Interleukin receptor

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{{#tree:id=OrganizedByTopic|openlevels=0|
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==Interleukin receptor type I==
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'''Interleukin receptor type I'''
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===Interleukin-2 receptor===
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*Interleukin-2 receptor
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[[1z92]] – hIL2R α subunit + interleukin-2<br />
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**[[1z92]] – hIL2R α subunit + interleukin-2<br />
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[[2b5i]] - hIL2R α+β+γ subunits + interleukin-2<br />
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**[[2b5i]] - hIL2R α+β+γ subunits + interleukin-2<br />
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[[3qaz]] - hIL2R β+γ subunits + interleukin-2<br />
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**[[3qaz]] - hIL2R β+γ subunits + interleukin-2<br />
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[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)<br />
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**[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)<br />
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[[3qb7]] - hIL2R γ (mutant) subunit + interleukin-2<br />
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**[[3qb7]] - hIL2R γ (mutant) subunit + interleukin-2<br />
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[[3iu3]], [[3nfp]] - hIL2R α subunit + antibody
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**[[3iu3]], [[3nfp]] - hIL2R α subunit + antibody
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===Interleukin-4 receptor===
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*Interleukin-4 receptor
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[[1iar]] - hIL4R α (mutant) subunit + interleukin-4<br />
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**[[1iar]] - hIL4R α (mutant) subunit + interleukin-4<br />
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[[3bpl]] - hIL4R α + γ subunits + interleukin-4<br />
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**[[3bpl]] - hIL4R α + γ subunits + interleukin-4<br />
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[[3bpn]] - hIL4R α subunit + hIL13R α subunit + interleukin-4<br />
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**[[3bpn]] - hIL4R α subunit + hIL13R α subunit + interleukin-4<br />
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[[3bpo]] - hIL4R α subunit + hIL13R α subunit + interleukin-13
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**[[3bpo]] - hIL4R α subunit + hIL13R α subunit + interleukin-13
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===Interleukin-5 receptor===
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*Interleukin-5 receptor
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[[3qt2]] – hIL5R α (mutant) subunit + interleukin-5<br />
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**[[3qt2]] – hIL5R α (mutant) subunit + interleukin-5<br />
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[[3va2]] - hIL5R α subunit + interleukin-5<br />
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**[[3va2]] - hIL5R α subunit + interleukin-5<br />
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===Interleukin-6 receptor or gp130===
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*Interleukin-6 receptor or gp130
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[[1i1r]] – hIL6R β subunit + interleukin-6 homolog<br />
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**[[1i1r]] – hIL6R β subunit + interleukin-6 homolog<br />
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[[1pvh]] - hIL6R β subunit + leukemia inhILbitory factor<br />
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**[[1pvh]] - hIL6R β subunit + leukemia inhILbitory factor<br />
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[[2hmh]] - mI6R β subunit + suppressor of cytokine signaling 3 – mouse<br />
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**[[2hmh]] - mI6R β subunit + suppressor of cytokine signaling 3 – mouse<br />
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[[4gl9]] - mI6R β subunit + suppressor of cytokine signaling 3 + tyrosine-protein kinase<br />
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**[[4gl9]] - mI6R β subunit + suppressor of cytokine signaling 3 + tyrosine-protein kinase<br />
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[[3l5i]], [[3l5j]], [[3l5h]] - hIL6R β subunit<br />
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**[[3l5i]], [[3l5j]], [[3l5h]] - hIL6R β subunit<br />
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[[1n26]] - hIL6R α subunit<br />
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**[[1n26]] - hIL6R α subunit<br />
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[[2arw]] - hIL6R α subunit - NMR<br />
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**[[2arw]] - hIL6R α subunit - NMR<br />
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[[1p9m]] - hIL6R α + β subunits + interleukin-6
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**[[1p9m]] - hIL6R α + β subunits + interleukin-6
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===Interleukin-7 receptor===
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*Interleukin-7 receptor
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[[3up1]] - hIL7R α subunit<br />
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**[[3up1]] - hIL7R α subunit<br />
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[[3di2]], [[3di3]] – hIL7R α (mutant) subunit + interleukin-7 (mutant)
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**[[3di2]], [[3di3]] – hIL7R α (mutant) subunit + interleukin-7 (mutant)
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===Interleukin-13 receptor===
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*Interleukin-13 receptor
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[[3lb6]] - hIL13R α2 (mutant) subunit + interleukin-13<br />
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**[[3lb6]] - hIL13R α2 (mutant) subunit + interleukin-13<br />
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[[4hwb]] - hIL13R α1 subunit + antibody<br />
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**[[4hwb]] - hIL13R α1 subunit + antibody<br />
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===Interleukin-15 receptor===
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*Interleukin-15 receptor
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[[2ers]] - hIL15R α subunit sushIL domain – NMR<br />
