1mco
From Proteopedia
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| - | [[Image:1mco.jpg|left|200px]] | + | [[Image:1mco.jpg|left|200px]] |
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| - | '''THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION''' | + | {{Structure |
| + | |PDB= 1mco |SIZE=350|CAPTION= <scene name='initialview01'>1mco</scene>, resolution 3.2Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MCO is a [ | + | 1MCO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MCO OCA]. |
==Reference== | ==Reference== | ||
| - | Three-dimensional structure of a human immunoglobulin with a hinge deletion., Guddat LW, Herron JN, Edmundson AB, Proc Natl Acad Sci U S A. 1993 May 1;90(9):4271-5. PMID:[http:// | + | Three-dimensional structure of a human immunoglobulin with a hinge deletion., Guddat LW, Herron JN, Edmundson AB, Proc Natl Acad Sci U S A. 1993 May 1;90(9):4271-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8483943 8483943] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:41:53 2008'' |
Revision as of 10:41, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
THREE-DIMENSIONAL STRUCTURE OF A HUMAN IMMUNOGLOBULIN WITH A HINGE DELETION
Overview
X-ray analysis at 3.2-A resolution revealed that the Mcg IgG1 (lambda chain) immunoglobulin is a compact T-shaped molecule. Because of the hinge deletion, the Fc fragment lobe is pulled tightly upward into the junction of the Fab arms. Along the molecular twofold axis, the Fab arms are joined by an interchain disulfide bond between the two light chains. The antigen combining sites consist of large irregular cavities at the tips of the Fab regions. Potential complement (C1q) binding sites on Fc are sterically shielded by the Fab arms, but putative attachment sites are accessible for docking with the FcRI receptor on human monocytes and with protein A of Staphylococcus aureus.
About this Structure
1MCO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of a human immunoglobulin with a hinge deletion., Guddat LW, Herron JN, Edmundson AB, Proc Natl Acad Sci U S A. 1993 May 1;90(9):4271-5. PMID:8483943
Page seeded by OCA on Thu Mar 20 12:41:53 2008
