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4kpe

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'''Unreleased structure'''
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==Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate==
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<StructureSection load='4kpe' size='340' side='right' caption='[[4kpe]], [[Resolution|resolution]] 3.43&Aring;' scene=''>
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The entry 4kpe is ON HOLD until Nov 26 2015
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4kpe]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPE FirstGlance]. <br>
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Authors: Laponogov, I., Pan, X.-S., Vesekov, D.A., Cirz, R.T., Wagman, A.S., Moser, H.E., Fisher, L.M., Sanderson, M.R.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AF5:(7AR,8R)-8-AMINO-4-CYCLOPROPYL-12-FLUORO-1-OXO-4,7,7A,8,9,10-HEXAHYDRO-1H-PYRROLO[1,2 1,7]AZEPINO[2,3-H]QUINOLINE-2-CARBOXYLIC+ACID'>AF5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foe|3foe]], [[3fof|3fof]], [[2nov|2nov]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[4koe|4koe]], [[4kpf|4kpf]]</td></tr>
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Description: Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpe RCSB], [http://www.ebi.ac.uk/pdbsum/4kpe PDBsum]</span></td></tr>
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</table>
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__TOC__
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</StructureSection>
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[[Category: Cirz, R T]]
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[[Category: Fisher, L M]]
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[[Category: Laponogov, I]]
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[[Category: Moser, H E]]
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[[Category: Pan, X S]]
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[[Category: Sanderson, M R]]
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[[Category: Vesekov, D A]]
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[[Category: Wagman, A S]]
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[[Category: Achn-245]]
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[[Category: Isomerase-dna-inhibitor complex]]
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[[Category: Protein-dna cleavage complex]]
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[[Category: Quinolone]]
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[[Category: Topoisomerase iia]]

Revision as of 08:08, 26 November 2014

Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate

4kpe, resolution 3.43Å

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