Isopropylmalate dehydrogenase
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *3-isopropylmalate dehydrogenase | |
| - | [[1ipd]], [[1xaa]], [[1xab]], [[1xac]], [[1xad]], [[1osi]], [[1dpz]], [[1dr0]], [[1dr8]], [[2y3z]] – TtIMDH – ''Thermus thermophilus''<br /> | + | **[[1ipd]], [[1xaa]], [[1xab]], [[1xac]], [[1xad]], [[1osi]], [[1dpz]], [[1dr0]], [[1dr8]], [[2y3z]] – TtIMDH – ''Thermus thermophilus''<br /> |
| - | [[1idm]], [[1osj]], [[1wal]], [[1gc8]], [[1gc9]], [[1g2u]] – TtIMDH (mutant) <br /> | + | **[[1idm]], [[1osj]], [[1wal]], [[1gc8]], [[1gc9]], [[1g2u]] – TtIMDH (mutant) <br /> |
| - | [[2ayq]], [[1v53]] – BcIMDH – ''Bacillus coagulans''<br /> | + | **[[2ayq]], [[1v53]] – BcIMDH – ''Bacillus coagulans''<br /> |
| - | [[1v5b]] – BcIMDH (mutant) <br /> | + | **[[1v5b]] – BcIMDH (mutant) <br /> |
| - | [[1cm7]] – IMDH – ''Escherichia coli''<br /> | + | **[[1cm7]] – IMDH – ''Escherichia coli''<br /> |
| - | [[1vlc]] – IMDH – ''Thermotoga maritima''<br /> | + | **[[1vlc]] – IMDH – ''Thermotoga maritima''<br /> |
| - | [[1v7l]] - IMDH – ''Pyrococcus horikoshii''<br /> | + | **[[1v7l]] - IMDH – ''Pyrococcus horikoshii''<br /> |
| - | [[1w0d]], [[2g4o]] - MtIMDH - ''Mycobacterium tuberculosis''<br /> | + | **[[1w0d]], [[2g4o]] - MtIMDH - ''Mycobacterium tuberculosis''<br /> |
| - | [[3h5e]], [[3h5h]], [[3h5j]] - MtIMDH small subunit<br /> | + | **[[3h5e]], [[3h5h]], [[3h5j]] - MtIMDH small subunit<br /> |
| - | [[2hcu]] – IMDH small subunit – ''Streptococcus mutans''<br /> | + | **[[2hcu]] – IMDH small subunit – ''Streptococcus mutans''<br /> |
| - | [[3q3w]], [[3udo]] - IMDH small subunit – ''Campylobacter jejuni''<br /> | + | **[[3q3w]], [[3udo]] - IMDH small subunit – ''Campylobacter jejuni''<br /> |
| - | [[3r8w]] - IMDH – ''Arabidopsis thaliana''<br /> | + | **[[3r8w]] - IMDH – ''Arabidopsis thaliana''<br /> |
| - | [[3u1h]] - IMDH – ''Bacillus''<br /> | + | **[[3u1h]] - IMDH – ''Bacillus''<br /> |
| - | [[3vml]] - SoIMDH – ''Shewanella oneidensis/Shewanella benthica''<br /> | + | **[[3vml]] - SoIMDH – ''Shewanella oneidensis/Shewanella benthica''<br /> |
| - | + | *IMDH binary complexes | |
| - | [[1hex]] – TtIMDH + NAD<BR /> | + | **[[1hex]] – TtIMDH + NAD<BR /> |
| - | [[2y40]] - TtIMDH + Mn<br /> | + | **[[2y40]] - TtIMDH + Mn<br /> |
| - | [[1cnz]] – IMDH + Mn – ''Salmonella typhimurium''<br /> | + | **[[1cnz]] – IMDH + Mn – ''Salmonella typhimurium''<br /> |
| - | [[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> | + | **[[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> |
| - | [[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii''<br /> | + | **[[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii''<br /> |
| - | [[4iwh]] - IMDH + Mg – ''Burkholderia thailandensis''<br /> | + | **[[4iwh]] - IMDH + Mg – ''Burkholderia thailandensis''<br /> |
| - | + | *IMDH ternary complexes | |
| - | [[2y42]] - TtIMDH + Mn + NAD<BR /> | + | **[[2y42]] - TtIMDH + Mn + NAD<BR /> |
| - | [[2ztw]] - TtIMDH + Mg + inhibitor + NAD<BR /> | + | **[[2ztw]] - TtIMDH + Mg + inhibitor + NAD<BR /> |
| - | [[2y41]] - TtIMDH + 3IPM + Mn<br /> | + | **[[2y41]] - TtIMDH + 3IPM + Mn<br /> |
| - | [[4f7i]] - TtIMDH + Mg + 3IPM + NAD<br /> | + | **[[4f7i]] - TtIMDH + Mg + 3IPM + NAD<br /> |
| - | [[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> | + | **[[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> |
| - | [[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca <br /> | + | **[[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca <br /> |
| - | [[3vmj]] - SoIMDH + 3IPM + Mg<br /> | + | **[[3vmj]] - SoIMDH + 3IPM + Mg<br /> |
| - | [[3vmk]] - IMDH + 3IPM + Mg – ''Shewanella bethica'' | + | **[[3vmk]] - IMDH + 3IPM + Mg – ''Shewanella bethica'' |
| - | + | *2-isopropylmalate dehydrogenase | |
| - | + | ||
| - | + | ||
| + | **[[3fig]] - MtIMDH (mutant) + Zn | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:57, 30 November 2014
Isopropylmalate dehydrogenase (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate. This reaction is a step in the biosynthesis of leucine in bacteria and fungi. IMDH uses NAD as a cofactor. IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation.
3D structures of isopropylmalate dehydrogenase
Updated on 30-November-2014
