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Heat Shock Proteins

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Small Hsp===
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*Small Hsp
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[[1shs]], [[4eld]] – Hsp – ''Methanococcus jannaschii''<br />
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**[[1shs]], [[4eld]] – Hsp – ''Methanococcus jannaschii''<br />
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[[1gme]] – Hsp 17kD – wheat<br />
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**[[1gme]] – Hsp 17kD – wheat<br />
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[[2bol]] – Hsp – ''Taenia saginata''<br />
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**[[2bol]] – Hsp – ''Taenia saginata''<br />
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[[2h50]], [[2h53]] – yHsp26 – yeast<br />
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**[[2h50]], [[2h53]] – yHsp26 – yeast<br />
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[[2l9q]], [[2ljl]], [[4axp]] – yHsp12 - NMR<br />
+
**[[2l9q]], [[2ljl]], [[4axp]] – yHsp12 - NMR<br />
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[[2wj5]] – rHsp20 crystallin domain – rat<br />
+
**[[2wj5]] – rHsp20 crystallin domain – rat<br />
-
[[2wj7]], [[3l1g]] – hHspB crystallin domain – human<br />
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**[[2wj7]], [[3l1g]] – hHspB crystallin domain – human<br />
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[[3q9p]], [[3q9q]] – hHsp28 β1<br/>
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**[[3q9p]], [[3q9q]] – hHsp28 β1<br/>
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[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br />
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**[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br />
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[[1ons]] – EcHsp31<br />
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**[[1ons]] – EcHsp31<br />
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[[3gla]], [[3gt6]], [[3guf]] – Hsp – ''Xanthomonas axonopodis''<br />
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**[[3gla]], [[3gt6]], [[3guf]] – Hsp – ''Xanthomonas axonopodis''<br />
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[[3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
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**[[3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br />
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[[3vql]] – StHsp14 (mutant)<br />
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**[[3vql]] – StHsp14 (mutant)<br />
-
[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
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**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br />
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===Hsp33===
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*Hsp33
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[[1hw7]], [[3m7m]] – EcHsp33 N-terminal <br />
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**[[1hw7]], [[3m7m]] – EcHsp33 N-terminal <br />
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[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
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**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
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[[1xjh]] - EcHsp33 C-terminal - NMR<br />
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**[[1xjh]] - EcHsp33 C-terminal - NMR<br />
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[[1vq0]] – Hsp33 – ''Thermotoga maritima''<br />
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**[[1vq0]] – Hsp33 – ''Thermotoga maritima''<br />
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[[1vzy]] – Hsp33 – ''Bacillus subtilis''
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**[[1vzy]] – Hsp33 – ''Bacillus subtilis''
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===HslV, HslU, HslJ===
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*HslV, HslU, HslJ
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[[1e94]], [[1yyf]] – EcHslV+HslU <br />
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**[[1e94]], [[1yyf]] – EcHslV+HslU <br />
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[[2kts]] – EcHslJ - NMR<br />
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**[[2kts]] – EcHslJ - NMR<br />
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[[1g41]] – HiHslU – ''Haemophilus influenza''<br />
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**[[1g41]] – HiHslU – ''Haemophilus influenza''<br />
