Inorganic pyrophosphatase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Pyrophosphatase===
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*Pyrophosphatase
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[[1pyp]] – yPPase – yeast<br />
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**[[1pyp]] – yPPase – yeast<br />
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[[1igp]], [[1faj]], [[2eip]], [[1jfd]] – EcPPase – ''Escherichia coli''<br />
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**[[1igp]], [[1faj]], [[2eip]], [[1jfd]] – EcPPase – ''Escherichia coli''<br />
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[[1mjw]], [[1mjx]], [[1mjy]], [[1mjz]] - EcPPase (mutant)<br />
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**[[1mjw]], [[1mjx]], [[1mjy]], [[1mjz]] - EcPPase (mutant)<br />
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[[1b78]] - MjPPase – ''Methanocaldococcus jannaschii''<br />
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**[[1b78]] - MjPPase – ''Methanocaldococcus jannaschii''<br />
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[[1ude]] – PPase – ''Pyrococcus horikoshii''<br />
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**[[1ude]] – PPase – ''Pyrococcus horikoshii''<br />
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[[1twl]] – PPase – ''Pyrococcus furiosus''<br />
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**[[1twl]] – PPase – ''Pyrococcus furiosus''<br />
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[[1wpm]] - BsPPase – ''Bacillus subtilis''<br />
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**[[1wpm]] - BsPPase – ''Bacillus subtilis''<br />
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[[1sxv]] - MtPPase – ''Mycobacterium tuberculosis''<br />
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**[[1sxv]] - MtPPase – ''Mycobacterium tuberculosis''<br />
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[[4ecp]] - PPase – ''Mycobacterium leprae''<br />
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**[[4ecp]] - PPase – ''Mycobacterium leprae''<br />
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[[1ygz]], [[2bqx]] - HpPPase - ''Helicobacter pylori''<br />
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**[[1ygz]], [[2bqx]] - HpPPase - ''Helicobacter pylori''<br />
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[[3d53]], [[3emj]] - PPase – ''Rickettsia prowazekii''<br />
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**[[3d53]], [[3emj]] - PPase – ''Rickettsia prowazekii''<br />
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[[3d63]], [[3eiz]] - BpPPase – ''Burkholderia pseudomallei''<br />
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**[[3d63]], [[3eiz]] - BpPPase – ''Burkholderia pseudomallei''<br />
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[[3lo0]] - PPase – ''Ehrlichia chafeensis''<br />
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**[[3lo0]] - PPase – ''Ehrlichia chafeensis''<br />
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[[3qu5]], [[3qub]], [[3quc]] - BtPPase (mutant) – ''Bacterioides thetaiotaomicron''<br />
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**[[3qu5]], [[3qub]], [[3quc]] - BtPPase (mutant) – ''Bacterioides thetaiotaomicron''<br />
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[[3sw5]] – PPase – ''Bartonella henselae''<br />
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**[[3sw5]] – PPase – ''Bartonella henselae''<br />
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[[2prd]] – PPase – ''Thermus thermophilus''<br />
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**[[2prd]] – PPase – ''Thermus thermophilus''<br />
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[[3r6e]] – TtPPase – ''Thermococcus thioreducens''<br />
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**[[3r6e]] – TtPPase – ''Thermococcus thioreducens''<br />
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''Pyrophosphatase binary complex''
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*Pyrophosphatase binary complex
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[[1ino]] – EcPPase + Mn<br />
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**[[1ino]] – EcPPase + Mn<br />
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[[1ipw]], [[1obw]] - EcPPase + Mg<br />
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**[[1ipw]], [[1obw]] - EcPPase + Mg<br />
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[[1i40]] - EcPPase + Ca<br />
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**[[1i40]] - EcPPase + Ca<br />
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[[1wgi]] - yPPase + Mn<br />
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**[[1wgi]] - yPPase + Mn<br />
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[[1huk]] - yPPase + Mg<br />
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**[[1huk]] - yPPase + Mg<br />
