Cas9
From Proteopedia
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| - | [[Cas9]] is the RNA-guided [[DNA]] [[endonuclease]] used by the CRISPR-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response. | + | [[Cas9]] is the RNA-guided [[DNA]] [[endonuclease]] used by the (CRISPR)-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response. |
It has been exploited for use in genome editing systems. | It has been exploited for use in genome editing systems. | ||
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==3D structures of Cas9== | ==3D structures of Cas9== | ||
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| + | ===''Streptococcus pyogenes'' Cas9=== | ||
* [[4un3]], [[4un4]], and [[4un5]] - ''S. pyogenes'' Cas9 bound to sgRNA and target DNA | * [[4un3]], [[4un4]], and [[4un5]] - ''S. pyogenes'' Cas9 bound to sgRNA and target DNA | ||
| - | * [[4oo8]] | + | * [[4oo8]] - - ''S. pyogenes'' Cas9 bound to sgRNA and target DNA |
* [[4cmp]] | * [[4cmp]] | ||
* [[4cmq]] - Mn<sup>2+</sup>-bound ''S. pyogenes'' Cas9 | * [[4cmq]] - Mn<sup>2+</sup>-bound ''S. pyogenes'' Cas9 | ||
Revision as of 20:40, 30 November 2014
Cas9 is the RNA-guided DNA endonuclease used by the (CRISPR)-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response.
It has been exploited for use in genome editing systems.
Articles in Proteopedia concerning Cas9 include:
- any?
Contents |
3D structures of Cas9
Streptococcus pyogenes Cas9
- 4un3, 4un4, and 4un5 - S. pyogenes Cas9 bound to sgRNA and target DNA
- 4oo8 - - S. pyogenes Cas9 bound to sgRNA and target DNA
- 4cmp
- 4cmq - Mn2+-bound S. pyogenes Cas9
Actinomyces naeslundii Cas9
See Also
References
Proteopedia Page Contributors and Editors (what is this?)
Wayne Decatur, Michal Harel, Karsten Theis, Joel L. Sussman, Ann Taylor, Thomas Gastineau