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[[1im2]] – HiHslU NBD
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**[[1im2]] – HiHslU NBD
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===Hsp40===
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*Hsp40
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[[1c3g]] – yHsp40 C-terminal peptide binding domain<br />
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**[[1c3g]] – yHsp40 C-terminal peptide binding domain<br />
-
[[2qld]] – hHsp40<br />
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**[[2qld]] – hHsp40<br />
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[[1hdj]] – hHsp40 J domain - NMR
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**[[1hdj]] – hHsp40 J domain - NMR
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=== Hsp60 - the large subunit of the chaperonin molecule GroEL ===
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* Hsp60 - the large subunit of the chaperonin molecule GroEL
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[[3los]] – MmHsp60 - GroEL – ''Methanococcus maripaludis'' – closed state<br />
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**[[3los]] – MmHsp60 - GroEL – ''Methanococcus maripaludis'' – closed state<br />
-
[[3iyf]] - MmHsp60 - GroEL – open state<br />
+
**[[3iyf]] - MmHsp60 - GroEL – open state<br />
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[[3e76]] – EcHsp60 – GroEL+Tl ion – ''Escherichia coli''<br />
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**[[3e76]] – EcHsp60 – GroEL+Tl ion – ''Escherichia coli''<br />
-
[[2nwc]], [[1oel]], [[1grl]], [[1la1]] - EcHsp60 – GroEL<br />
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**[[2nwc]], [[1oel]], [[1grl]], [[1la1]] - EcHsp60 – GroEL<br />
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[[2eu1]] - EcHsp60 (mutant) – GroEL<br />
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**[[2eu1]] - EcHsp60 (mutant) – GroEL<br />
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[[2cgt]] - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31<br />
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**[[2cgt]] - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31<br />
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[[2c7c]], [[2c7d]] - EcHsp60 – GroEL+GroES – cryo EM<br />
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**[[2c7c]], [[2c7d]] - EcHsp60 – GroEL+GroES – cryo EM<br />
-
[[1we3]], [[1wf4]] - TtHsp60 – GroEL+GroES – ''Thermus thermophilus''<br />
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**[[1we3]], [[1wf4]] - TtHsp60 – GroEL+GroES – ''Thermus thermophilus''<br />
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[[1gr5]] - EcHsp60 – GroEL – cryo EM<br />
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**[[1gr5]] - EcHsp60 – GroEL – cryo EM<br />
-
[[1gru]] - EcHsp60 – GroEL+ATP+GroES+ADP – cryo EM<br />
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**[[1gru]] - EcHsp60 – GroEL+ATP+GroES+ADP – cryo EM<br />
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[[1dkd]] - EcHsp60 – GroEL apical (top) domain (146 amino acids)+12-mer peptide<br />
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**[[1dkd]] - EcHsp60 – GroEL apical (top) domain (146 amino acids)+12-mer peptide<br />
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[[1dk7]], [[1jon]] - EcHsp60 – GroEL apical domain <br />
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**[[1dk7]], [[1jon]] - EcHsp60 – GroEL apical domain <br />
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[[1srv]] - TtHsp60 – GroEL apical domain<br />
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**[[1srv]] - TtHsp60 – GroEL apical domain<br />
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[[1ass]], [[1asx]] - Hsp60 – GroEL apical domain – ''Thermoplasma acidophilum''<br />
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**[[1ass]], [[1asx]] - Hsp60 – GroEL apical domain – ''Thermoplasma acidophilum''<br />
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[[1kid]] - EcHsp60 (mutant) – GroEL apical domain<br />
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**[[1kid]] - EcHsp60 (mutant) – GroEL apical domain<br />
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=== Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD); hydrophobic amino acid binding domain (sub): C-terminus lid domain (lid). ===
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* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD); hydrophobic amino acid binding domain (sub): C-terminus lid domain (lid).
