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Phosphodiesterase

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{{#tree:id=OrganizedByTopic|openlevels=0|
-
===cAMP PDE===
+
*cAMP PDE
-
[[1loi]] – rPDE N terminal – rat – NMR<BR />
+
**[[1loi]] – rPDE N terminal – rat – NMR<BR />
-
[[3ib7]] – MtPDE – ''Mycobacterium tuberculosis''<BR />
+
**[[3ib7]] – MtPDE – ''Mycobacterium tuberculosis''<BR />
-
[[3ib8]] – MtPDE + AMP
+
**[[3ib8]] – MtPDE + AMP
-
===cGMP PDE===
+
*cGMP PDE
-
[[1ksg]], [[1ksh]], [[1ksj]] – hPDE δ subunit + ARF-like protein - human<BR />
+
**[[1ksg]], [[1ksh]], [[1ksj]] – hPDE δ subunit + ARF-like protein - human<BR />
-
[[2ju4]] - PDE γ subunit – bovine - NMR<BR />
+
**[[2ju4]] - PDE γ subunit – bovine - NMR<BR />
-
[[4kie]], [[4lyk]] - EcPDE EAL domain – ''Escherichia coli''<br />
+
**[[4kie]], [[4lyk]] - EcPDE EAL domain – ''Escherichia coli''<br />
-
[[4lj3]] - EcPDE EAL domain + GMP<br />
+
**[[4lj3]] - EcPDE EAL domain + GMP<br />
-
===PDE 1===
+
*PDE 1
-
[[1taz]] – hPDE 1b catalytic domain – human<BR />
+
**[[1taz]] – hPDE 1b catalytic domain – human<BR />
-
[[2r8q]] - PDE 1b catalytic domain + inhibitor – ''Leishmania major''<br />
+
**[[2r8q]] - PDE 1b catalytic domain + inhibitor – ''Leishmania major''<br />
-
[[4i15]] – PDE catalytic domain – ''Trypanosoma brucei''<br />
+
**[[4i15]] – PDE catalytic domain – ''Trypanosoma brucei''<br />
-
===PDE 2===
+
*PDE 2
-
[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR />
+
**[[1f0j]] – mPDE 2a regulatory domain (mutant) – mouse<BR />
-
[[1z1l]], [[3ibj]], [[3itm]] - hPDE 2a catalytic domain<BR />
+
**[[1z1l]], [[3ibj]], [[3itm]] - hPDE 2a catalytic domain<BR />
-
[[3itu]], [[4htx]], [[4htz]], [[4jib]] - hPDE 2a catalytic domain + inhibitor<br />
+
**[[3itu]], [[4htx]], [[4htz]], [[4jib]] - hPDE 2a catalytic domain + inhibitor<br />
-
===PDE 3===
+
*PDE 3
-
[[1so2]], [[1soj]] – hPDE 3b catalytic domain + inhibitor<br />
+
**[[1so2]], [[1soj]] – hPDE 3b catalytic domain + inhibitor<br />
-
===PDE 4a===
+
*PDE 4a
-
[[3i8v]], [[3tvx]] – hPDE 4a catalytic domain + inhibitor<br />
+
**[[3i8v]], [[3tvx]] – hPDE 4a catalytic domain + inhibitor<br />
-
===PDE 4b===
+
*PDE 4b
-
[[1f0j]] – hPDE 4b catalytic domain (mutant) <BR />
+
**[[1f0j]] – hPDE 4b catalytic domain (mutant) <BR />
-
[[1ro6]], [[1xmy]], [[1xn0]] - hPDE 4b catalytic domain + anti-inflammatory drug<br />
+
**[[1ro6]], [[1xmy]], [[1xn0]] - hPDE 4b catalytic domain + anti-inflammatory drug<br />
-
[[1xot]] - hPDE 4b catalytic domain + drug<br />
+
**[[1xot]] - hPDE 4b catalytic domain + drug<br />
-
[[1tb5]], [[1ro9]], [[1ror]] - hPDE 4b catalytic domain + AMP<BR />
+
**[[1tb5]], [[1ro9]], [[1ror]] - hPDE 4b catalytic domain + AMP<BR />
-
