3fbi
From Proteopedia
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| - | [[ | + | ==Structure of the Mediator submodule Med7N/31== |
| + | <StructureSection load='3fbi' size='340' side='right' caption='[[3fbi]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3fbi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FBI FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fbn|3fbn]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MED7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), MED31, SOH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fbi RCSB], [http://www.ebi.ac.uk/pdbsum/3fbi PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mediator is a modular multiprotein complex required for regulated transcription by RNA polymerase (Pol) II. Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31. In vitro, Med7N/31 is required for activated transcription and can act in trans when added exogenously. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport. Comparative phenotyping and transcriptome profiling identify specific and overlapping functions of different Mediator submodules. | ||
| - | + | Identification, structure, and functional requirement of the Mediator submodule Med7N/31.,Koschubs T, Seizl M, Lariviere L, Kurth F, Baumli S, Martin DE, Cramer P EMBO J. 2009 Jan 7;28(1):69-80. Epub 2008 Dec 4. PMID:19057509<ref>PMID:19057509</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
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==See Also== | ==See Also== | ||
*[[Mediator|Mediator]] | *[[Mediator|Mediator]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Baumli, S | + | [[Category: Baumli, S]] |
| - | [[Category: Cramer, P | + | [[Category: Cramer, P]] |
| - | [[Category: Koschubs, T | + | [[Category: Koschubs, T]] |
| - | [[Category: Kurth, F | + | [[Category: Kurth, F]] |
| - | [[Category: Lariviere, L | + | [[Category: Lariviere, L]] |
| - | [[Category: Martin, D E | + | [[Category: Martin, D E]] |
| - | [[Category: Seizl, M | + | [[Category: Seizl, M]] |
[[Category: Activator]] | [[Category: Activator]] | ||
[[Category: Nucleus]] | [[Category: Nucleus]] | ||
Revision as of 08:47, 26 November 2014
Structure of the Mediator submodule Med7N/31
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