-
[[3a8y]] – hHsp70 NBD+BAG domain regulator protein – human<br />
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**[[3a8y]] – hHsp70 NBD+BAG domain regulator protein – human<br />
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[[3fzf]] - hHsp70 NBD+BAG domain regulator protein+ATP<br />
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**[[3fzf]] - hHsp70 NBD+BAG domain regulator protein+ATP<br />
-
[[3fzh]], [[3fzm]], [[3ldq]], [[3m3z]] - hHsp70 NBD+BAG domain regulator protein+ adenosine derivative<br />
+
**[[3fzh]], [[3fzm]], [[3ldq]], [[3m3z]] - hHsp70 NBD+BAG domain regulator protein+ adenosine derivative<br />
-
[[3fzk]], [[3fzl]] - hHsp70 NBD+BAG domain regulator protein+ purine derivative<br />
+
**[[3fzk]], [[3fzl]] - hHsp70 NBD+BAG domain regulator protein+ purine derivative<br />
-
[[3cqx]] - Hsp70 NBD+BAG domain regulator protein – mouse<br />
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**[[3cqx]] - Hsp70 NBD+BAG domain regulator protein – mouse<br />
-
[[3lof]] – hHsp70 lid<br />
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**[[3lof]] – hHsp70 lid<br />
-
[[2lmg]] – hHsp70 C terminal - NMR<br />
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**[[2lmg]] – hHsp70 C terminal - NMR<br />
-
[[1xqs]] – hHsp70 sub + Hsp-binding protein core domain<br />
+
**[[1xqs]] – hHsp70 sub + Hsp-binding protein core domain<br />
-
[[2p32]] - CeHsp70 lid<br />
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**[[2p32]] - CeHsp70 lid<br />
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[[3l6q]] - CpHsp70 NBD – ''Cryptosporidium parvum''<br />
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**[[3l6q]] - CpHsp70 NBD – ''Cryptosporidium parvum''<br />
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[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
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**[[3kvg]] - CpHsp70 NBD+AMPPNP<br />
-
[[3l4i]] - CpHsp70 NBD+ADP+P<br />
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**[[3l4i]] - CpHsp70 NBD+ADP+P<br />
-
[[3jxu]], [[3i33]], [[3gdq]], [[3fe1]] - hHsp70 NBD+ADP+P<br />
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**[[3jxu]], [[3i33]], [[3gdq]], [[3fe1]] - hHsp70 NBD+ADP+P<br />
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[[3iuc]], [[3atu]], [[3atv]], [[3ay9]] - hHsp70 NBD+ADP<br />
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**[[3iuc]], [[3atu]], [[3atv]], [[3ay9]] - hHsp70 NBD+ADP<br />
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[[4j8f]] - hHsp70 NBD/HIP middle domain<br />
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**[[4j8f]] - hHsp70 NBD/HIP middle domain<br />
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[[2e88]], [[1s3x]], [[1hjo]] - hHsp70 NBD<br />
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**[[2e88]], [[1s3x]], [[1hjo]] - hHsp70 NBD<br />
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[[2e8a]] - hHsp70 NBD+AMPPNP<br />
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**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
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[[2qw9]] – bHsp70 NBD – bovine<br />
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**[[2qw9]] – bHsp70 NBD – bovine<br />
-
[[2bup]], [[1bup]], [[1qqm]], [[1qqn]] - bHsp70 NBD (mutant)<br />
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**[[2bup]], [[1bup]], [[1qqm]], [[1qqn]] - bHsp70 NBD (mutant)<br />
-
[[2qwl]], [[2qwm]], [[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[3hsc]] - bHsp70 NBD+ADP<br />
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**[[2qwl]], [[2qwm]], [[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[3hsc]] - bHsp70 NBD+ADP<br />
