MECDP synthase
From Proteopedia
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *'''MECPS''' | |
| - | [[1knk]] - EcMECPS + Mn – ''Escherichia coli''<br /> | + | **[[1knk]] - EcMECPS + Mn – ''Escherichia coli''<br /> |
| - | [[1u3p]] - EcMECPS + Zn<br /> | + | **[[1u3p]] - EcMECPS + Zn<br /> |
| - | [[3f0d]] - BpMECPS + Zn – ''Burkholderia pseudomallei''<br /> | + | **[[3f0d]] - BpMECPS + Zn – ''Burkholderia pseudomallei''<br /> |
| - | [[3f0e]] - BpMECPS + Mg + Zn<br /> | + | **[[3f0e]] - BpMECPS + Mg + Zn<br /> |
| - | [[1jn1]] - HiMECPS + Co – ''Haemophilus influenzae'' <br /> | + | **[[1jn1]] - HiMECPS + Co – ''Haemophilus influenzae'' <br /> |
| - | [[1vh8]] - HiMECPS <br /> | + | **[[1vh8]] - HiMECPS <br /> |
| - | [[1vha]] - HiMECPS + Mn<br /> | + | **[[1vha]] - HiMECPS + Mn<br /> |
| - | [[1iv1]] - TtMECPS – ''Thermus thermophilus''<br /> | + | **[[1iv1]] - TtMECPS – ''Thermus thermophilus''<br /> |
| - | [[3f6m]] - YpMECPS – ''Yersinia pestis''<br /> | + | **[[3f6m]] - YpMECPS – ''Yersinia pestis''<br /> |
| - | [[1iv3]] - TtMECPS (mutant) + Mg<br /> | + | **[[1iv3]] - TtMECPS (mutant) + Mg<br /> |
| - | [[3ghz]] - MECPS + Mg – ''Salmonella typhimurium''<br /> | + | **[[3ghz]] - MECPS + Mg – ''Salmonella typhimurium''<br /> |
| - | [[3re3]] - MECPS – ''Francisella tularensis''<br /> | + | **[[3re3]] - MECPS – ''Francisella tularensis''<br /> |
| - | [[4c82]] - PfMECPS (mutant) + Zn – ''Plasmodium falciparum''<br /> | + | **[[4c82]] - PfMECPS (mutant) + Zn – ''Plasmodium falciparum''<br /> |
| - | + | *MECPS binary complex | |
| - | [[1gx1]] - EcMECPS + CDP + Mn + Zn<br /> | + | **[[1gx1]] - EcMECPS + CDP + Mn + Zn<br /> |
| - | [[1u3l]] - EcMECPS + CDP + Mg + Zn<br /> | + | **[[1u3l]] - EcMECPS + CDP + Mg + Zn<br /> |
| - | [[3f0f]] - BpMECPS + CMP + Mg + Zn<br /> | + | **[[3f0f]] - BpMECPS + CMP + Mg + Zn<br /> |
| - | [[3ike]] - BpMECPS + cytosine + Mg + Zn<br /> | + | **[[3ike]] - BpMECPS + cytosine + Mg + Zn<br /> |
| - | [[3k2x]], [[3ke1]] - BpMECPS + cytosine derivative + Zn<br /> | + | **[[3k2x]], [[3ke1]] - BpMECPS + cytosine derivative + Zn<br /> |
| - | [[3ikf]], [[3k14]], [[3q8h]] - BpMECPS + imidazo-thiazol derivative + Zn<br /> | + | **[[3ikf]], [[3k14]], [[3q8h]] - BpMECPS + imidazo-thiazol derivative + Zn<br /> |
| - | [[3f0g]], [[3ieq]] - BpMECPS + CMP + Zn<br /> | + | **[[3f0g]], [[3ieq]] - BpMECPS + CMP + Zn<br /> |
| - | [[2uzh]] - MECPS + CDP + Zn – ''Mycobacterium smegmatis''<br /> | + | **[[2uzh]] - MECPS + CDP + Zn – ''Mycobacterium smegmatis''<br /> |
| - | [[4c81]] - PfMECPS (mutant) + CDP + Zn <br /> | + | **[[4c81]] - PfMECPS (mutant) + CDP + Zn <br /> |
| - | [[3fpi]] - YpMECPS + CTP + Mg<br /> | + | **[[3fpi]] - YpMECPS + CTP + Mg<br /> |
| - | [[1iv2]] - TtMECPS (mutant) + CDP + Mg<br /> | + | **[[1iv2]] - TtMECPS (mutant) + CDP + Mg<br /> |
| - | [[1iv4]] - TtMECPS (mutant) + CMP + Mg<br /> | + | **[[1iv4]] - TtMECPS (mutant) + CMP + Mg<br /> |
| - | [[1h47]] - EcMECPS + CMP + Zn<br /> | + | **[[1h47]] - EcMECPS + CMP + Zn<br /> |
| - | [[3jvh]] - BpMECPS + pyrimidine derivative + Zn<br /> | + | **[[3jvh]] - BpMECPS + pyrimidine derivative + Zn<br /> |
