2l6i
From Proteopedia
(Difference between revisions)
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| - | [[ | + | ==Solution structure of coronaviral stem-loop 2 (SL2)== |
| + | <StructureSection load='2l6i' size='340' side='right' caption='[[2l6i]], [[NMR_Ensembles_of_Models | 27 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2l6i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L6I FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l6i RCSB], [http://www.ebi.ac.uk/pdbsum/2l6i PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed. | ||
| - | + | The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold.,Lee CW, Li L, Giedroc DP FEBS Lett. 2011 Mar 4. PMID:21382373<ref>PMID:21382373</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Giedroc, D P]] | |
| - | == | + | [[Category: Lee, C]] |
| - | < | + | [[Category: Li, L]] |
| - | [[Category: Giedroc, D P | + | |
| - | [[Category: Lee, C | + | |
| - | [[Category: Li, L | + | |
[[Category: Coronavirus]] | [[Category: Coronavirus]] | ||
[[Category: Mouse hepatitis virus]] | [[Category: Mouse hepatitis virus]] | ||
Revision as of 10:11, 3 December 2014
Solution structure of coronaviral stem-loop 2 (SL2)
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