Mitogen-activated protein kinase kinase kinase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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=== MAP3K1 ===
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* MAP3K1
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[[1uti]] - MAP3K1+GRB2-related adaptor protein 2 - mouse
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**[[1uti]] - MAP3K1+GRB2-related adaptor protein 2 - mouse
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===MAP3K2 ===
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*MAP3K2
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[[2cu1]] - hMAP3K2 PB1 domain (mutant) - human - NMR<br />
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**[[2cu1]] - hMAP3K2 PB1 domain (mutant) - human - NMR<br />
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[[2o2v]], [[1p38]] – hMAP3K2+hMAP3K5 - human<br />
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**[[2o2v]], [[1p38]] – hMAP3K2+hMAP3K5 - human<br />
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[[2npt]] - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain
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**[[2npt]] - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain
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===MAP3K3 ===
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*MAP3K3
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[[2c60]] – hMAP3K3 PHOX domain<br />
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**[[2c60]] – hMAP3K3 PHOX domain<br />
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[[2jrh]] - hMAP3K3 PB1 domain<br />
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**[[2jrh]] - hMAP3K3 PB1 domain<br />
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[[2pph]] - hMAP3K3 PB1 domain - NMR
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**[[2pph]] - hMAP3K3 PB1 domain - NMR
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===MAP3K5 ===
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*MAP3K5
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[[2clq]] – hMAP3K5<br />
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**[[2clq]] – hMAP3K5<br />
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[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]] - hMAP3K5 (mutant) + inhibitor<br />
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**[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]] - hMAP3K5 (mutant) + inhibitor<br />
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===MAP3K7===
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*MAP3K7
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[[2eva]] – hMAP3K7/MAP3K7-interacting protein
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**[[2eva]] – hMAP3K7/MAP3K7-interacting protein
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===MAP3K9 ===
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*MAP3K9
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[[3dtc]] - hMAP3K9 (mutant) + inhibitor
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**[[3dtc]] - hMAP3K9 (mutant) + inhibitor
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===MAP3K10 ===
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*MAP3K10
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[[2rf0]] - hMAP3K10 SH3 domain - NMR
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**[[2rf0]] - hMAP3K10 SH3 domain - NMR
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===MAP3K14===
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*MAP3K14
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[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br />
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[[4idt]], [[4idv]] - hMAP3K14 + inhibitor<br />
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**[[4dn5]] - hMAP3K14 (mutant) + ATP-γ-S<br />
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**[[4idt]], [[4idv]] - hMAP3K14 + inhibitor<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:46, 1 December 2014

Image:2clq.png
Crystal Structure of the Mitogen-activated protein kinase kinase kinase, 2clq

Template:STRUCTURE 2o2v

















Mitogen-activated protein kinase kinase kinase (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K.

3D Structures of Mitogen-activated protein kinase kinase

Updated on 01-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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