| - | [[1u40]] - EcMECPS + CDME + Zn<br /> | + | **[[1u40]] - EcMECPS + CDME + Zn<br /> |
| - | [[1u43]] - EcMECPS + 2P-CDME<br /> | + | **[[1u43]] - EcMECPS + 2P-CDME<br /> |
| - | [[1t0a]] - MECPS + farnesyl phosphate + Co + Zn - ''Shewanella oneidensis''<br /> | + | **[[1t0a]] - MECPS + farnesyl phosphate + Co + Zn - ''Shewanella oneidensis''<br /> |
| - | [[2pmp]] - MECPS + CMP + Zn – ''Arabidopsis thaliana''<br /> | + | **[[2pmp]] - MECPS + CMP + Zn – ''Arabidopsis thaliana''<br /> |
| - | [[4c8e]], [[4c8g]] - BcMECPS + CMP + Zn – ''Burkholderia cenocepacia''<br /> | + | **[[4c8e]], [[4c8g]] - BcMECPS + CMP + Zn – ''Burkholderia cenocepacia''<br /> |
| - | [[4c8i]] - BcMECPS + citrate + Zn <br /> | + | **[[4c8i]] - BcMECPS + citrate + Zn <br /> |
| - | + | *MECPS ternary complex | |
| - | [[3iew]] - BpMECPS + CDP + CTP + Zn<br /> | + | **[[3iew]] - BpMECPS + CDP + CTP + Zn<br /> |
| - | [[1jy8]] – EcMECPS + MECP + CMP + Zn<br /> | + | **[[1jy8]] – EcMECPS + MECP + CMP + Zn<br /> |
| - | [[1knj]] - EcMECPS + MECP + CMP + Mn<br /> | + | **[[1knj]] - EcMECPS + MECP + CMP + Mn<br /> |
| - | [[3mbm]] - BpMECPS + imidazo-thiazol derivative +cytosine + Zn<br /> | + | **[[3mbm]] - BpMECPS + imidazo-thiazol derivative +cytosine + Zn<br /> |
| - | [[3p10]] - BpMECPS + pyrimidine derivative + cytidine + Zn<br /> | + | **[[3p10]] - BpMECPS + pyrimidine derivative + cytidine + Zn<br /> |
| - | [[3t80]] - MECPS + pyrimidine derivative + cytidine + Zn – ''Salmonella enterica''<br /> | + | **[[3t80]] - MECPS + pyrimidine derivative + cytidine + Zn – ''Salmonella enterica''<br /> |
| - | [[1yqn]] – EcMECPS (mutant) + CMP + geranyl diphosphate + Mn + Zn<br /> | + | **[[1yqn]] – EcMECPS (mutant) + CMP + geranyl diphosphate + Mn + Zn<br /> |
| - | [[2amt]] - EcMECPS + CMP derivative + geranyl diphosphate + Zn<br /> | + | **[[2amt]] - EcMECPS + CMP derivative + geranyl diphosphate + Zn<br /> |
| - | [[3elc]], [[3eor]], [[3ern]], [[3fba]] - EcMECPS + pyrimidine derivative + geranyl diphosphate + Zn<br /> | + | **[[3elc]], [[3eor]], [[3ern]], [[3fba]] - EcMECPS + pyrimidine derivative + geranyl diphosphate + Zn<br /> |
| - | [[3esj]] - EcMECPS + pyrimidine derivative + geranyl diphosphate + Mg + Zn<br /> | + | **[[3esj]] - EcMECPS + pyrimidine derivative + geranyl diphosphate + Mg + Zn<br /> |
| - | [[2gzl]] - EcMECPS + inhibitor + geranyl diphosphate + Zn<br /> | + | **[[2gzl]] - EcMECPS + inhibitor + geranyl diphosphate + Zn<br /> |
| - | + | *MECPS quaternary complex | |
| - | + | ||
| - | + | ||
| - | + | ||
| + | **[[3p0z]], [[3qhd]] - BpMECPS + imidazo derivative + pyrimidine derivative + cytidine + Zn<br /> | ||
| + | **[[1h48]] - EcMECPS + MECP + CMP + geranyl diphosphate + Mn + Zn<br /> | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:22, 1 December 2014
MECDP synthase (MECPS) participates in mevalonate-independent steroid biosynthesis. It converts 2-phospho-4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol (2P-CDME) to 2-C-methyl-D-erythritol 2, 4-cyclodiphosphate (MECP) and CMP. MECPS contains metal binding sites which are required for catalysis. MECPS is a potential antimalarial drug target.
3D structures of MECDP synthase
Updated on 01-December-2014
