2wvp
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==SYNTHETICALLY MODIFIED OMPG== |
| + | <StructureSection load='2wvp' size='340' side='right' caption='[[2wvp]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2wvp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WVP FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=420:N-[2-({[5-(DIMETHYLAMINO)NAPHTHALEN-1-YL]SULFONYL}AMINO)ETHYL]-2-IODOACETAMIDE'>420</scene>, <scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f1c|2f1c]], [[2iww|2iww]], [[2iwv|2iwv]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wvp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wvp RCSB], [http://www.ebi.ac.uk/pdbsum/2wvp PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wv/2wvp_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Chemical modification of ion channels has recently attracted attention due to their potential use in stochastic sensing and neurobiology. Among the available channel templates stable beta-barrel proteins have shown their potential for large scale chemical modifications due to their wide pore lumen. Ion-channel hybrids using the outer membrane protein OmpG were generated by S-alkylation with a synthetic modulator and functionally as well as structurally characterized. The dansyl moiety of the used modulator resulted in partial blockage of current though the OmpG channel with its gating characteristics mainly unaffected. The crystal structure of an OmpG-dansyl hybrid at 2.4A resolution correlates this finding by showing that the modulator lines the inner walling of the OmpG pore. These results underline the suitability of OmpG as a structural base for the construction of stochastic sensors. | ||
| - | + | Structural and functional characterization of a synthetically modified OmpG.,Grosse W, Reiss P, Reitz S, Cebi M, Lubben W, Koert U, Essen LO Bioorg Med Chem. 2010 Mar 25. PMID:20378361<ref>PMID:20378361</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Cebi, M | + | [[Category: Cebi, M]] |
| - | [[Category: Essen, L O | + | [[Category: Essen, L O]] |
| - | [[Category: Grosse, W | + | [[Category: Grosse, W]] |
| - | [[Category: Koert, U | + | [[Category: Koert, U]] |
| - | [[Category: Luebben, W | + | [[Category: Luebben, W]] |
| - | [[Category: Reiss, P | + | [[Category: Reiss, P]] |
| - | [[Category: Reitz, S | + | [[Category: Reitz, S]] |
[[Category: Ion-channel engineering]] | [[Category: Ion-channel engineering]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Ompg hybrid]] | [[Category: Ompg hybrid]] | ||
Revision as of 10:11, 3 December 2014
SYNTHETICALLY MODIFIED OMPG
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