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[[1qqo]] – bHsp70 (mutant)<br />
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**[[1qqo]] – bHsp70 (mutant)<br />
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[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsp70 NBD (mutant)+ auxilin protein<br />
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**[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsp70 NBD (mutant)+ auxilin protein<br />
-
[[1ba0]], [[1ba1]] – bHsp70 NBD (mutant) + ADP<br />
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**[[1ba0]], [[1ba1]] – bHsp70 NBD (mutant) + ADP<br />
-
[[1kax]], [[1kay]], [[1kaz]] - bHsp70 NBD (mutant) + ATP<br />
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**[[1kax]], [[1kay]], [[1kaz]] - bHsp70 NBD (mutant) + ATP<br />
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[[1nge]], [[1ngf]], [[1ngg]], [[1ngh]] - bHsp70 NBD + ATP<br />
+
**[[1nge]], [[1ngf]], [[1ngg]], [[1ngh]] - bHsp70 NBD + ATP<br />
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[[1ngi]], [[1ngj]] - bHsp70 NBD + phosphoaminophosphonic acid<br />
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**[[1ngi]], [[1ngj]] - bHsp70 NBD + phosphoaminophosphonic acid<br />
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[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
+
**[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
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[[2kho]] – EcHsp70 – ''Escherichia coli'' – NMR<br />
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**[[2kho]] – EcHsp70 – ''Escherichia coli'' – NMR<br />
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[[1q5l]] - EcHsp70 sub domain+peptide - NMR<br />
+
**[[1q5l]] - EcHsp70 sub domain+peptide - NMR<br />
-
[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
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**[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
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[[3dpo]] – EcHsp70 sub+12-mer peptide<br />
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**[[3dpo]] – EcHsp70 sub+12-mer peptide<br />
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[[3dpp]], [[3dpq]] – EcHsp70 sub+20-mer peptide<br />
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**[[3dpp]], [[3dpq]] – EcHsp70 sub+20-mer peptide<br />
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[[3dob]], [[3dqg]], [[2op6]] - CeHsp70 sub – ''Caenoharbditis elegans''<br />
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**[[3dob]], [[3dqg]], [[2op6]] - CeHsp70 sub – ''Caenoharbditis elegans''<br />
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[[4i2w]] – CeHsp70 + myosin chaperone<br />
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**[[4i2w]] – CeHsp70 + myosin chaperone<br />
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[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
+
**[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
-
[[2v7z]] – rHsp70 NBD+sub – rat<br />
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**[[2v7z]] – rHsp70 NBD+sub – rat<br />
-
[[7hsc]], [[1ckr]] - rHsp70 sub - NMR<br />
+
**[[7hsc]], [[1ckr]] - rHsp70 sub - NMR<br />
-
[[3lca]] – yHsp70 Ssa1 C-terminal+yTOM71<br />
+
**[[3lca]] – yHsp70 Ssa1 C-terminal+yTOM71<br />
-
[[2v7y]] – Hsp70 NBD+sub – ''Geobacillus kaustophilus''
+
**[[2v7y]] – Hsp70 NBD+sub – ''Geobacillus kaustophilus''
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===Hsp83===
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*Hsp83
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[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''