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[[1huj]], [[2ik1]] - yPPase (mutant) + Mg<br />
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**[[1huj]], [[2ik1]] - yPPase (mutant) + Mg<br />
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[[1qez]] - PPase + Mg – ''Sulfolobus acidocaldarius''<br />
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**[[1qez]] - PPase + Mg – ''Sulfolobus acidocaldarius''<br />
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[[3r5u]] – TtPPase + Mn <br />
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**[[3r5u]] – TtPPase + Mn <br />
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[[3r5v]] – TtPPase + Ca<br />
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**[[3r5v]] – TtPPase + Ca<br />
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[[2mjp]] - MjPPase + AMPPNP<br />
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**[[2mjp]] - MjPPase + AMPPNP<br />
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[[2eb0]] - MjPPase + Mn <br />
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**[[2eb0]] - MjPPase + Mn <br />
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[[1k20]] - SgPPase + Mn – ''Streptococcus gordonii''<br />
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**[[1k20]] - SgPPase + Mn – ''Streptococcus gordonii''<br />
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[[1wpp]] - SgPPase + Zn<br />
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**[[1wpp]] - SgPPase + Zn<br />
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[[1k23]] - BsPPase + Mn<br />
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**[[1k23]] - BsPPase + Mn<br />
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[[1wpn]] - BsPPase N terminal + Mn<br />
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**[[1wpn]] - BsPPase N terminal + Mn<br />
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[[2bqy]] - HpPPase + PPi<br />
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**[[2bqy]] - HpPPase + PPi<br />
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[[2uxs]] - MtPPase + PO4<br />
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**[[2uxs]] - MtPPase + PO4<br />
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[[3ej0]] - BpPPase + pyridine derivative<br />
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**[[3ej0]] - BpPPase + pyridine derivative<br />
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[[3ej2]] - BpPPase + pyrazole derivative<br />
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**[[3ej2]] - BpPPase + pyrazole derivative<br />
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[[3fq3]] - PPase + PO4 – ''Brucella melitensis''<br />
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**[[3fq3]] - PPase + PO4 – ''Brucella melitensis''<br />
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[[3ld3]] - PPase + PO4 – ''Anaplasma phagocytophilum''<br />
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**[[3ld3]] - PPase + PO4 – ''Anaplasma phagocytophilum''<br />
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[[3obc]] - PPase + Zn – ''Archaeoglobus fulgidus''<br />
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**[[3obc]] - PPase + Zn – ''Archaeoglobus fulgidus''<br />
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[[3quq]], [[3qu2]] - BtPPase + Mg<br />
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**[[3quq]], [[3qu2]] - BtPPase + Mg<br />
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[[3qut]], [[3qu4]] - BtPPase (mutant) + Mg<br />
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**[[3qut]], [[3qu4]] - BtPPase (mutant) + Mg<br />
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''Pyrophosphatase ternary complex''
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*Pyrophosphatase ternary complex
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[[1ypp]], [[1wgj]], [[1e6a]], [[1e9g]] – yPPase + PO4 + Mn<br />
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**[[1ypp]], [[1wgj]], [[1e6a]], [[1e9g]] – yPPase + PO4 + Mn<br />
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[[1m38]] - yPPase + PO4 + Co<br />
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**[[1m38]] - yPPase + PO4 + Co<br />
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[[2ihp]] - yPPase + PO4 + Mg<br />
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**[[2ihp]] - yPPase + PO4 + Mg<br />
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[[117e]], [[8prk]] - yPPase (mutant) + PO4 + Mn<br />
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**[[117e]], [[8prk]] - yPPase (mutant) + PO4 + Mn<br />
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[[2ik0]], [[2ik2]], [[2ik4]], [[2ik6]], [[2ik7]], [[2ik9]] - yPPase (mutant) + PO4 + Mg<br />
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**[[2ik0]], [[2ik2]], [[2ik4]], [[2ik6]], [[2ik7]], [[2ik9]] - yPPase (mutant) + PO4 + Mg<br />
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[[1wcf]] - MtPPase + PO4 + K<br />