[[1y2h]], [[1y2j]], [[2qyl]], [[3d3p]], [[3kkt]], [[3frg]], [[3gwt]], [[3ly2]], [[3hmv]], [[3o56]], [[3o57]], [[3o0j]], [[3w5e]], [[3wd9]], [[4myq]] - hPDE 4b catalytic domain + inhibitor<br />
+
**[[1y2h]], [[1y2j]], [[2qyl]], [[3d3p]], [[3kkt]], [[3frg]], [[3gwt]], [[3ly2]], [[3hmv]], [[3o56]], [[3o57]], [[3o0j]], [[3w5e]], [[3wd9]], [[4myq]] - hPDE 4b catalytic domain + inhibitor<br />
-
[[3g45]] - hPDE 4b catalytic domain + modulator
+
**[[3g45]] - hPDE 4b catalytic domain + modulator
-
===PDE 4c===
+
*PDE 4c
-
[[2qym]] – hPDE 4c catalytic domain
+
**[[2qym]] – hPDE 4c catalytic domain
-
===PDE 4d===
+
*PDE 4d
-
[[1e9k]] - hPDE 4d5 N terminal – NMR<BR />
+
**[[1e9k]] - hPDE 4d5 N terminal – NMR<BR />
-
[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br />
+
**[[1mkd]], [[1oyn]], [[1q9m]], [[1tbb]], [[1xoq]], [[3g4k]], [[3g4l]] - hPDE 4d catalytic domain + anti-inflammatory drug<br />
-
[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]] - hPDE 4d catalytic domain + drug<br />
+
**[[1xlx]], [[1xlz]], [[1xm4]], [[1xm6]], [[1xmu]], [[1xom]], [[1xon]], [[1xor]], [[1xos]], [[3iak]] - hPDE 4d catalytic domain + drug<br />
-
[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR />
+
**[[1ptw]], [[1tb7]] - hPDE 4d catalytic domain + AMP<BR />
-
[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR />
+
**[[2pw3]] - hPDE 4d catalytic domain (mutant) + AMP<BR />
-
[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]] - hPDE 4d catalytic domain + inhibitor<br />
+
**[[1y2b]], [[1y2c]], [[1y2d]], [[1y2e]], [[1y2k]], [[1zkn]], [[2fm0]], [[2fm5]], [[2qyn]], [[3k4s]], [[3sl3]], [[3sl4]], [[3sl5]], [[3sl6]], [[3sl8]], [[3v9b]] - hPDE 4d catalytic domain + inhibitor<br />
-
[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator
+
**[[3iad]], [[3g4g]], [[3g4i]], [[3g58]] - hPDE 4d catalytic domain + modulator
-
===PDE 5===
+
*PDE 5
-
[[2h40]] - hPDE 5a catalytic domain <BR />
+
**[[2h40]] - hPDE 5a catalytic domain <BR />
-
[[1t9r]] - hPDE 5 catalytic domain<BR />
+
**[[1t9r]] - hPDE 5 catalytic domain<BR />
-
[[2k31]] - mPDE 5a cGMP-binding domain – NMR<BR />
+
**[[2k31]] - mPDE 5a cGMP-binding domain – NMR<BR />
-
[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR />
+
**[[3lfv]], [[3mf0]], [[2xss]] - hPDE 5a GAF domain<BR />
-
[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br />
+
**[[1rkp]], [[3tgg]] – hPDE 5a1 catalytic domain (mutant) + inhibitor<br />
-
[[2chm]], [[3tse]], [[3tsf]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]] - hPDE 5a catalytic domain + inhibitor<br />
+
**[[2chm]], [[3tse]], [[3tsf]], [[4g2w]], [[4g2y]], [[4i9z]], [[4ia0]] - hPDE 5a catalytic domain + inhibitor<br />
-
[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br />
+