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**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major''
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=== Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT) ===
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* Hsp90 – 4 domains: N-terminus (NTD); linker; middle (MD); C-terminus (CT)
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''Hsp90 NTD''
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*''Hsp90 NTD''
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[[3t0h]] - hHsp90-α NTD – human<br />
+
**[[3t0h]] - hHsp90-α NTD – human<br />
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[[3t0z]], [[3t2s]] - hHsp90-α NTD + ATP derivative<br />
+
**[[3t0z]], [[3t2s]] - hHsp90-α NTD + ATP derivative<br />
-
[[3t10]] - hHsp90-α NTD + ACP<br />
+
**[[3t10]] - hHsp90-α NTD + ACP<br />
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[[3t1k]] - hHsp90-α NTD + ANP<br />
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**[[3t1k]] - hHsp90-α NTD + ANP<br />
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[[3k97]], [[3hek]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative – human<br />
+
**[[3k97]], [[3hek]], [[3mnq]] – hHsp90 NTD+pyrrolidin derivative – human<br />
-
[[3k98]], [[3k99]], [[3qtf]] - hHsp90 NTD+indole derivative<br />
+
**[[3k98]], [[3k99]], [[3qtf]] - hHsp90 NTD+indole derivative<br />
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[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
+
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
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[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
+
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
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[[3ft8]], [[3ft5]] - hHsp90 NTD+quinazoline derivative<br />
+
**[[3ft8]], [[3ft5]] - hHsp90 NTD+quinazoline derivative<br />
-
[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
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**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
-
[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
+
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
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[[3bm9]], [[3bmy]] - hHsp90 NTD+benzisoxazole<br />
+
**[[3bm9]], [[3bmy]] - hHsp90 NTD+benzisoxazole<br />
-
[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
+
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br />
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[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]] - hHsp90 NTD+pyrimidine derivative<br />
+
**[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]] - hHsp90 NTD+pyrimidine derivative<br />
-
[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]] - hHsp90 NTD+purine derivative<br />
+
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]] - hHsp90 NTD+purine derivative<br />
-
[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative<br />
+
**[[2qg0]], [[2bz5]] - hHsp90 NTD+sulfonamide derivative<br />
-
[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]] - hHsp90 NTD + thiadiazole derivative<br />
+
**[[2yi0]], [[2yi5]], [[2yi6]], [[2yi7]] - hHsp90 NTD + thiadiazole derivative<br />
-
[[4hy6]] - hHsp90 NTD + indazole derivative<br />
+
**[[4hy6]] - hHsp90 NTD + indazole derivative<br />
-
[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
+
**[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
-
[[3d0b]], [[3rkz]] - hHsp90 NTD+benzamide derivative<br />
+
**[[3d0b]], [[3rkz]] - hHsp90 NTD+benzamide derivative<br />
-
[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
+
