [[3g6t]], [[3g6u]], [[3g8u]], [[3g8x]], [[3g97]], [[3g99]], [[3g9i]], [[3g9m]], [[3g9j]], [[3g9o]], [[1glu]], [[1lat]], [[1r4o]], [[1r4r]] - rGCR DBD + DNA<br /> |
| - | [[4hn5]], [[4hn6]] - hGCR DBD + DNA – human<br /> | + | **[[4hn5]], [[4hn6]] - hGCR DBD + DNA – human<br /> |
| - | + | *Glucocorticoid receptor LBD domain | |
| - | [[1m2z]], [[3cld]], [[3bqd]], [[4lsj]] - hGCR LBD (mutant) + NCOA2 peptide + steroid <br /> | + | **[[1m2z]], [[3cld]], [[3bqd]], [[4lsj]] - hGCR LBD (mutant) + NCOA2 peptide + steroid <br /> |
| - | [[3e7c]] - hGCR LBD (mutant) + NCOA2 peptide + non- | + | **[[3e7c]] - hGCR LBD (mutant) + NCOA2 peptide + non-steroidal agonist<br /> |
| - | [[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> | + | **[[3k23]] - hGCR LBD (mutant) + NCOA2 peptide + prolinamide<br /> |
| - | [[3k22]] - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide<br /> | + | **[[3k22]] - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide<br /> |
| - | [[3h52]] - hGCR LBD (mutant) + NCOA1 peptide + steroid<br /> | + | **[[3h52]] - hGCR LBD (mutant) + NCOA1 peptide + steroid<br /> |
| - | [[3gn8]] - hGCR LBD + NCOA2 peptide + steroid<br /> | + | **[[3gn8]] - hGCR LBD + NCOA2 peptide + steroid<br /> |
| - | [[3ry9]] - GCR LBD ancestral + steroid<br /> | + | **[[3ry9]] - GCR LBD ancestral + steroid<br /> |
| - | [[4e2j]] - GCR LBD ancestral + NCOA2 peptide + steroid<br /> | + | **[[4e2j]] - GCR LBD ancestral + NCOA2 peptide + steroid<br /> |
| - | [[3mne]], [[3mno]], [[3mnp]] - GCR LBD (mutant) + NCOA2 peptide + steroid<br /> – mouse | + | **[[3mne]], [[3mno]], [[3mnp]] - GCR LBD (mutant) + NCOA2 peptide + steroid<br /> – mouse |
| - | + | *Glucocorticoid receptor LBD+hinge domains | |
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| + | **[[1nhz]] – hGCR LBD+hinge (mutant) + steroid<br /> | ||
| + | **[[1p93]] - hGCR LBD+hinge (mutant) + NCOA2 peptide + steroid<br /> | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:38, 26 November 2014
Template:STRUCTURE 3g6r Glucocorticoid receptor (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression). GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD); hinge region; ligand-binding domain (LBD) and C terminal domain. GCR interacts with nuclear receptor coactivator 2 (NCOA2) which promotes DNA transcription by acylating histones.
3D structures of glucocorticoid receptor
Updated on 26-November-2014
