Gyrase

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{{STRUCTURE_3uc1| PDB=3uc1 | SIZE=400| SCENE= |right|CAPTION=Gyrase type IIA subunit A C-terminal domain with Ca+2 (green), acetate and glycerol, [[3uc1]] }}
{{STRUCTURE_3uc1| PDB=3uc1 | SIZE=400| SCENE= |right|CAPTION=Gyrase type IIA subunit A C-terminal domain with Ca+2 (green), acetate and glycerol, [[3uc1]] }}
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Gyrase Subunit A===
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*Gyrase Subunit A
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[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br />
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[[2wl2]], [[2y3p]], [[4ckl]] – EcGyrA N-terminal+simocylinone – ''Escherichia coli''<br />
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[[1ajb]] - EcGyrA N-terminal+novobiocin<br />
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[[4ckk]] - EcGyrA N-terminal<br />
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[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br />
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[[3ku8]] – EcGyrA fragment+CcdB<br />
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[[1x75]] – EcGyrA14+CcdB<br />
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[[3kua]], [[4elz]] - GyrA fragment+CcdB – ''Vibrio fischeri''<br />
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[[3ilw]], [[3ifz]] - MtGyrA ATPase domain – ''Mycobacterium tuberculosis''<br />
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[[3uc1]], [[4g3n]] - MtGyrA C-terminal<br />
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[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br />
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[[3no0]] - GyrA C-terminal – ''Aquifex aeolicus''<br />
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[[3lpx]] – GyrA N-terminal – ''Colwellia psychrerithraea''<br />
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[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br />
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[[4ddq]] – GyrA – ''Bacillus subtilis''<br />
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===Gyrase Subunit B===
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**[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br />
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**[[2wl2]], [[2y3p]], [[4ckl]] – EcGyrA N-terminal+simocylinone – ''Escherichia coli''<br />
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**[[1ajb]] - EcGyrA N-terminal+novobiocin<br />
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**[[4ckk]] - EcGyrA N-terminal<br />
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**[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br />
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**[[3ku8]] – EcGyrA fragment+CcdB<br />
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**[[1x75]] – EcGyrA14+CcdB<br />
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**[[3kua]], [[4elz]] - GyrA fragment+CcdB – ''Vibrio fischeri''<br />
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**[[3ilw]], [[3ifz]] - MtGyrA ATPase domain – ''Mycobacterium tuberculosis''<br />
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**[[3uc1]], [[4g3n]] - MtGyrA C-terminal<br />
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**[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br />
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**[[3no0]] - GyrA C-terminal – ''Aquifex aeolicus''<br />
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**[[3lpx]] – GyrA N-terminal – ''Colwellia psychrerithraea''<br />
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**[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br />
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**[[4ddq]] – GyrA – ''Bacillus subtilis''<br />
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[[3g75]], [[3g7b]], [[3g7e]] – GyrB+thiazole inhibitor – ''Staphylococcus aureus''<br />
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*Gyrase Subunit B
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[[3ttz]], [[3u2d]], [[3u2k]] – SaGyrB + pyrrolamide inhibitor<br />
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[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
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[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
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[[1kzn]], [[1ei1]] - EcGyrB N-terminal+clorobiocin<br />
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[[1aj6]] - EcGyrB N-terminal+novobiocin<br />
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[[4duh]] - EcGyrB N-terminal+ inhibitor<br />
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[[4hyp]] - EcGyrB + inhibitor<br />
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[[1kij]] – GyrB domain+novobiocin – ''Thermus thermophilus''<br />
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[[4b6c]] - GyrB ATPase domain – ''Mycobacterium smegmatis''<br />
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[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
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[[3zkb]], [[3zkd]] - MtGyrB ATPase domain + AMPPNP<br />
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[[3zm7]] - MtGyrB ATPase domain + AMPPCP<br />
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[[4bae]] - MtGyrB ATPase domain (mutant) + inhibitor<br />
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===Gyrase Subunit A+Subunit B===
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**[[3g75]], [[3g7b]], [[3g7e]] – GyrB+thiazole inhibitor – ''Staphylococcus aureus''<br />
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**[[3ttz]], [[3u2d]], [[3u2k]] – SaGyrB + pyrrolamide inhibitor<br />
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**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
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**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
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**[[1kzn]], [[1ei1]] - EcGyrB N-terminal+clorobiocin<br />
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**[[1aj6]] - EcGyrB N-terminal+novobiocin<br />
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**[[4duh]] - EcGyrB N-terminal+ inhibitor<br />
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**[[4hyp]] - EcGyrB + inhibitor<br />
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**[[1kij]] – GyrB domain+novobiocin – ''Thermus thermophilus''<br />
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**[[4b6c]] - GyrB ATPase domain – ''Mycobacterium smegmatis''<br />
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**[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
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**[[3zkb]], [[3zkd]] - MtGyrB ATPase domain + AMPPNP<br />
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**[[3zm7]] - MtGyrB ATPase domain + AMPPCP<br />
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**[[4bae]] - MtGyrB ATPase domain (mutant) + inhibitor<br />
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[[2xco]], [[2xcq]] - SaGyrB C-terminal-SaGyrA N-terminal fusion<br />
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*Gyrase Subunit A+Subunit B
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[[2xcr]], [[2xcs]], [[4bul]] - SaGyrB C-terminal-SaGyrA N-terminal fusion (mutant)+DNA<br />
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[[2xct]] - SaGyrB C-terminal-SaGyrA N-terminal fusion (mutant) +DNA+ ciprofloxacin<br />
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[[3nuh]] – EcGyrA+EcGyrB
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===Reverse Gyrase===
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**[[2xco]], [[2xcq]] - SaGyrB C-terminal-SaGyrA N-terminal fusion<br />
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**[[2xcr]], [[2xcs]], [[4bul]] - SaGyrB C-terminal-SaGyrA N-terminal fusion (mutant)+DNA<br />
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**[[2xct]] - SaGyrB C-terminal-SaGyrA N-terminal fusion (mutant) +DNA+ ciprofloxacin<br />
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**[[3nuh]] – EcGyrA+EcGyrB
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[[1gku]] – AfTop-RG – ''Archaeoglobus fulgidus''<br />
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*Reverse Gyrase
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[[1gl9]] - AfTop-RG+ADPNP<br />
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[[3oiy]], [[3p4y]] – TmTop-RG helicase domain – ''Thermotoga maritima''<br />
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[[4ddt]], [[4ddu]], [[4ddv]], [[4ddw]], [[4ddx]] - TmTop-RG
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**[[1gku]] – AfTop-RG – ''Archaeoglobus fulgidus''<br />
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**[[1gl9]] - AfTop-RG+ADPNP<br />
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**[[3oiy]], [[3p4y]] – TmTop-RG helicase domain – ''Thermotoga maritima''<br />
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**[[4ddt]], [[4ddu]], [[4ddv]], [[4ddw]], [[4ddx]] - TmTop-RG
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}}
==Additional Resources==
==Additional Resources==
For additional information, see: [[Bacterial Infections]]
For additional information, see: [[Bacterial Infections]]

Revision as of 07:16, 27 November 2014

Template:STRUCTURE 3uc1

Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil. [1]

3D Structure of Gyrase

Updated on 27-November-2014

Additional Resources

For additional information, see: Bacterial Infections

References

  1. ↑ Gore J, Bryant Z, Stone MD, Nollmann M, Cozzarelli NR, Bustamante C. Mechanochemical analysis of DNA gyrase using rotor bead tracking. Nature. 2006 Jan 5;439(7072):100-4. PMID:16397501 doi:10.1038/nature04319

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman

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