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Importin

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== Structural highlights ==
== Structural highlights ==
 +
</StructureSection>
==3D structures of importin==
==3D structures of importin==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
'''IPO-α'''
+
*IPO-α
-
[[1ial]] – mIPO residues 44-496 – mouse<br />
+
**[[1ial]] – mIPO residues 44-496 – mouse<br />
-
[[1bk5]] – yIPO NLS-binding domain - yeast<br />
+
**[[1bk5]] – yIPO NLS-binding domain - yeast<br />
-
''IPO-α complex with NLS peptide''
+
*''IPO-α complex with NLS peptide''
-
[[1ejl]] – mIPO NLS-binding domain + SV40 large T antigen<br />
+
**[[1ejl]] – mIPO NLS-binding domain + SV40 large T antigen<br />
-
[[1ejy]] – mIPO NLS-binding domain + nucleoplasmin <br />
+
**[[1ejy]] – mIPO NLS-binding domain + nucleoplasmin <br />
-
[[2ynr]] – mIPO NLS-binding domain + B54NLS <br />
+
**[[2ynr]] – mIPO NLS-binding domain + B54NLS <br />
-
[[1bk6]] – yIPO NLS-binding domain + SV40 large T antigen<br />
+
**[[1bk6]] – yIPO NLS-binding domain + SV40 large T antigen<br />
-
[[1ee4]] – yIPO NLS-binding domain (mutant) + c-Myc<br />
+
**[[1ee4]] – yIPO NLS-binding domain (mutant) + c-Myc<br />
-
[[1ee5]] – yIPO NLS-binding domain (mutant) + nucleoplasmin<br />
+
**[[1ee5]] – yIPO NLS-binding domain (mutant) + nucleoplasmin<br />
-
[[1un0]], [[2c1t]] – yIPO NLS-binding domain (mutant) + Nup2<br />
+
**[[1un0]], [[2c1t]] – yIPO NLS-binding domain (mutant) + Nup2<br />
-
''IPO-α complex with protein''
+
*''IPO-α complex with protein''
-
[[1wa5]] – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter<br />
+
**[[1wa5]] – yIPO NLS-binding domain + GTPase Ran + IPO-α re-exporter<br />
-
'''IPO-α 1'''
+
*''IPO-α 1 complex with NLS peptide''
-
''IPO-α 1 complex with NLS peptide''
+
**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain + dUTPase<br />
 +
**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
-
[[4mz5]], [[4mz6]] – mIPO NLS-binding domain + dUTPase<br />
+
*''IPO-α 1 complex with protein''
-
[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
+
-
''IPO-α 1 complex with protein''
+
**[[2jdq]] – hIPO NLS-binding domain + polymerase basic protein 2 C terminal<br />
 +
**[[3tj3]] – hIPO NLS-binding domain + Nup50 N terminal<br />
 +
**[[2jdq]] – hIPO NLS-binding domain + telomerase reverse transcriptase peptide<br />
-
[[2jdq]] – hIPO NLS-binding domain + polymerase basic protein 2 C terminal<br />
+
*IPO-α 2
-
[[3tj3]] – hIPO NLS-binding domain + Nup50 N terminal<br />
+
-
[[2jdq]] – hIPO NLS-binding domain + telomerase reverse transcriptase peptide<br />
+
-
'''IPO-α 2'''
+
**[[3tpo]] – mIPO<br />
 +
**[[1iq1]] – mIPO NLS-binding + autoinhibitory peptide domains<br />
 +
**[[4e4v]] – hIPO NLS-binding domain (mutant) - human <br />
-
[[3tpo]] – mIPO<br />
+
*''IPO-α 2 complex with NLS peptide''
-
[[1iq1]] – mIPO NLS-binding + autoinhibitory peptide domains<br />
+
-
