1mdg
From Proteopedia
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| - | [[Image:1mdg.gif|left|200px]] | + | [[Image:1mdg.gif|left|200px]] |
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| - | '''An Alternating Antiparallel Octaplex in an RNA Crystal Structure''' | + | {{Structure |
| + | |PDB= 1mdg |SIZE=350|CAPTION= <scene name='initialview01'>1mdg</scene>, resolution 1.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=NCO:COBALT HEXAMMINE ION'>NCO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''An Alternating Antiparallel Octaplex in an RNA Crystal Structure''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MDG is a [ | + | 1MDG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MDG OCA]. |
==Reference== | ==Reference== | ||
| - | An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Jul;11(7):825-31. PMID:[http:// | + | An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Jul;11(7):825-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12842045 12842045] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Pan, B C.]] | [[Category: Pan, B C.]] | ||
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[[Category: NA]] | [[Category: NA]] | ||
[[Category: NCO]] | [[Category: NCO]] | ||
| - | [[Category: base | + | [[Category: base octad]] |
| - | [[Category: base | + | [[Category: base tetrad]] |
[[Category: rna]] | [[Category: rna]] | ||
[[Category: tetraplex]] | [[Category: tetraplex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:42:09 2008'' |
Revision as of 10:42, 20 March 2008
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| , resolution 1.50Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
An Alternating Antiparallel Octaplex in an RNA Crystal Structure
Overview
Multistranded helical structures in nucleic acids play various functions in biological processes. Here we report the crystal structure of a hexamer, rU(BrdG)r(AGGU),at 1.5 A resolution containing a structural complex of an alternating antiparallel eight-stranded helical fragment that is sandwiched in two tetraplexes. The octaplex is formed by groove binding interaction and base tetrad intercalation between two tetraplexes. Two different forms of octaplexes have been proposed, which display different properties in interaction with proteins and nucleic acids. Adenines form a base tetrad in the novel N6-H em leader N3 conformation and further interact with uridines to form an adenine-uridine octad in the reverse Hoogsteen pairing scheme. The conformational flexibility of adenine tetrad indicates that it can optimize its conformation in different interactions.
About this Structure
1MDG is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Jul;11(7):825-31. PMID:12842045
Page seeded by OCA on Thu Mar 20 12:42:09 2008
Categories: Protein complex | Pan, B C. | Shi, K. | Sundaralingam, M. | Xiong, Y. | NA | NCO | Base octad | Base tetrad | Rna | Tetraplex
