This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Lactate Dehydrogenase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
- 
<StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'>
<StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'>
Line 40: Line 39:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===L-LDH===
+
*L-LDH
-
 
+
-
[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
+
-
[[2xxe]], [[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR />
+
-
[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
+
-
[[2zqy]], [[2zqz]], [[1llc]] – LcL-LDH – ''Lactobacillus casei''<BR />
+
-
[[3vku]] - LcL-LDH (mutant)<br />
+
-
[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
+
-
[[2v65]] - L-LDH A chain – ''Champsocephalus gunnari''<BR />
+
-
[[2v6b]] – L-LDH – ''Deinococcus radiodurans''<BR />
+
-
[[2frm]] – CpLDH – ''Cryptosporidium parvum''<BR />
+
-
[[1sov]], [[1pze]] - TgL-LDH – ''Toxoplasma gondii''<BR />
+
-
[[1v6a]] – L-LDH A chain – ''Cyprinus carpio''<BR />
+
-
[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
+
-
[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
+
-
[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
+
-
[[2ldx]] – C4-LDH - mouse<br />
+
-
[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br />
+
-
[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br />
+
-
[[4lmr]], [[4ln1]] - LDH – ''Bacillus cereus''<br />
+
-
[[3vpg]] – TcLDH – ''Thermus caldophilus''<br />
+
-
===L-LDH from yeast (cytochrome b2)===
+
**[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
 +
**[[2xxe]], [[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR />
 +
**[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
 +
**[[2zqy]], [[2zqz]], [[1llc]] – LcL-LDH – ''Lactobacillus casei''<BR />
 +
**[[3vku]] - LcL-LDH (mutant)<br />
 +
**[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
 +
**[[2v65]] - L-LDH A chain – ''Champsocephalus gunnari''<BR />
 +
**[[2v6b]] – L-LDH – ''Deinococcus radiodurans''<BR />
 +
**[[2frm]] – CpLDH – ''Cryptosporidium parvum''<BR />
 +
**[[1sov]], [[1pze]] - TgL-LDH – ''Toxoplasma gondii''<BR />
 +
**[[1v6a]] – L-LDH A chain – ''Cyprinus carpio''<BR />
 +
**[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
 +
**[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
 +
**[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
 +
**[[2ldx]] – C4-LDH - mouse<br />
 +
**[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br />
 +
**[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br />
 +
**[[4lmr]], [[4ln1]] - LDH – ''Bacillus cereus''<br />
 +
**[[3vpg]] – TcLDH – ''Thermus caldophilus''<br />
-
[[1kbj]] - LDH FMN-binding domain <br />
+
*L-LDH from yeast (cytochrome b2)
-
[[1sze]], [[1lco]], [[2oz0]] - LDH FMN-binding domain (mutant) <br />
+
-
[[1kbi]] - LDH FMN-binding domain + pyruvate<br />
+
-
[[1szf]], [[1ldc]] - LDH FMN-binding domain (mutant) + pyruvate<br />
+
-
[[1szg]] - LDH FMN-binding domain + sulfo-FMN<br />
+
-
[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
+
-
''L-LDH binary complex''
+
**[[1kbj]] - LDH FMN-binding domain <br />
 +
**[[1sze]], [[1lco]], [[2oz0]] - LDH FMN-binding domain (mutant) <br />
 +
**[[1kbi]] - LDH FMN-binding domain + pyruvate<br />
 +
**[[1szf]], [[1ldc]] - LDH FMN-binding domain (mutant) + pyruvate<br />
 +
**[[1szg]] - LDH FMN-binding domain + sulfo-FMN<br />
 +
**[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
-
[[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR />
