Priyanka Basak/Sandbox
From Proteopedia
(Difference between revisions)
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==Introduction== | ==Introduction== | ||
<StructureSection load='3tj8' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3tj8' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | ''Helicobacter pylori'' (''H.pylori'') is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. Several accessory proteins play a crucial role in the maturation of Urease. UreE is urease-specific Nickel metallochaperone that is involved in the delivery nickel to urease. | + | UreE is an essential metallochaeprone for ''Helicobacter pylori'' (''H.pylori''). ''H.pylori'' is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. Several accessory proteins play a crucial role in the maturation of Urease. UreE is urease-specific Nickel metallochaperone that is involved in the delivery nickel to urease. |
== Function == | == Function == | ||
UreE delivers Nickel to urease. | UreE delivers Nickel to urease. | ||
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== References == | == References == | ||
| - | < | + | <http://www.ncbi.nlm.nih.gov/pubmed/20681615/> |
[http://] | [http://] | ||
Revision as of 19:27, 2 December 2014
UreE: A Nickel Metallochaperone for Urease
Introduction
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