**[[2h44]], [[3bjc]], [[3hc8]], [[3hdz]], [[3shy]], [[3shz]], [[3sie]], [[3tge]] - hPDE 5a1 catalytic domain + inhibitor<br />
-
[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]] - hPDE 5 catalytic domain + drug<br />
+
**[[1udt]], [[1udu]], [[1uho]], [[1tbf]], [[1xoz]], [[1xp0]], [[2h42]], [[3b2r]] - hPDE 5 catalytic domain + drug<br />
-
[[3jwq]] - hPDE 5/hPDE 6 catalytic domain + drug<br />
+
**[[3jwq]] - hPDE 5/hPDE 6 catalytic domain + drug<br />
-
[[3jwr]] - hPDE 5/hPDE 6 catalytic domain + hPDE γ subunit peptide + inhibitor<br />
+
**[[3jwr]] - hPDE 5/hPDE 6 catalytic domain + hPDE γ subunit peptide + inhibitor<br />
-
[[1t9s]] - hPDE 5 catalytic domain + GMP
+
**[[1t9s]] - hPDE 5 catalytic domain + GMP
-
===PDE 6===
+
*PDE 6
-
[[3dba]] - PDE 6c cGMP-binding domain – chicken<BR />
+
**[[3dba]] - PDE 6c cGMP-binding domain – chicken<BR />
-
[[3t5g]] – hPDE 6d δ subunit + GTP-binding protein RHEB<BR />
+
**[[3t5g]] – hPDE 6d δ subunit + GTP-binding protein RHEB<BR />
-
[[3t5i]] - hPDE 6d δ subunit + GTP-binding protein RHEB peptide<br />
+
**[[3t5i]] - hPDE 6d δ subunit + GTP-binding protein RHEB peptide<br />
-
[[4jhp]] - hPDE 6d δ subunit + RPGR<br />
+
**[[4jhp]] - hPDE 6d δ subunit + RPGR<br />
-
[[4jv6]], [[4jv8]], [[4jvb]], [[4jvf]] - hPDE 6d δ subunit + inhibitor<br />
+
**[[4jv6]], [[4jv8]], [[4jvb]], [[4jvf]] - hPDE 6d δ subunit + inhibitor<br />
-
===PDE 7===
+
*PDE 7
-
[[1zkl]], [[3g3n]] – hPDE 7a catalytic domain + inhibitor<br />
+
**[[1zkl]], [[3g3n]] – hPDE 7a catalytic domain + inhibitor<br />
-
===PDE 8===
+
*PDE 8
-
[[3ecm]] – hPDE 8a catalytic domain<BR />
+
**[[3ecm]] – hPDE 8a catalytic domain<BR />
-
[[3ecn]] – hPDE 8a catalytic domain + inhibitor<br />
+
**[[3ecn]] – hPDE 8a catalytic domain + inhibitor<br />
-
===PDE 9===
+
*PDE 9
-
[[2hd1]], [[2yy2]], [[3jsi]], [[3jsw]], [[3k3e]], [[3k3h]], [[4e90]], [[4g2j]], [[4g2l]], [[4gh6]] - hPDE 6d δ subunit + RPGR<br />
+
**[[2hd1]], [[2yy2]], [[3jsi]], [[3jsw]], [[3k3e]], [[3k3h]], [[4e90]], [[4g2j]], [[4g2l]], [[4gh6]] - hPDE 6d δ subunit + RPGR<br />
-
[[3n3z]], [[3qi3]], [[3qi4]] - hPDE 9a catalytic domain (mutant) + inhibitor<br />
+
**[[3n3z]], [[3qi3]], [[3qi4]] - hPDE 9a catalytic domain (mutant) + inhibitor<br />
-
[[3dy8]], [[3dyl]], [[3dyn]], [[3dyq]], [[3dys]] - hPDE 9 catalytic domain + GMP<br />
+
**[[3dy8]], [[3dyl]], [[3dyn]], [[3dyq]], [[3dys]] - hPDE 9 catalytic domain + GMP<br />
-
[[4gyz]] - mPDE 9 catalytic domain + AMP<br />
+
**[[4gyz]] - mPDE 9 catalytic domain + AMP<br />
-
===PDE 10===
+
*PDE 10
-
[[2o8h]] – rPDE 10a catalytic domain<BR />
+
**[[2o8h]] – rPDE 10a catalytic domain<BR />
-
[[2oup]] - hPDE 10a catalytic domain<BR />
+
**[[2oup]] - hPDE 10a catalytic domain<BR />
-
[[2zmf]] – hPDE 10a C terminal<BR />
