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Phosphodiesterase
From Proteopedia
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**[[3mz2]], [[3no3]] – PDE – ''Parabacterioides distasonia''<BR /> | **[[3mz2]], [[3no3]] – PDE – ''Parabacterioides distasonia''<BR /> | ||
| - | *C-di-GMP PDE See [[C-di-GMP phosphodiesterase]] | + | *C-di-GMP PDE See [[C-di-GMP specific phosphodiesterase]] |
*PDE | *PDE | ||
Revision as of 07:31, 3 December 2014
- 3'5'-cyclic nucleotide phosphodiesterases (PDE) are enzymes that hydrolyze the 3',5'-phosphodiester bond in cyclic nucleotides (e.g., cAMP, cGMP). PDEs operate in concert with cyclases (adenylate cyclase or guanylate cyclase) to regulate the cellular concentration of cyclic nucleotides. cAMP and cGMP serve as intracellular second messengers for a multitude of signaling pathways, including sensory transduction, hormone signaling, and neurotransmitter signaling. In mammals, 11 distinct families of PDEs have been identified which share a highly homologous catalytic domain (pfam:00233, PDEase_I). See details on PDE 6 in User:Rick H. Cote/PDE6.
- Tyrosyl-DNA PDE hydrolyzes phosphodiester bond at the 3’-end of DNA linked to a tyrosyl moiety.
- Glycerophosphodiester PDE hydrolyzes various glycerophosphodiesters to release glycerol-3-phosphate and alcohol.
Specific phosphodiesterases are in C-di-GMP specific phosphodiesterases.
3D Structures of phosphodiesterase
Updated on 03-December-2014
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Rick H. Cote
