1mek
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1mek.gif|left|200px]] | + | [[Image:1mek.gif|left|200px]] |
| - | + | ||
| - | '''HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES''' | + | {{Structure |
| + | |PDB= 1mek |SIZE=350|CAPTION= <scene name='initialview01'>1mek</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1MEK is a [ | + | 1MEK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEK OCA]. |
==Reference== | ==Reference== | ||
| - | Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy., Kemmink J, Darby NJ, Dijkstra K, Nilges M, Creighton TE, Biochemistry. 1996 Jun 18;35(24):7684-91. PMID:[http:// | + | Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy., Kemmink J, Darby NJ, Dijkstra K, Nilges M, Creighton TE, Biochemistry. 1996 Jun 18;35(24):7684-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8672469 8672469] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein disulfide-isomerase]] | [[Category: Protein disulfide-isomerase]] | ||
| Line 24: | Line 33: | ||
[[Category: redox-active center]] | [[Category: redox-active center]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:42:30 2008'' |
Revision as of 10:42, 20 March 2008
| |||||||
| Activity: | Protein disulfide-isomerase, with EC number 5.3.4.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES
Overview
As a first step in dissecting the structure of human protein disulfide isomerase (PDI), the structure of a fragment corresponding to the first 120 residues of its sequence has been determined using heteronuclear multidimensional NMR techniques. As expected from its primary structure homology, the fragment has the thioredoxin fold. Similarities and differences in their structures help to explain why thioredoxins are reductants, whereas PDI is an oxidant of protein thiol groups. The results confirm that PDI has a modular, multidomain structure, which will facilitate its structural and functional characterization.
About this Structure
1MEK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure determination of the N-terminal thioredoxin-like domain of protein disulfide isomerase using multidimensional heteronuclear 13C/15N NMR spectroscopy., Kemmink J, Darby NJ, Dijkstra K, Nilges M, Creighton TE, Biochemistry. 1996 Jun 18;35(24):7684-91. PMID:8672469
Page seeded by OCA on Thu Mar 20 12:42:30 2008