+
**[[2zmf]] – hPDE 10a C terminal<BR />
-
[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR />
+
**[[2ous]], [[2ouv]] - hPDE 10a2 catalytic domain (mutant) <BR />
-
[[2ovv]], [[2ovy]] – rPDE 10a catalytic domain + inhibitor<br />
+
**[[2ovv]], [[2ovy]] – rPDE 10a catalytic domain + inhibitor<br />
-
[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]] - hPDE 10a catalytic domain + inhibitor<br />
+
**[[2qyk]], [[3lxg]], [[2y0j]], [[3qpn]], [[3qpo]], [[3qpp]], [[3sn7]], [[3sni]], [[3snl]], [[3wi2]], [[4ael]], [[4ajd]], [[4ajf]], [[4ajg]], [[4ajm]], [[4ddl]], [[4fcb]], [[4fcd]], [[4heu]], [[4hf4]], [[4lkq]], [[4llj]], [[4llk]], [[4llp]], [[4llx]], [[4lm0]], [[4lm1]], [[4lm2]], [[4lm3]], [[4lm4]], [[4muw]], [[4mvh]] - hPDE 10a catalytic domain + inhibitor<br />
-
[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]] - hPDE 10a catalytic domain + schizophrenia drug<br />
+
**[[2wey]], [[3hqw]], [[3hqy]], [[3hqz]], [[3hr1]], [[3ui7]], [[3uuo]], [[4bbx]], [[4dff]] - hPDE 10a catalytic domain + schizophrenia drug<br />
-
[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR />
+
**[[2oun]] - hPDE 10a2 catalytic domain + AMP<BR />
-
[[2our]], [[2ouy]] - hPDE 10a2 catalytic domain (mutant) + AMP<BR />
+
**[[2our]], [[2ouy]] - hPDE 10a2 catalytic domain (mutant) + AMP<BR />
-
[[2ouq]] - hPDE 10a2 catalytic domain + GMP<BR />
+
**[[2ouq]] - hPDE 10a2 catalytic domain + GMP<BR />
-
[[2ouu]] - hPDE 10a2 catalytic domain (mutant) + GMP
+
**[[2ouu]] - hPDE 10a2 catalytic domain (mutant) + GMP
 +
*Cyclic nucleotide PDE
-
===Cyclic nucleotide PDE===
+
**[[1fsi]], [[1jh6]] – AtPDE – ''Arabidopsis thaliana''<BR />
 +
**[[1jh7]] – AtPDE + inhibitor<br />
 +
**[[1woj]] – hPDE residues 166-379<BR />
 +
**[[3jyf]] – PDE residues 16-354 – ''Klebsiella pneumonia''<br />
 +
**[[3v93]] – TcPDE catalytic domain – ''Trypanosoma cruzi''<br />
 +
**[[2ilx]] - rPDE catalytic domain<BR />
 +
**[[2xmi]], [[2y1p]], [[2y3x]] - mPDE catalytic domain <br />
 +
**[[2ydb]] - mPDE catalytic domain + cyclic NADP<br />
 +
**[[3zbr]], [[3zbs]], [[3zbz]] - mPDE catalytic domain (mutant) + NADP<br />
 +
**[[2ydc]] - mPDE catalytic domain + GTP<br />
 +
**[[2ydd]] - mPDE catalytic domain + cyclic AMP<br />
 +
**[[2ypc]], [[2ype]], [[2yph]] - mPDE catalytic domain (mutant) + cyclic AMP<br />
 +
**[[2yoz]], [[2yp0]] - mPDE catalytic domain + 2’-AMP<br />
 +
**[[2yq9]] - mPDE catalytic domain (mutant) + 2’-AMP<br />
 +
**[[1mc0]] – mPDE regulatory subunit <br />
 +
**[[3v94]] - TcPDE catalytic domain + inhibitor<br />
-
[[1fsi]], [[1jh6]] – AtPDE – ''Arabidopsis thaliana''<BR />
+
*Tyrosyl-DNA PDE
-
[[1jh7]] – AtPDE + inhibitor<br />
+
-
[[1woj]] – hPDE residues 166-379<BR />
+
-
[[3jyf]] – PDE residues 16-354 – ''Klebsiella pneumonia''<br />