[[4e4v]] – hIPO NLS-binding domain (mutant) - human <br />
+
-
''IPO-α 2 complex with NLS peptide''
+
**[[1pjm]] – mIPO NLS-binding domain + retinoblastoma-associated protein<br />
 +
**[[1pjn]] – mIPO NLS-binding domain + histone-binding protein N1/N2<br />
 +
**[[1q1s]], [[1q1t]] – mIPO NLS-binding domain + SV40 large T antigen<br />
 +
**[[1y2a]], [[3q5u]] – mIPO NLS-binding domain + phospholipid scramblase <br />
 +
**[[2c1m]] – mIPO NLS-binding domain + Nup50<br />
 +
**[[3btr]] – mIPO NLS-binding domain + androgen receptor<br />
 +
**[[3knd]] – mIPO NLS-binding domain + targeting protein for KXLP2<br />
 +
**[[3l3q]] – mIPO NLS-binding domain + library peptide<br />
 +
**[[3oqs]] – mIPO NLS-binding domain + CLIC4<br />
 +
**[[3rz9]] – mIPO NLS-binding domain + KU80<br />
 +
**[[3rzx]] – mIPO NLS-binding domain + KU70<br />
 +
**[[3tpm]] – mIPO NLS-binding domain + MAL<br />
 +
**[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />
 +
**[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />
 +
**[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />
 +
**[[3uky]], [[3ukz]], [[3ul0]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />
 +
**[[3ul1]] – mIPO NLS-binding domain + nucleoplasmin <br />
 +
**[[4htv]] – mIPO NLS-binding domain + capsid protein <br />
 +
**[[4ba3]] – mIPO NLS-binding domain + A89NLS <br />
 +
**[[3zio]], [[3zip]], [[3ziq]], [[3zir]] – mIPO NLS-binding domain + minor site-specific NLS <br />
 +
**[[3zin]] – mIPO NLS-binding domain + nucleolar RNA helicase<br />
-
[[1pjm]] – mIPO NLS-binding domain + retinoblastoma-associated protein<br />
+
*''IPO-α 2 complex with protein''
-
[[1pjn]] – mIPO NLS-binding domain + histone-binding protein N1/N2<br />
+
-
[[1q1s]], [[1q1t]] – mIPO NLS-binding domain + SV40 large T antigen<br />
+
-
[[1y2a]], [[3q5u]] – mIPO NLS-binding domain + phospholipid scramblase <br />
+
-
[[2c1m]] – mIPO NLS-binding domain + Nup50<br />
+
-
[[3btr]] – mIPO NLS-binding domain + androgen receptor<br />
+
-
[[3knd]] – mIPO NLS-binding domain + targeting protein for KXLP2<br />
+
-
[[3l3q]] – mIPO NLS-binding domain + library peptide<br />
+
-
[[3oqs]] – mIPO NLS-binding domain + CLIC4<br />
+
-
[[3rz9]] – mIPO NLS-binding domain + KU80<br />
+
-
[[3rzx]] – mIPO NLS-binding domain + KU70<br />
+
-
[[3tpm]] – mIPO NLS-binding domain + MAL<br />
+
-
[[3ve6]] – mIPO NLS-binding domain + Venezuelan equine encephalitis virus<br />
+
-
[[3uvu]] – mIPO NLS-binding domain + flap endonuclease<br />
+
-
[[3ukw]], [[3ukx]] – mIPO NLS-binding domain + BIMAX<br />
+
-
[[3uky]], [[3ukz]], [[3ul0]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />
+
-
[[3ul1]] – mIPO NLS-binding domain + nucleoplasmin <br />
+
-
[[4htv]] – mIPO NLS-binding domain + capsid protein <br />
+
-
[[4ba3]] – mIPO NLS-binding domain + A89NLS <br />
+
-
[[3zio]], [[3zip]], [[3ziq]], [[3zir]] – mIPO NLS-binding domain + minor site-specific NLS <br />
+
-
[[3zin]] – mIPO NLS-binding domain + nucleolar RNA helicase<br />
