Priyanka Basak/Sandbox
From Proteopedia
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Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific nickel metallochaperone that is involved in the delivery nickel to urease. | Several accessory proteins play a crucial role in the maturation of Urease. UreE is a urease-specific nickel metallochaperone that is involved in the delivery nickel to urease. | ||
== Structural highlights == | == Structural highlights == | ||
| - | Apo-UreE from ''H.pylori'' is a dimer.[[Image:HpUreE.png | + | Apo-UreE from ''H.pylori'' is a dimer.[[Image:HpUreE.png]] ''Hp''UreE can bind one Ni(II) per dimer <scene name='60/609775/Nickel_bound_uree/5'>Nickel bound UreE</scene>. Nickel is bound to UreE in an octahedral fashion with one His from one subunit and two His from other subunit <scene name='60/609775/Nickel_bound_uree_2/2'>(UreE-Nickel Binding site)</scene>.In presence of Ni, its oligomeric state changes to a tetramer (dimer of dimer). |
Revision as of 20:26, 2 December 2014
Introduction
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