+
-
[[3v93]] – TcPDE catalytic domain – ''Trypanosoma cruzi''<br />
+
-
[[2ilx]] - rPDE catalytic domain<BR />
+
-
[[2xmi]], [[2y1p]], [[2y3x]] - mPDE catalytic domain <br />
+
-
[[2ydb]] - mPDE catalytic domain + cyclic NADP<br />
+
-
[[3zbr]], [[3zbs]], [[3zbz]] - mPDE catalytic domain (mutant) + NADP<br />
+
-
[[2ydc]] - mPDE catalytic domain + GTP<br />
+
-
[[2ydd]] - mPDE catalytic domain + cyclic AMP<br />
+
-
[[2ypc]], [[2ype]], [[2yph]] - mPDE catalytic domain (mutant) + cyclic AMP<br />
+
-
[[2yoz]], [[2yp0]] - mPDE catalytic domain + 2’-AMP<br />
+
-
[[2yq9]] - mPDE catalytic domain (mutant) + 2’-AMP<br />
+
-
[[1mc0]] – mPDE regulatory subunit <br />
+
-
[[3v94]] - TcPDE catalytic domain + inhibitor<br />
+
-
===Tyrosyl-DNA PDE===
+
**[[1q32]] – yPDE – yeast<BR />
 +
**[[3sq3]], [[3sq5]], [[3sq7]], [[3sq8]] – yPDE (mutant) <BR />
 +
**[[1jy1]], [[1qzq]] – hPDE residues 149-608<BR />
 +
**[[4f1i]], [[4fva]], [[4gew]] – PDE – ''Caenorhabditis elegans''<br />
 +
**[[1mu7]] - hPDE residues 149-608 (mutant) + WO4<BR />
 +
**[[1mu9]] - hPDE residues 149-608 (mutant) + VO4<BR />
 +
**[[1nop]], [[1rff]], [[1rfi]], [[1rg1]], [[1rg2]], [[1rgt]] - hPDE residues 149-608 (mutant) + DNA + topoisomerase peptide + VO4<BR />
 +
**[[1rgu]], [[1rh0]] - hPDE residues 149-608 (mutant) + polynucleotide + neurohormone<br />
 +
**[[4f1h]], [[4fpv]] – PDE + DNA – zebra fish<br />
 +
**[[4gz0]], [[4gz1]], [[4gz2]] – mPDE + DNA<br />
-
[[1q32]] – yPDE – yeast<BR />
+
*Glycerophosphodiester PDE
-
[[3sq3]], [[3sq5]], [[3sq7]], [[3sq8]] – yPDE (mutant) <BR />
+
-
[[1jy1]], [[1qzq]] – hPDE residues 149-608<BR />
+
-
[[4f1i]], [[4fva]], [[4gew]] – PDE – ''Caenorhabditis elegans''<br />
+
-
[[1mu7]] - hPDE residues 149-608 (mutant) + WO4<BR />
+
-
[[1mu9]] - hPDE residues 149-608 (mutant) + VO4<BR />
+
-
[[1nop]], [[1rff]], [[1rfi]], [[1rg1]], [[1rg2]], [[1rgt]] - hPDE residues 149-608 (mutant) + DNA + topoisomerase peptide + VO4<BR />
+
-
[[1rgu]], [[1rh0]] - hPDE residues 149-608 (mutant) + polynucleotide + neurohormone<br />
+
-
[[4f1h]], [[4fpv]] – PDE + DNA – zebra fish<br />
+
-
[[4gz0]], [[4gz1]], [[4gz2]] – mPDE + DNA<br />
+
-
===Glycerophosphodiester PDE===
+
**[[1o1z]] – PDE – ''Thermotoga maritima''<BR />
 +
**[[1t8q]], [[1ydy]] – EcPDE <BR />
 +
**[[1v8e]] – TtPDE – ''Thermus thermophilus''<BR />
 +
**[[1vd6]] – TtPDE + glycerol<BR />
 +
**[[1zcc]] – PDE – ''Agrobacterium tumefaciens''<BR />
 +
**[[2o55]] – PDE – ''Galdieria sulphuraria''<BR />
 +
**[[2oog]], [[2p76]] – PDE – ''Staphylococcus aureus''<BR />
 +
**[[2otd]] – PDE – ''Shigella flexneri''<BR />
 +
**[[3ch0]] – PDE – ''Cytophaga hutchisonii''<BR />
 +
**[[2pz0]] – PDE – ''Thermoanaerobacter tengcongensis''<BR />
 +