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
-
[[2fwy]], [[2fwz]], [[2h55]], [[1uym]], [[3o0l]] - hHsp90 NTD+PU inhibitor<br />
+
**[[2fwy]], [[2fwz]], [[2h55]], [[1uym]], [[3o0l]] - hHsp90 NTD+PU inhibitor<br />
-
[[2ccs]], [[2cct]], [[2ccu]], [[2cdd]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]] - hHsp90 NTD+pyrazol derivative<br />
+
**[[2ccs]], [[2cct]], [[2ccu]], [[2cdd]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]] - hHsp90 NTD+pyrazol derivative<br />
-
[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]]- hHsp90 NTD + inhibitor<br />
+
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]]- hHsp90 NTD + inhibitor<br />
-
[[1byq]] - hHsp90 NTD+ATP-Mg<br />
+
**[[1byq]] - hHsp90 NTD+ATP-Mg<br />
-
[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]] - hHsp90 NTD+ antigen<br />
+
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]] - hHsp90 NTD+ antigen<br />
-
[[2brc]], [[2bre]], [[1am1]] - yHsp90 NTD+pyrazol derivative<br />
+
**[[2brc]], [[2bre]], [[1am1]] - yHsp90 NTD+pyrazol derivative<br />
-
[[1amw]] - yHsp90 NTD+ADP<br />
+
**[[1amw]] - yHsp90 NTD+ADP<br />
-
[[1ah6]], [[1ah8]] - yHsp90 NTD<br />
+
**[[1ah6]], [[1ah8]] - yHsp90 NTD<br />
-
[[1osf]], [[1yer]], [[1yes]], [[1yet]] - hHsp90 NTD+geldamycin <br />
+
**[[1osf]], [[1yer]], [[1yes]], [[1yet]] - hHsp90 NTD+geldamycin <br />
-
[[3ied]] - PfHsp90 NTD+AMPPN – ''Plasmodium falciparum''<br />
+
**[[3ied]] - PfHsp90 NTD+AMPPN – ''Plasmodium falciparum''<br />
-
[[3k60]] - PfHsp90 NTD+ADP<br />
+
**[[3k60]] - PfHsp90 NTD+ADP<br />
-
[[2jki]] - Hsp90 NTD+SGT1 domain protein – barley<br />
+
**[[2jki]] - Hsp90 NTD+SGT1 domain protein – barley<br />
-
[[2h8m]], [[2hch]] – dHsp90 NTD – dog<br />
+
**[[2h8m]], [[2hch]] – dHsp90 NTD – dog<br />
-
[[2hg1]] - dHsp90 NTD+ligand<br />
+
**[[2hg1]] - dHsp90 NTD+ligand<br />
-
[[2xcm]] – Hsp90 NTD+CGT1+RAR1 – ''Hordum vulgare''<br />
+
**[[2xcm]] – Hsp90 NTD+CGT1+RAR1 – ''Hordum vulgare''<br />
-
[[3h80]] – LmHsp90 NTD <br />
+
**[[3h80]] – LmHsp90 NTD <br />
-
[[3q5j]], [[3q5k]], [[3q5l]] - LmHsp90 NTD + inhibitor<br />
+
**[[3q5j]], [[3q5k]], [[3q5l]] - LmHsp90 NTD + inhibitor<br />
-
[[3o6o]], [[3omu]], [[3opd]] – TbHsp90 NTD+inhibitor – ''Trypanosoma brucei''<br />
+
**[[3o6o]], [[3omu]], [[3opd]] – TbHsp90 NTD+inhibitor – ''Trypanosoma brucei''<br />
-
[[4gqt]] – CeHsp90 NTD
+
**[[4gqt]] – CeHsp90 NTD
-
''Hsp90 MD''
+
*''Hsp90 MD''
-
[[3pry]] – hHsp90 MD<br />
+
**[[3pry]] – hHsp90 MD<br />
-
[[2gq0]] - EcHsp90 MD<br />
+
**[[2gq0]] - EcHsp90 MD<br />
-
''Hsp90 CT''
+
*''Hsp90 CT''
-
[[1sf8]] – EcHsp90 CT<br />
+
**[[1sf8]] – EcHsp90 CT<br />
-
[[3hjc]] - LmHsp90 CT<br />
+
**[[3hjc]] - LmHsp90 CT<br />
-
''Hsp90 NTD + MD''
+
*''Hsp90 NTD + MD''
-
[[2o1w]] - dHsp90 NTD+MD<br />
+
**[[2o1w]] - dHsp90 NTD+MD<br />
-
''Hsp90 MD + CT''
+
*''Hsp90 MD + CT''
-
[[3q6m]], [[3q6n]] - hHsp90 MD + CT<br />
+
**[[3q6m]], [[3q6n]] - hHsp90 MD + CT<br />
-
[[2o1t]] – dHsp90 MD+CT<br />
+
**[[2o1t]] – dHsp90 MD+CT<br />
-
[[1bgq]] – yHsp90+radicicol<br />
+
*Hsp90
-
[[1a4h]], [[2weq]] – yHsp90+ geldamycin<br />
+
-
[[1y4s]], [[1y4u]], [[2iop]], [[2ior]] - EcHsp90+ADP<br />
+
-
[[2ioq]] - EcHsp90 <br />
+
-
[[2o1u]] – dHsp90+AMPPNP<br />
+
-
[[2o1v]] - dHsp90+ADP<br />
+
-
[[2qf6]] - hHsp90 + antigen<br />
+
-
=== Hsp82 is the yeast equivalent of Hsp90 in mammals ===
+
**[[1bgq]] – yHsp90+radicicol<br />
 +
**[[1a4h]], [[2weq]] – yHsp90+ geldamycin<br />
 +
**[[1y4s]], [[1y4u]], [[2iop]], [[2ior]] - EcHsp90+ADP<br />
 +
**[[2ioq]] - EcHsp90 <br />
 +
**[[2o1u]] – dHsp90+AMPPNP<br />
 +
**[[2o1v]] - dHsp90+ADP<br />
 +
**[[2qf6]] - hHsp90 + antigen<br />
-
[[1ah6]], [[1ah8]] – yHsp82 NTD1ah6, 1ah8 – yHsp82 NTD<br />
