1m4r

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[[Image:1m4r.jpg|left|200px]]<br /><applet load="1m4r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1m4r.jpg|left|200px]]
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caption="1m4r, resolution 2.00&Aring;" />
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''<br />
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{{Structure
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|PDB= 1m4r |SIZE=350|CAPTION= <scene name='initialview01'>1m4r</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1M4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4R OCA].
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1M4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4R OCA].
==Reference==
==Reference==
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Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12176383 12176383]
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Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12176383 12176383]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Renauld, J C.]]
[[Category: Renauld, J C.]]
[[Category: crystal structure]]
[[Category: crystal structure]]
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[[Category: cytokines]]
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[[Category: cytokine]]
[[Category: interferon-gamma]]
[[Category: interferon-gamma]]
[[Category: interleukin-10 (il-10)]]
[[Category: interleukin-10 (il-10)]]
[[Category: interleukin-22 (il-22)]]
[[Category: interleukin-22 (il-22)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:51:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:38:49 2008''

Revision as of 10:38, 20 March 2008

Image:1m4r.jpg


PDB ID 1m4r

Drag the structure with the mouse to rotate
, resolution 2.00Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22


Overview

Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.

About this Structure

1M4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:12176383

Page seeded by OCA on Thu Mar 20 12:38:49 2008

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