+
*''L-LDH binary complex''
-
[[1cet]] - PfL-LDH + chloroquine<BR />
+
-
[[1t2c]] - PfL-LDH + NAD<BR />
+
-
[[3zh2]] - PfL-LDH + DNA aptamer<br />
+
-
[[1ez4]] - L-LDH + NAD – ''Lactobacillus pentosus''<BR />
+
-
[[1lld]], [[2ldb]] - GsL-LDH + NAD<BR />
+
-
[[2a92]] – PvL-LDH + NAD – ''Plasmodium vivax'' <BR />
+
-
[[2a94]], [[2aa3]] - PvL-LDH + NAD-analog<br />
+
-
[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
+
-
[[2xxb]] – TtL-LDH (mutant) + AMP<br />
+
-
[[3pqf]] – BsL-LDH (mutant) + NAD<br />
+
-
[[3vkv]] - LcLDH + fructose-bisphosphate<br />
+
-
[[3vpf]] – LcLDH (mutant) + pyruvate<br />
+
-
[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]] – LDH α chain + inhibitor – rat<br />
+
-
[[4ajp]], [[4m49]] – hLDH α chain + inhibitor - human<br />
+
-
[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
+
-
''L-LDH ternary complex with inhibitor''
+
**[[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR />
 +
**[[1cet]] - PfL-LDH + chloroquine<BR />
 +
**[[1t2c]] - PfL-LDH + NAD<BR />
 +
**[[3zh2]] - PfL-LDH + DNA aptamer<br />
 +
**[[1ez4]] - L-LDH + NAD – ''Lactobacillus pentosus''<BR />
 +
**[[1lld]], [[2ldb]] - GsL-LDH + NAD<BR />
 +
**[[2a92]] – PvL-LDH + NAD – ''Plasmodium vivax'' <BR />
 +
**[[2a94]], [[2aa3]] - PvL-LDH + NAD-analog<br />
 +
**[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
 +
**[[2xxb]] – TtL-LDH (mutant) + AMP<br />
 +
**[[3pqf]] – BsL-LDH (mutant) + NAD<br />
 +
**[[3vkv]] - LcLDH + fructose-bisphosphate<br />
 +
**[[3vpf]] – LcLDH (mutant) + pyruvate<br />
 +
**[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]] – LDH α chain + inhibitor – rat<br />
 +
**[[4ajp]], [[4m49]] – hLDH α chain + inhibitor - human<br />
 +
**[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
-
[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
+
*''L-LDH ternary complex with inhibitor''
-
[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR />
+
-
[[1t2e]] - PfL-LDH (mutant) + oxamate + NAD<BR />
+
-
[[1ldg]] - PfL-LDH + oxamate + NAD<BR />
+
-
[[2xxj]] – TtL-LDH (mutant) + oxamate + NAD<BR />
+
-
[[2v7p]] - TtL-LDH + oxamate + NAD<BR />
+
-
[[3om9]], [[3czm]] – TgL-LDH + OXQ + NAD<BR />
+
-
[[3h3f]] – rL-LDH A chain + oxamate + NAD <BR />
+
-
[[2fnz]] - CpLDH + oxamate + NAD<BR />
+
-
[[1t2f]] - hL-LDH B chain + azole derivative + NAD <BR />
+
-
[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
+
-
[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
+
-
[[4jnk]] - hL-LDH A chain + inhibitor + lactate + NAD<br />
+
-
[[3vph]] - TcLDH + oxamate + NAD + fructose diphosphate<br />
+
-
[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR />
+
-
[[1a5z]] - L-LDH + oxamate + NAD – ''Thermotoga maritim''a<BR />
+
-
[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR />
+
-
[[1ldn]] - GsL-LDH + oxamate + NAD<BR />
+
-
[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig
+
-
''L-LDH ternary complex with reactants''
+
**[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
 +
**[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR />
 +
**[[1t2e]] - PfL-LDH (mutant) + oxamate + NAD<BR />
 +
**[[1ldg]] - PfL-LDH + oxamate + NAD<BR />
 +
**[[2xxj]] – TtL-LDH (mutant) + oxamate + NAD<BR />
 +
**[[2v7p]] - TtL-LDH + oxamate + NAD<BR />
 +
**[[3om9]], [[3czm]] – TgL-LDH + OXQ + NAD<BR />
 +
**[[3h3f]] – rL-LDH A chain + oxamate + NAD <BR />
 +
**[[2fnz]] - CpLDH + oxamate + NAD<BR />
 +
**[[1t2f]] - hL-LDH B chain + azole derivative + NAD <BR />
 +
