Malate dehydrogenase

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The holo-MDH contains NAD or its derivatives while the apo-MDH lacks it.
The holo-MDH contains NAD or its derivatives while the apo-MDH lacks it.
-
=== Holo-MDH ===
+
* Holo-MDH
-
[[2x0r]] – HmMDH (mutant)+NAD - ''Haloarcula marismortui''<br />
+
**[[2x0r]] – HmMDH (mutant)+NAD - ''Haloarcula marismortui''<br />
-
[[1o6z]] - HmMDH (mutant)+NADH<br />
+
**[[1o6z]] - HmMDH (mutant)+NADH<br />
-
[[1hlp]] – HmMDH+NAD<br />
+
**[[1hlp]] – HmMDH+NAD<br />
-
[[1x0i]] – AfMDH+NADH – ''Archaeoglobus fulgidus''<br />
+
**[[1x0i]] – AfMDH+NADH – ''Archaeoglobus fulgidus''<br />
-
[[2x0j]] - AfMDH+etheno-NAD<br />
+
**[[2x0j]] - AfMDH+etheno-NAD<br />
-
[[1hlp]] – HmMDH+NAD<br />
+
**[[1hlp]] – HmMDH+NAD<br />
-
[[1x0i]] – AfMDH+NADH <br />
+
**[[1x0i]] – AfMDH+NADH <br />
-
[[2x0j]] - AfMDH+etheno-NAD<br />
+
**[[2x0j]] - AfMDH+etheno-NAD<br />
-
[[1ib6]], [[1ie3]] – EcMDH (mutant)+NAD - ''Escherichia coli''<br />
+
**[[1ib6]], [[1ie3]] – EcMDH (mutant)+NAD - ''Escherichia coli''<br />
-
[[1emd]] – EcMDH+NAD+citrate<br />
+
**[[1emd]] – EcMDH+NAD+citrate<br />
-
[[3i0p]] – MDH+NAD – ''Entamoeba histolytica''<br />
+
**[[3i0p]] – MDH+NAD – ''Entamoeba histolytica''<br />
-
[[3gvh]] – BmMDH+NAD – ''Brucella melitensis''<br />
+
**[[3gvh]] – BmMDH+NAD – ''Brucella melitensis''<br />
-
[[3gvi]] - BmMDH+ADP<br />
+
**[[3gvi]] - BmMDH+ADP<br />
-
[[2hjr]] – MDH+adenosine diphosphoribose – ''Cryptosporidium parvum''<br />
+
**[[2hjr]] – MDH+adenosine diphosphoribose – ''Cryptosporidium parvum''<br />
-
[[2dfd]] – MDH+NAD – human type 2<br />
+
**[[2dfd]] – MDH+NAD – human type 2<br />
-
[[1wze]] – TfMDH (mutant)+NAD – ''Thermus flavus''<br />
+
**[[1wze]] – TfMDH (mutant)+NAD – ''Thermus flavus''<br />
-
[[1wzi]] - TfMDH (mutant)+NDP<br />
+
**[[1wzi]] - TfMDH (mutant)+NDP<br />
-
[[1bdm]] - TfMDH (mutant)+beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide<br />
+
**[[1bdm]] - TfMDH (mutant)+beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide<br />
-
[[1bmd]] – TfMDH+NAD<br />
+
**[[1bmd]] – TfMDH+NAD<br />
-
[[1y7t]] – TtMDH+NADPH – ''Thermus thermophilus''<br />
+
**[[1y7t]] – TtMDH+NADPH – ''Thermus thermophilus''<br />
-
[[2cvq]] - TtMDH+NADP<br />
+
**[[2cvq]] - TtMDH+NADP<br />
-
[[1v9n]] – MDH+NADPH – ''Pyrococcus horikoshii''<br />
+
**[[1v9n]] – MDH+NADPH – ''Pyrococcus horikoshii''<br />
-
[[1z2i]] – MDH+NAD – ''Agrobacterium tumefaciens''<br />
+
**[[1z2i]] – MDH+NAD – ''Agrobacterium tumefaciens''<br />
-
[[1uxg]], [[1uxh]], [[1uxi]], [[1uxj]], [[1uxk]], [[1ur5]] – ChaMDH (mutant)+NAD – ''Chloroflexus aurantiacus''<br />
+
**[[1uxg]], [[1uxh]], [[1uxi]], [[1uxj]], [[1uxk]], [[1ur5]] – ChaMDH (mutant)+NAD – ''Chloroflexus aurantiacus''<br />
-
[[1guz]], [[1guy]], [[1gv0]] – CvMDH+NAD – ''Chlorobium vibrioforme''<br />
+
**[[1guz]], [[1guy]], [[1gv0]] – CvMDH+NAD – ''Chlorobium vibrioforme''<br />
-
[[1civ]] – MDH+NADP – ''Flaveria bidentis''<br />
+
**[[1civ]] – MDH+NADP – ''Flaveria bidentis''<br />
-
[[1b8u]], [[1b8v]] – AaMDH+NAD - ''Aquaspirillum arcticum''<br />
+
**[[1b8u]], [[1b8v]] – AaMDH+NAD - ''Aquaspirillum arcticum''<br />
-
[[5mdh]] – SsMDH+NAD+alpha-ketomalonic acid – ''Sus scrofa''<br />
+
**[[5mdh]] – SsMDH+NAD+alpha-ketomalonic acid – ''Sus scrofa''<br />
-
[[4mdh]] – SsMDH+NAD<br />
+
**[[4mdh]] – SsMDH+NAD<br />
-
[[4i1i]] – LmMd + NAD – ''Leishmania major''
+
**[[4i1i]] – LmMd + NAD – ''Leishmania major''
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=== apo-MDH ===
+
* apo-MDH
-
 