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**[[1wcf]] - MtPPase + PO4 + K<br />
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[[1i6t]] - EcPPase + PPi + Ca <br />
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**[[1i6t]] - EcPPase + PPi + Ca <br />
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[[2au9]] - EcPPase + PPi + Mn<br />
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**[[2au9]] - EcPPase + PPi + Mn<br />
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[[2auu]] - EcPPase + PPi + Mg<br />
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**[[2auu]] - EcPPase + PPi + Mg<br />
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[[2au7]] – EcPPase (mutant) + PO4 + Mn<br />
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**[[2au7]] – EcPPase (mutant) + PO4 + Mn<br />
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[[2au8]] - EcPPase + PO4 + Mn<br />
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**[[2au8]] - EcPPase + PO4 + Mn<br />
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[[2haw]] - BsPPase + imidodiphosphoric acid + Mg<br />
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**[[2haw]] - BsPPase + imidodiphosphoric acid + Mg<br />
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[[3qyp]], [[3qu7]] - BtPPase (mutant) + PO4 + Ca<br />
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**[[3qyp]], [[3qu7]] - BtPPase (mutant) + PO4 + Ca<br />
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[[3qu9]] - BtPPase (mutant) + tartarate + Mg<br />
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**[[3qu9]] - BtPPase (mutant) + tartarate + Mg<br />
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[[3qx7]] - BtPPase + PO4 + Mg<br />
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**[[3qx7]] - BtPPase + PO4 + Mg<br />
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[[3tr4]] - PPase + Mg + Mn – ''Coxiella burnetii''<br />
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**[[3tr4]] - PPase + Mg + Mn – ''Coxiella burnetii''<br />
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''Pyrophosphatase quaternary complex''
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*Pyrophosphatase quaternary complex
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[[2au6]] - EcPPase + PPi + PO4 + Mn<br />
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**[[2au6]] - EcPPase + PPi + PO4 + Mn<br />
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[[2iw4]] - BsPPase + imidodiphosphoric acid + Fe + Mg + Mn<br />
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**[[2iw4]] - BsPPase + imidodiphosphoric acid + Fe + Mg + Mn<br />
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[[2enx]] - PPase + imidodiphosphoric acid + Mg + Mn – ''Streptococcus agalactiae''<br />
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**[[2enx]] - PPase + imidodiphosphoric acid + Mg + Mn – ''Streptococcus agalactiae''<br />
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[[3eiy]] - BpPPase + PPi + Na + K<br />
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**[[3eiy]] - BpPPase + PPi + Na + K<br />
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[[3gvf]] - BpPPase + PO4 + Na + K<br />
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**[[3gvf]] - BpPPase + PO4 + Na + K<br />
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[[3qxg]] - BtPPase + PO4 + Mg + Ca
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**[[3qxg]] - BtPPase + PO4 + Mg + Ca
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===NADH pyrophosphatase===
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*NADH pyrophosphatase
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[[1vk6]], [[2gb5]] – EcPPase + Zn<br />
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**[[1vk6]], [[2gb5]] – EcPPase + Zn<br />
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===Proton pyrophosphatase===
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**Proton pyrophosphatase
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[[4a01]] – PPase + imidodiphosphoric acid + Mg + K – ''Vigna radiata''
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**[[4a01]] – PPase + imidodiphosphoric acid + Mg + K – ''Vigna radiata''
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:10, 27 November 2014

Template:STRUCTURE 2bqy

Inorganic pyrophosphatase (PPase) catalyzes the breakdown of pyrophosphate (PPi) to two molecules of phosphate (PO4). The reaction releases energy and is irreversible hence it is coupled to biochemical reactions which need to be driven to completion. PPase plays a role in lipid metabolism, calcium absorption, bone formation and DNA synthesis. PPase requires a divalent metal ion like Mg+2 for higher activity. PPi is formed in many biosynthetic reactions which require ATP.

3D structures of inorganic pyrophosphatase

Updated on 27-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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