1m55
From Proteopedia
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| - | [[Image:1m55.gif|left|200px]] | + | [[Image:1m55.gif|left|200px]] |
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| - | '''Catalytic domain of the Adeno Associated Virus type 5 Rep protein''' | + | {{Structure |
| + | |PDB= 1m55 |SIZE=350|CAPTION= <scene name='initialview01'>1m55</scene>, resolution 1.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Catalytic domain of the Adeno Associated Virus type 5 Rep protein''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M55 is a [ | + | 1M55 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_5 Adeno-associated virus - 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M55 OCA]. |
==Reference== | ==Reference== | ||
| - | Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:[http:// | + | Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12191478 12191478] |
[[Category: Adeno-associated virus - 5]] | [[Category: Adeno-associated virus - 5]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: rolling circle replication]] | [[Category: rolling circle replication]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:38:59 2008'' |
Revision as of 10:39, 20 March 2008
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| , resolution 1.40Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Catalytic domain of the Adeno Associated Virus type 5 Rep protein
Overview
Adeno-associated virus (AAV), unique among animal viruses in its ability to integrate into a specific chromosomal location, is a promising vector for human gene therapy. AAV Replication (Rep) protein is essential for viral replication and integration, and its amino terminal domain possesses site-specific DNA binding and endonuclease activities required for replication initiation and integration. This domain displays a novel endonuclease fold and demonstrates an unexpected structural relationship to other viral origin binding proteins such as the papillomavirus E1 protein and the SV40 T antigen. The active site, located at the bottom of a positively charged cleft, is formed by the spatial convergence of a divalent metal ion and two conserved sequence motifs that define the rolling circle replication superfamily.
About this Structure
1M55 is a Single protein structure of sequence from Adeno-associated virus - 5. Full crystallographic information is available from OCA.
Reference
Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep., Hickman AB, Ronning DR, Kotin RM, Dyda F, Mol Cell. 2002 Aug;10(2):327-37. PMID:12191478
Page seeded by OCA on Thu Mar 20 12:38:59 2008
