Glyoxalase
From Proteopedia
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| - | + | *Glyoxalase 1 | |
| - | [[1bh5]] – hGLO (mutant) – human<br /> | + | **[[1bh5]] – hGLO (mutant) – human<br /> |
| - | [[1fa8]] – EcGLO – ''Escherichia coli''<br /> | + | **[[1fa8]] – EcGLO – ''Escherichia coli''<br /> |
| - | [[2c21]] – GLO – ''Leishmania major''<br /> | + | **[[2c21]] – GLO – ''Leishmania major''<br /> |
| - | [[1fro]] – hGLO + benzyl glutathione<br /> | + | **[[1fro]] – hGLO + benzyl glutathione<br /> |
| - | [[1qin]], [[1qip]] - hGLO + glutathione derivative<br /> | + | **[[1qin]], [[1qip]] - hGLO + glutathione derivative<br /> |
| - | [[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br /> | + | **[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br /> |
| - | [[2za0]] – GLO + methyl gerfelin – mouse<br /> | + | **[[2za0]] – GLO + methyl gerfelin – mouse<br /> |
| - | [[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum'' | + | **[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum'' |
| - | + | *Glyoxalase 2 | |
| - | [[1xm8]] – GLO – ''Arabidopsis thaliana''<br /> | + | **[[1xm8]] – GLO – ''Arabidopsis thaliana''<br /> |
| - | [[2p18]] - LiGLO – ''Leishmania infantum''<br /> | + | **[[2p18]] - LiGLO – ''Leishmania infantum''<br /> |
| - | [[1qh3]] – hGLO + actate + cacodylate<br /> | + | **[[1qh3]] – hGLO + actate + cacodylate<br /> |
| - | [[1qh5]] – hGLO + glutathione derivative<br /> | + | **[[1qh5]] – hGLO + glutathione derivative<br /> |
| - | [[2p1e]] – LiGLO + lactate | + | **[[2p1e]] – LiGLO + lactate |
| - | + | *Glyoxalase 3 | |
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| - | + | ||
| + | **[[4lru]] – GLO – ''Candida albicans''<br /> | ||
| + | }} | ||
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Revision as of 11:17, 26 November 2014
Glyoxalase (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism.
- GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.
- GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.
3D structures of glyoxalase
Updated on 26-November-2014