**[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
 +
**[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
 +
**[[4jnk]] - hL-LDH A chain + inhibitor + lactate + NAD<br />
 +
**[[3vph]] - TcLDH + oxamate + NAD + fructose diphosphate<br />
 +
**[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR />
 +
**[[1a5z]] - L-LDH + oxamate + NAD – ''Thermotoga maritim''a<BR />
 +
**[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR />
 +
**[[1ldn]] - GsL-LDH + oxamate + NAD<BR />
 +
**[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig
-
[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />
+
*''L-LDH ternary complex with reactants''
-
[[1t2d]] - PfL-LDH + oxalate + NAD<BR />
+
-
[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br />
+
-
[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br />
+
-
[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
+
-
[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
+
-
[[2fn7]] - CpLDH + lactate + NAD<BR />
+
-
[[2ewd]] - CpLDH + pyruvate + NAD-analog<br />
+
-
[[2fm3]] - CpLDH + pyruvate + NAD<BR />
+
-
[[5ldh]] - pLDH + citrate + NAD-analog<br />
+
-
[[3ldh]] - sdLDH + pyruvate + NAD<BR />
+
-
[[3pqd]] - BsLDH + fructose-bisphosphate + NAD
+
-
===D-LDH===
+
**[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />
 +
**[[1t2d]] - PfL-LDH + oxalate + NAD<BR />
 +
**[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br />
 +
**[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br />
 +
**[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
 +
**[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
 +
**[[2fn7]] - CpLDH + lactate + NAD<BR />
 +
**[[2ewd]] - CpLDH + pyruvate + NAD-analog<br />
 +
**[[2fm3]] - CpLDH + pyruvate + NAD<BR />
 +
**[[5ldh]] - pLDH + citrate + NAD-analog<br />
 +
**[[3ldh]] - sdLDH + pyruvate + NAD<BR />
 +
**[[3pqd]] - BsLDH + fructose-bisphosphate + NAD
-
[[3kb6]] – D-LDH + lactate + NAD – ''Aquifex aeolicus''<BR />
+
*D-LDH
-
[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
+
-
[[1j4a]] - LdD-LDH + sulfate<BR />
+
-
[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR />
+
-
[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''
+
-
===L-LDH II===
+
**[[3kb6]] – D-LDH + lactate + NAD – ''Aquifex aeolicus''<BR />
 +
**[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
 +
**[[1j4a]] - LdD-LDH + sulfate<BR />
 +
**[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR />
 +
**[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''
-
[[1x0a]], [[1vbi]] – TtL-LDH II
+
*L-LDH II
-
===L-Lactate/malate dehydrogenase===
+
**[[1x0a]], [[1vbi]] – TtL-LDH II
-
[[1hye]], [[1hyg]] – L-LDH/MDH – ''Methanocaldococcus jannaschi''<br />
+
*L-Lactate/malate dehydrogenase
-
[[2g8y]] - EcL-LDH/MDH
+
 +
**[[1hye]], [[1hyg]] – L-LDH/MDH – ''Methanocaldococcus jannaschi''<br />
 +
**[[2g8y]] - EcL-LDH/MDH
 +
}}
==Additional Information==
==Additional Information==
For additional information, see [[Carbohydrate Metabolism]]<br />
For additional information, see [[Carbohydrate Metabolism]]<br />

Revision as of 11:58, 30 November 2014

Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code 2fm3)

Drag the structure with the mouse to rotate

3D structures of lactate dehydrogenase

Updated on 30-November-2014

Additional Information

For additional information, see Carbohydrate Metabolism

Reference

Retrieved from "http://52.214.119.220/wiki/index.php/Lactate_Dehydrogenase"
Personal tools