+
* Hsp82 is the yeast equivalent of Hsp90 in mammals
-
[[2xd6]] - yHsp82 NTD+macrolactone<br />
+
-
[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
+
-
[[2akp]] - yHsp82 NTD (mutant)<br />
+
-
[[1weq]], [[3c11]] - yHsp82 NTD (mutant)+ geldamycin<br />
+
-
[[2wer]] - yHsp82 NTD (mutant)+radicicol<br />
+
-
[[1bgq]] - yHsp82 NTD +radicicol<br />
+
-
[[2iws]], [[2iwu]], [[2iwx]], [[2cgf]] - yHsp82 NTD +radicicol analogues<br />
+
-
[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
+
-
[[3c0e]] - yHsp82 NTD (mutant)<br />
+
-
[[2fxs]] - yHsp82 NTD +radamide<br />
+
-
[[1zw9]] - yHsp82 NTD + adenine derivative<br />
+
-
[[1zwh]] - yHsp82 NTD + radester amine<br />
+
-
[[2brc]], [[2bre]] - yHsp82 NTD+pyrazol derivative<br />
+
-
[[2cg9]] – yHsp82+co-chaperone SBA1<br />
+
-
[[2cge]] - yHsp82 MD+CT+co-chaperone SBA1<br />
+
-
[[1hk7]] - yHsp82 MD<br />
+
-
[[1usu]], [[1usv]] - yHsp82 MD+co-chaperone AHA1<br />
+
-
[[1us7]] - yHsp82 NTD+co-chaperone cdc37<br />
+
-
[[3fp2]] – yHsp82 CT+TOM71
+
-
=== Hsp100 are named ClpA or ClpB ===
+
**[[1ah6]], [[1ah8]] – yHsp82 NTD1ah6, 1ah8 – yHsp82 NTD<br />
 +
**[[2xd6]] - yHsp82 NTD+macrolactone<br />
 +
**[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
 +
**[[2akp]] - yHsp82 NTD (mutant)<br />
 +
**[[1weq]], [[3c11]] - yHsp82 NTD (mutant)+ geldamycin<br />
 +
**[[2wer]] - yHsp82 NTD (mutant)+radicicol<br />
 +
**[[1bgq]] - yHsp82 NTD +radicicol<br />
 +
**[[2iws]], [[2iwu]], [[2iwx]], [[2cgf]] - yHsp82 NTD +radicicol analogues<br />
 +
**[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
 +
**[[3c0e]] - yHsp82 NTD (mutant)<br />
 +
**[[2fxs]] - yHsp82 NTD +radamide<br />
 +
**[[1zw9]] - yHsp82 NTD + adenine derivative<br />
 +
**[[1zwh]] - yHsp82 NTD + radester amine<br />
 +
**[[2brc]], [[2bre]] - yHsp82 NTD+pyrazol derivative<br />
 +
**[[2cg9]] – yHsp82+co-chaperone SBA1<br />
 +
**[[2cge]] - yHsp82 MD+CT+co-chaperone SBA1<br />
 +
**[[1hk7]] - yHsp82 MD<br />
 +
**[[1usu]], [[1usv]] - yHsp82 MD+co-chaperone AHA1<br />
 +
**[[1us7]] - yHsp82 NTD+co-chaperone cdc37<br />
 +
**[[3fp2]] – yHsp82 CT+TOM71
-
[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
+
* Hsp100 are named ClpA or ClpB
-
[[1khy]] – EcClpB NTD <br />
+
-
[[1jbk]] – EcClpB NBD<br />
+
-
[[1k6k]] - EcClpA NTD
+
 +
**[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
 +
**[[1khy]] – EcClpB NTD <br />
 +
**[[1jbk]] – EcClpB NBD<br />
 +
**[[1k6k]] - EcClpA NTD
-
=== Hsp110 in mammals is named Sse1, Sse2 in yeast ===
+
* Hsp110 in mammals is named Sse1, Sse2 in yeast
-
 
+
-
[[3d2e]], [[3d2f]], [[3c7n]] – ySse1+Hsp70 <br />
+
-
[[2qxl]] – ySse1<br />
+
-
[[2llv]] – ySti1 domain 1 – NMR<br />
+
-
[[2llw]] – ySti1 domain 2 – NMR<br />
+
-
[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
+
-
[[3uq3]] - ySti1 TPR repeats 4-9 + peptide
+
 +
**[[3d2e]], [[3d2f]], [[3c7n]] – ySse1+Hsp70 <br />
 +
**[[2qxl]] – ySse1<br />
 +
**[[2llv]] – ySti1 domain 1 – NMR<br />
 +
**[[2llw]] – ySti1 domain 2 – NMR<br />
 +
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
 +
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:42, 27 November 2014

Template:STRUCTURE 3los

Heat Shock Proteins (Hsp). The Hsp are proteins which are expressed when cells are exposed to stresses like heat. Hsp60, Hsp70, Hsp90 etc. are named according to their molecular weights. Their function is to provide protection from stress. The image at the right corresponds to one representative Hsp, i.e. the crystal structure of Hsp60 from Methanococcus maripaludis (3los).

3D Structures of Heat Shock Proteins

Updated on 27-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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