Priyanka Basak/Sandbox
From Proteopedia
(Difference between revisions)
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==Introduction== | ==Introduction== | ||
<StructureSection load='3tj8' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3tj8' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | ''Helicobacter pylori'' ('' | + | ''Helicobacter pylori'' (''H.pylori'') is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. Several accessory proteins play a crucial role in the maturation of Urease. UreE is urease-specific Nickel metallochaperone that is involved in the delivery nickel to urease. |
== Function == | == Function == | ||
UreE delivers Nickel to urease. | UreE delivers Nickel to urease. | ||
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== Structural highlights == | == Structural highlights == | ||
| + | Apo-UreE from ''H.pylori'' is a dimer which becomes tetrameric (dimer of dimer) when bound to metal and binds one Ni(II) per dimer. The nickel binding site is six-coordinate. | ||
== Headline text == | == Headline text == | ||
Revision as of 17:22, 2 December 2014
UreE: A Nickel Metallochaperone for Urease
Introduction
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References
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