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**[[2ers]] - hIL15R α subunit sushIL domain – NMR<br />
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[[2z3q]], [[2z3r]], [[2psm]] - hIL15R α subunit + interleukin-15<br />
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**[[2z3q]], [[2z3r]], [[2psm]] - hIL15R α subunit + interleukin-15<br />
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[[4gs7]] - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits<br />
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**[[4gs7]] - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits<br />
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===Interleukin-17 receptor===
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*Interleukin-17 receptor
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[[3jvf]] - hIL17RA extracellular domain + interleukin-17F<br />
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**[[3jvf]] - hIL17RA extracellular domain + interleukin-17F<br />
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[[4hsa]] - hIL17RA (mutant) + interleukin-17A<br />
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**[[4hsa]] - hIL17RA (mutant) + interleukin-17A<br />
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[[3vbc]] – mIL17RB<br />
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**[[3vbc]] – mIL17RB<br />
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===Interleukin-21 receptor===
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*Interleukin-21 receptor
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[[3tgx]] – hIL21R extracellular domain (mutant) + interleukin-21
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**[[3tgx]] – hIL21R extracellular domain (mutant) + interleukin-21
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==Interleukin receptor type II==
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'''Interleukin receptor type II'''
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===Interleukin-10 receptor===
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*Interleukin-10 receptor
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[[1j7v]] – hIL10R α (mutant) subunit + interleukin-10<br />
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**[[1j7v]] – hIL10R α (mutant) subunit + interleukin-10<br />
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[[1lqs]], [[1y6m]], [[1y6n]] - hIL10R α (mutant) subunit + interleukin-10 homolog<br />
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**[[1lqs]], [[1y6m]], [[1y6n]] - hIL10R α (mutant) subunit + interleukin-10 homolog<br />
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[[1y6k ]]- hIL10R α (mutant) subunit + interleukin-10<br />
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**[[1y6k ]]- hIL10R α (mutant) subunit + interleukin-10<br />
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[[3lqm]] - hIL10R β (mutant) subunit
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**[[3lqm]] - hIL10R β (mutant) subunit
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===Interleukin-20 receptor===
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*Interleukin-20 receptor
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[[4doh]] - hIL20R α,β subunit + interleukin-20<br />
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**[[4doh]] - hIL20R α,β subunit + interleukin-20<br />
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===Interleukin-22 receptor===
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*Interleukin-22 receptor
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[[3g9v]] - hIL22R α subunit + interleukin-22<br />
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**[[3g9v]] - hIL22R α subunit + interleukin-22<br />
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[[3dgc]] – hIL22R α (mutant) subunit + interleukin-22<br />
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**[[3dgc]] – hIL22R α (mutant) subunit + interleukin-22<br />
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[[3dlq]] - hIL22R α (mutant) subunit + interleukin-2 (mutant)
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**[[3dlq]] - hIL22R α (mutant) subunit + interleukin-2 (mutant)
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===Interleukin-28 receptor===
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*Interleukin-28 receptor
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[[3og4]], [[3og6]] - hIL28R α subunit + interleukin-29<br />
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**[[3og4]], [[3og6]] - hIL28R α subunit + interleukin-29<br />
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===Interleukin receptor of immunoglobulin family===
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'''Interleukin receptor of immunoglobulin family'''
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===Interleukin-1 receptor (CD121a, CD121b)===
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*Interleukin-1 receptor (CD121a, CD121b)
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[[1itb]] – hI1R1 extracellular domain + interleukin-1 β – human<br />
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**[[1itb]] – hI1R1 extracellular domain + interleukin-1 β – human<br />
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[[1ira]]- hI1R1 extracellular domain + I1R1A<br />
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**[[1ira]]- hI1R1 extracellular domain + I1R1A<br />
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[[1g0y]] - hI1R1 extracellular domain + I1R1A peptide<br />
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**[[1g0y]] - hI1R1 extracellular domain + I1R1A peptide<br />
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[[3o4o]] - hI1R2 + interleukin-1 β<br />
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**[[3o4o]] - hI1R2 + interleukin-1 β<br />
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[[4dep]] – hIL1R1 extracellular domain + interleukin-1 β + + interleukin-1 accessory protein<br />
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**[[4dep]] – hIL1R1 extracellular domain + interleukin-1 β + + interleukin-1 accessory protein<br />
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[[4gaf]] – hIL1R1 extracellular domain + IL1β/IL1RA <br />
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**[[4gaf]] – hIL1R1 extracellular domain + IL1β/IL1RA <br />
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:32, 30 November 2014

Template:STRUCTURE 2b5i Interleukin receptors (ILR) are cytokine receptor which are classified into type I, type II and . ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses interleukin-1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).

