Mitogen-activated protein kinase kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===MAP2K1===
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*MAP2K1
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[[3mbl]], [[3e8n]], [[3dy7]], [[3eqb]], [[2p55]], [[4ark]] – hMAP2K1 kinase domain +MgADP+ligand - human<br />
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**[[3mbl]], [[3e8n]], [[3dy7]], [[3eqb]], [[2p55]], [[4ark]] – hMAP2K1 kinase domain +MgADP+ligand - human<br />
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[[3eqc]] – hMAP2K1 kinase domain+ATP-Gs+Mg2P<br />
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**[[3eqc]] – hMAP2K1 kinase domain+ATP-Gs+Mg2P<br />
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[[3eqd]] - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P<br />
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**[[3eqd]] - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P<br />
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[[3eqf]] - hMAP2K1 kinase domain (mutant)+inhibitor+Mg2P<br />
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**[[3eqf]] - hMAP2K1 kinase domain (mutant)+inhibitor+Mg2P<br />
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[[3eqg]], [[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br />
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**[[3eqg]], [[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br />
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[[3eqh]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor<br />
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**[[3eqh]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor<br />
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[[3orn]], [[4lmn]], [[3wig]] - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor<br />
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**[[3orn]], [[4lmn]], [[3wig]] - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor<br />
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[[3sls]] – hMAP2K1 kinase domain (mutant) + Mg + AMPPNP + inhibitor<br />
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**[[3sls]] – hMAP2K1 kinase domain (mutant) + Mg + AMPPNP + inhibitor<br />
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[[4an2]], [[4an3]], [[4an9]], [[4anb]] – hMAP2K1 kinase domain (mutant) + Mg + ACP + inhibitor<br />
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**[[4an2]], [[4an3]], [[4an9]], [[4anb]] – hMAP2K1 kinase domain (mutant) + Mg + ACP + inhibitor<br />
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[[3zls]], [[3zlw]], [[3zlx]], [[3zly]], [[3zm4]] – hMAP2K1 kinase domain + inhibitor<br />
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**[[3zls]], [[3zlw]], [[3zlx]], [[3zly]], [[3zm4]] – hMAP2K1 kinase domain + inhibitor<br />
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[[3os3]], [[3pp1]], [[3v01]], [[3v04]], [[3vvh]] - hMAP2K1 kinase domain + MgATP +inhibitor<br />
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**[[3os3]], [[3pp1]], [[3v01]], [[3v04]], [[3vvh]] - hMAP2K1 kinase domain + MgATP +inhibitor<br />
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[[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br />
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**[[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br />
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[[3dv3]] - hMAP2K1 residues 62-382+inhibitor<br />
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**[[3dv3]] - hMAP2K1 residues 62-382+inhibitor<br />
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[[1s9j]] – hMAP2K1 +MgATP+ligand<br />
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**[[1s9j]] – hMAP2K1 +MgATP+ligand<br />
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[[3w8q]] – hMAP2K1 + ATP-γS <br />
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**[[3w8q]] – hMAP2K1 + ATP-γS <br />
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[[1sko]] - hMAP2K1+P14<br />
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**[[1sko]] - hMAP2K1+P14<br />
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[[3cpt]] - hMAP2K1+P14 (mutant)<br />
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**[[3cpt]] - hMAP2K1+P14 (mutant)<br />
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[[2y4i]] – MAP2K1 + kinase suppressor of RAS 2 - rabbit<br />
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**[[2y4i]] – MAP2K1 + kinase suppressor of RAS 2 - rabbit<br />
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[[1vet]], [[1veu]] - mMAP2K1+P14 - mouse<br />
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**[[1vet]], [[1veu]] - mMAP2K1+P14 - mouse<br />
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[[4mne]] – hMAP2K1 + Mg + ATP-γS + proto-oncogene B-raf<br />
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**[[4mne]] – hMAP2K1 + Mg + ATP-γS + proto-oncogene B-raf<br />
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===MAP2K2===
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*MAP2K2
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[[1s9i]] – hMAP2K2 +MgATP+ligand<br />
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**[[1s9i]] – hMAP2K2 +MgATP+ligand<br />
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[[1jky]] - hMAP2K2 + Anthrax lethal factor
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**[[1jky]] - hMAP2K2 + Anthrax lethal factor
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===MAP2K3===
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*MAP2K3
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[[2o2v]] – hMAP2K3+ hMAP3K5<br />
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**[[2o2v]] – hMAP2K3+ hMAP3K5<br />
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===MAP2K4===
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*MAP2K4
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[[3aln]] - hMAP2K4 kinase domain +AMPPNP<br />
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**[[3aln]] - hMAP2K4 kinase domain +AMPPNP<br />
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[[3alo]] - hMAP2K4 kinase domain + P38 peptide
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**[[3alo]] - hMAP2K4 kinase domain + P38 peptide
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===MAP2K5===
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*MAP2K5
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[[1wi0]] - mMAP2K5 PB1 domain – NMR<br />
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**[[1wi0]] - mMAP2K5 PB1 domain – NMR<br />
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[[1p38]] – hMAP2K5+hMAP2KK2<br />
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**[[1p38]] – hMAP2K5+hMAP2KK2<br />
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===MAP2K6===
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*MAP2K6
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[[3an0]] - hMAP2K6<br />
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**[[3an0]] - hMAP2K6<br />
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[[3enm]] – hMAP2K6 (mutant)<br />
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**[[3enm]] – hMAP2K6 (mutant)<br />
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[[3fme]] – hMAP2K6 kinase domain (mutant)<br />
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**[[3fme]] – hMAP2K6 kinase domain (mutant)<br />
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===MAP2K7===
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*MAP2K7
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[[2dyl]] – hMAP2K7 kinase domain (mutant)<br />
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**[[2dyl]] – hMAP2K7 kinase domain (mutant)<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:41, 1 December 2014

Image:3e8n.png
Crystal Structure of the Mitogen-activated protein kinase kinase, 3e8n

Template:STRUCTURE 1sko
















Mitogen-activated protein kinase kinase (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of MAPK and MAP3K which are activated by phosphorylation. MAP2K activates MAPK.







3D Structures of Mitogen-activated protein kinase kinase

Updated on 01-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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