+
-
''IPO-α 2 complex with protein''
+
**[[3fex]], [[3fey]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />
-
[[3fex]], [[3fey]] – mIPO NLS-binding domain + nuclear CAP-binding protein<br />
+
*IPO-β 1
-
'''IPO-β 1'''
+
**[[3nd2]] – yIPO <br />
 +
**[[1gcj]] – mIPO N terminal<br />
-
[[3nd2]] – yIPO <br />
+
*''IPO-β 1 complex with protein''
-
[[1gcj]] – mIPO N terminal<br />
+
-
''IPO-β 1 complex with protein''
+
**[[1qgx]], [[1qgr]] – hIPO + IPO-α 2 IBB domain<br />
 +
**[[1ibr]] – hIPO + GTPase Ran<br />
 +
**[[2bku]], [[3ea5]] – yIPO + GTPase Ran<br />
 +
**[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />
 +
**[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />
 +
**[[2p8q]], [[2q5d]], [[2qna]], [[3lww]] – hIPO + RNA U transporter N terminal<br />
 +
**[[1qgr]], [[3w5k]] – hIPO + zinc finger protein SNAI1<br />
 +
**[[2bpt]] – yIPO + Nup1<br />
 +
**[[1ukl]] – mIPO + SREBP-2<br />
-
[[1qgx]], [[1qgr]] – hIPO + IPO-α 2 IBB domain<br />
+
*IPO-β 2 (Transportin 1)
-
[[1ibr]] – hIPO + GTPase Ran<br />
+
-
[[2bku]], [[3ea5]] – yIPO + GTPase Ran<br />
+
-
[[1f59]], [[1o6p]], [[1o6o]] – hIPO + FXFG nucleoporin repeats<br />
+
-
[[1m5n]] – hIPO HEAT repeats 1-11 + parathyroid hormone-related protein NLS peptide<br />
+
-
[[2p8q]], [[2q5d]], [[2qna]], [[3lww]] – hIPO + RNA U transporter N terminal<br />
+
-
[[1qgr]], [[3w5k]] – hIPO + zinc finger protein SNAI1<br />
+
-
[[2bpt]] – yIPO + Nup1<br />
+
-
[[1ukl]] – mIPO + SREBP-2<br />
+
-
'''IPO-β 2 (Transportin 1)'''
+
**[[2z5j]], [[2qmr]] – hIPO <br />
-
[[2z5j]], [[2qmr]] – hIPO <br />
+
*''IPO-β 2 complex with protein''
-
''IPO-β 2 complex with protein''
+
**[[2h4m]], [[2ot8]], [[2z5n]] – hIPO + hnRNP peptide<br />
 +
**[[2z5k]], [[2z5m]] – hIPO + nuclear RNA export factor peptide<br />
 +
**[[2z5o]] – hIPO + JKTBP peptide<br />
 +
**[[4fdd]], [[4jlq]], [[4oo6]] – hIPO + RNA binding protein peptide<br />
 +
**[[4fq3]] – hIPO + FUS peptide<br />
-
[[2h4m]], [[2ot8]], [[2z5n]] – hIPO + hnRNP peptide<br />
+
*IPO-13
-
[[2z5k]], [[2z5m]] – hIPO + nuclear RNA export factor peptide<br />
+
-
[[2z5o]] – hIPO + JKTBP peptide<br />
+
-
[[4fdd]], [[4jlq]], [[4oo6]] – hIPO + RNA binding protein peptide<br />
+
-
[[4fq3]] – hIPO + FUS peptide<br />
+
-
 
+
-
'''IPO-13'''
+
-
 
+
-
[[2x19]] – hIPO + GTPase Ran<br />
+
-
[[2xwu]] – hIPO + UBC9<br />
+
-
[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />
+
 +
**[[2x19]] – hIPO + GTPase Ran<br />
 +
**[[2xwu]] – hIPO + UBC9<br />
 +
**[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />
 +
}}
== References ==
== References ==

Revision as of 10:39, 27 November 2014

Structure of yeast importin α NLS-binding domain (grey) complex with nucleoplasmin peptide (green) (PDB code 1ee5).

Drag the structure with the mouse to rotate

3D structures of importin

Updated on 27-November-2014

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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