**[[2zo9]], [[2zoa]] – PDE + malonate – ''Enterobacter aerogenes''<BR />
 +
**[[3mz2]], [[3no3]] – PDE – ''Parabacterioides distasonia''<BR />
-
[[1o1z]] – PDE – ''Thermotoga maritima''<BR />
+
*C-di-GMP PDE See [[C-di-GMP phosphodiesterase]]
-
[[1t8q]], [[1ydy]] – EcPDE <BR />
+
-
[[1v8e]] – TtPDE – ''Thermus thermophilus''<BR />
+
-
[[1vd6]] – TtPDE + glycerol<BR />
+
-
[[1zcc]] – PDE – ''Agrobacterium tumefaciens''<BR />
+
-
[[2o55]] – PDE – ''Galdieria sulphuraria''<BR />
+
-
[[2oog]], [[2p76]] – PDE – ''Staphylococcus aureus''<BR />
+
-
[[2otd]] – PDE – ''Shigella flexneri''<BR />
+
-
[[3ch0]] – PDE – ''Cytophaga hutchisonii''<BR />
+
-
[[2pz0]] – PDE – ''Thermoanaerobacter tengcongensis''<BR />
+
-
[[2zo9]], [[2zoa]] – PDE + malonate – ''Enterobacter aerogenes''<BR />
+
-
[[3mz2]], [[3no3]] – PDE – ''Parabacterioides distasonia''<BR />
+
-
===C-di-GMP PDE===
+
*PDE
-
 
+
-
See [[C-di-GMP phosphodiesterase]]
+
-
 
+
-
[[2ahd]] – PDE – ''Methanocaldococcus jannaschii''<BR />
+
-
[[3qvq]] – PDE + glycerol-3-phosphate – ''Oleispira antarctica''<br />
+
-
[[4b2o]] – PDE – ''Bacillus subtilis''<br />
+
-
[[4g75]], [[4g76]] – PDE – ''Pseudomonas aeruginosa''<br />
+
 +
**[[2ahd]] – PDE – ''Methanocaldococcus jannaschii''<BR />
 +
**[[3qvq]] – PDE + glycerol-3-phosphate – ''Oleispira antarctica''<br />
 +
**[[4b2o]] – PDE – ''Bacillus subtilis''<br />
 +
**[[4g75]], [[4g76]] – PDE – ''Pseudomonas aeruginosa''<br />
 +
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:31, 3 December 2014

Template:STRUCTURE 3g45

  • 3'5'-cyclic nucleotide phosphodiesterases (PDE) are enzymes that hydrolyze the 3',5'-phosphodiester bond in cyclic nucleotides (e.g., cAMP, cGMP). PDEs operate in concert with cyclases (adenylate cyclase or guanylate cyclase) to regulate the cellular concentration of cyclic nucleotides. cAMP and cGMP serve as intracellular second messengers for a multitude of signaling pathways, including sensory transduction, hormone signaling, and neurotransmitter signaling. In mammals, 11 distinct families of PDEs have been identified which share a highly homologous catalytic domain (pfam:00233, PDEase_I). See details on PDE 6 in User:Rick H. Cote/PDE6.
  • Tyrosyl-DNA PDE hydrolyzes phosphodiester bond at the 3’-end of DNA linked to a tyrosyl moiety.
  • Glycerophosphodiester PDE hydrolyzes various glycerophosphodiesters to release glycerol-3-phosphate and alcohol.

Specific phosphodiesterases are in C-di-GMP specific phosphodiesterases.

3D Structures of phosphodiesterase

Updated on 03-December-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Rick H. Cote

Retrieved from "http://52.214.119.220/wiki/index.php/Phosphodiesterase"
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