Cas9

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[[Cas9]] is the RNA-guided [[DNA]] [[endonuclease]] used by the CRISPR(clustered regularly interspaced short palindromic repeat)-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response.
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[[Cas9]] is the RNA-guided [[DNA]] [[endonuclease]] used by the CRISPR(clustered regularly interspaced short palindromic repeats)-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response.
It has been exploited for use in genome editing systems.
It has been exploited for use in genome editing systems.

Revision as of 20:43, 30 November 2014

Cas9 is the RNA-guided DNA endonuclease used by the CRISPR(clustered regularly interspaced short palindromic repeats)-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response.

It has been exploited for use in genome editing systems.

Articles in Proteopedia concerning Cas9 include:

  • any?

Contents

3D structures of Cas9

Streptococcus pyogenes Cas9

  • 4un3, 4un4, and 4un5 - S. pyogenes Cas9 bound to sgRNA and target DNA
  • 4oo8 - - S. pyogenes Cas9 bound to sgRNA and target DNA
  • 4cmp
  • 4cmq - Mn2+-bound S. pyogenes Cas9

Actinomyces naeslundii Cas9

  • 4oge
  • 4ogc - Mn2+-bound A.s naeslundii Cas9

See Also

HNH endonuclease


References

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