3D structures of interleukin receptor

Updated on 30-November-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

Interleukin receptor type I

  • Interleukin-2 receptor
    • 1z92 – hIL2R α subunit + interleukin-2
    • 2b5i - hIL2R α+β+γ subunits + interleukin-2
    • 3qaz - hIL2R β+γ subunits + interleukin-2
    • 2erj - hIL2R α (mutant)+β+γ (mutant) subunits + interleukin-2 (mutant)
    • 3qb7 - hIL2R γ (mutant) subunit + interleukin-2
    • 3iu3, 3nfp - hIL2R α subunit + antibody
  • Interleukin-4 receptor
    • 1iar - hIL4R α (mutant) subunit + interleukin-4
    • 3bpl - hIL4R α + γ subunits + interleukin-4
    • 3bpn - hIL4R α subunit + hIL13R α subunit + interleukin-4
    • 3bpo - hIL4R α subunit + hIL13R α subunit + interleukin-13
  • Interleukin-5 receptor
    • 3qt2 – hIL5R α (mutant) subunit + interleukin-5
    • 3va2 - hIL5R α subunit + interleukin-5
  • Interleukin-6 receptor or gp130
    • 1i1r – hIL6R β subunit + interleukin-6 homolog
    • 1pvh - hIL6R β subunit + leukemia inhILbitory factor
    • 2hmh - mI6R β subunit + suppressor of cytokine signaling 3 – mouse
    • 4gl9 - mI6R β subunit + suppressor of cytokine signaling 3 + tyrosine-protein kinase
    • 3l5i, 3l5j, 3l5h - hIL6R β subunit
    • 1n26 - hIL6R α subunit
    • 2arw - hIL6R α subunit - NMR
    • 1p9m - hIL6R α + β subunits + interleukin-6
  • Interleukin-7 receptor
    • 3up1 - hIL7R α subunit
    • 3di2, 3di3 – hIL7R α (mutant) subunit + interleukin-7 (mutant)
  • Interleukin-13 receptor
    • 3lb6 - hIL13R α2 (mutant) subunit + interleukin-13
    • 4hwb - hIL13R α1 subunit + antibody
  • Interleukin-15 receptor
    • 2ers - hIL15R α subunit sushIL domain – NMR
    • 2z3q, 2z3r, 2psm - hIL15R α subunit + interleukin-15
    • 4gs7 - hIL15R α subunit + interleukin-15 + hIL2R β,γ subunits
  • Interleukin-17 receptor
    • 3jvf - hIL17RA extracellular domain + interleukin-17F
    • 4hsa - hIL17RA (mutant) + interleukin-17A
    • 3vbc – mIL17RB
  • Interleukin-21 receptor
    • 3tgx – hIL21R extracellular domain (mutant) + interleukin-21

Interleukin receptor type II

  • Interleukin-10 receptor
    • 1j7v – hIL10R α (mutant) subunit + interleukin-10
    • 1lqs, 1y6m, 1y6n - hIL10R α (mutant) subunit + interleukin-10 homolog
    • 1y6k - hIL10R α (mutant) subunit + interleukin-10
    • 3lqm - hIL10R β (mutant) subunit
  • Interleukin-20 receptor
    • 4doh - hIL20R α,β subunit + interleukin-20
  • Interleukin-22 receptor
    • 3g9v - hIL22R α subunit + interleukin-22
    • 3dgc – hIL22R α (mutant) subunit + interleukin-22
    • 3dlq - hIL22R α (mutant) subunit + interleukin-2 (mutant)
  • Interleukin-28 receptor
    • 3og4, 3og6 - hIL28R α subunit + interleukin-29

Interleukin receptor of immunoglobulin family

  • Interleukin-1 receptor (CD121a, CD121b)
    • 1itb – hI1R1 extracellular domain + interleukin-1 β – human
    • 1ira- hI1R1 extracellular domain + I1R1A
    • 1g0y - hI1R1 extracellular domain + I1R1A peptide
    • 3o4o - hI1R2 + interleukin-1 β
    • 4dep – hIL1R1 extracellular domain + interleukin-1 β + + interleukin-1 accessory protein
    • 4gaf – hIL1R1 extracellular domain + IL1β/IL1RA

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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