+
-
[[2j5r]], [[2j5k]], [[2j5q]], [[1d3a]], [[4jco]] – HmMDH <br />
+
-
[[2hlp]] – HmMDH (mutant)<br />
+
-
[[3hhp]], [[2pwz]] – EcMDH <br />
+
-
[[3fi9]] – MDH – ''Porphyromonas gingivalis'' <br />
+
-
[[3d5t]] - MDH – ''Burkholderia pseudomallei''<br />
+
-
[[2d4a]] – MDH – ''Aeropyrum pernix''<br />
+
-
[[1iz9]], [[4kde]], [[4kdf]] - TtMDH<br />
+
-
[[1sev]], [[1smk]] – MDH – ''Citrullus lanatus''<br />
+
-
[[1gv1]] – CvMDH <br />
+
-
[[1b8p]] – AaMDH <br />
+
-
[[7mdh]] – MDH – Sorgum bicolor<br />
+
-
[[1mld]] – SsMDH<br />
+
-
[[2cmd]] - EcMd+citrate<br />
+
-
[[3nep]] – Md – ''Salinibacter ruber''<br />
+
-
[[3p7m]] – Md – ''Francisella tularensis''<br />
+
-
[[3tl2]] – Md – ''Bacillus anthracis''<br />
+
-
[[4e0b]] – Md – ''Vibrio vulnificus''<br />
+
-
[[4h7p]] - LmMd<br />
+
-
[[4bgt]] – CaMd <br />
+
-
[[4cl3]] – ChaMd <br />
+
 +
**[[2j5r]], [[2j5k]], [[2j5q]], [[1d3a]], [[4jco]] – HmMDH <br />
 +
**[[2hlp]] – HmMDH (mutant)<br />
 +
**[[3hhp]], [[2pwz]] – EcMDH <br />
 +
**[[3fi9]] – MDH – ''Porphyromonas gingivalis'' <br />
 +
**[[3d5t]] - MDH – ''Burkholderia pseudomallei''<br />
 +
**[[2d4a]] – MDH – ''Aeropyrum pernix''<br />
 +
**[[1iz9]], [[4kde]], [[4kdf]] - TtMDH<br />
 +
**[[1sev]], [[1smk]] – MDH – ''Citrullus lanatus''<br />
 +
**[[1gv1]] – CvMDH <br />
 +
**[[1b8p]] – AaMDH <br />
 +
**[[7mdh]] – MDH – Sorgum bicolor<br />
 +
**[[1mld]] – SsMDH<br />
 +
**[[2cmd]] - EcMd+citrate<br />
 +
**[[3nep]] – Md – ''Salinibacter ruber''<br />
 +
**[[3p7m]] – Md – ''Francisella tularensis''<br />
 +
**[[3tl2]] – Md – ''Bacillus anthracis''<br />
 +
**[[4e0b]] – Md – ''Vibrio vulnificus''<br />
 +
**[[4h7p]] - LmMd<br />
 +
**[[4bgt]] – CaMd <br />
 +
**[[4cl3]] – ChaMd <br />
 +
}}
==Additional Resources==
==Additional Resources==
For additional information, see: [[Carbohydrate Metabolism]]
For additional information, see: [[Carbohydrate Metabolism]]

Revision as of 07:38, 1 December 2014

Malate dehydrogenase complex with NAD, sulfate and Na+ ion (purple) (PDB code 2x0i)

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3D Structures of Malate Dehydrogenase

Updated on 01-December-2014 The holo-MDH contains NAD or its derivatives while the apo-MDH lacks it.

Additional Resources

For additional information, see: Carbohydrate Metabolism

References

  1. ↑ Minarik P, Tomaskova N, Kollarova M, Antalik M. Malate dehydrogenases--structure and function. Gen Physiol Biophys. 2002 Sep;21(3):257-65. PMID:12537350
  2. ↑ Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T. Dictyostelium Differentiation-Inducing Factor-1 Binds to Mitochondrial Malate Dehydrogenase and Inhibits Its Activity. J Pharmacol Sci. 2010 Feb 20. PMID:20173310
  3. ↑ Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T. Dictyostelium Differentiation-Inducing Factor-1 Binds to Mitochondrial Malate Dehydrogenase and Inhibits Its Activity. J Pharmacol Sci. 2010 Feb 20. PMID:20173310
  4. ↑ Musrati RA, Kollarova M, Mernik N, Mikulasova D. Malate dehydrogenase: distribution, function and properties. Gen Physiol Biophys. 1998 Sep;17(3):193-210. PMID:9834842
  5. ↑ Boernke WE, Millard CS, Stevens PW, Kakar SN, Stevens FJ, Donnelly MI. Stringency of substrate specificity of Escherichia coli malate dehydrogenase. Arch Biochem Biophys. 1995 Sep 10;322(1):43-52. PMID:7574693 doi:http://dx.doi.org/10.1006/abbi.1995.1434
  6. ↑ Plancarte A, Nava G, Mendoza-Hernandez G. Purification, properties, and kinetic studies of cytoplasmic malate dehydrogenase from Taenia solium cysticerci. Parasitol Res. 2009 Jul;105(1):175-83. Epub 2009 Mar 10. PMID:19277715 doi:10.1007/s00436-009-1380-6
  7. ↑ Goward CR, Nicholls DJ. Malate dehydrogenase: a model for structure, evolution, and catalysis. Protein Sci. 1994 Oct;3(10):1883-8. PMID:7849603 doi:http://dx.doi.org/10.1002/pro.5560031027
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