1mfe

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[[Image:1mfe.gif|left|200px]]<br /><applet load="1mfe" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mfe.gif|left|200px]]
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caption="1mfe, resolution 2.0&Aring;" />
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'''RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT'''<br />
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{{Structure
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|PDB= 1mfe |SIZE=350|CAPTION= <scene name='initialview01'>1mfe</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MFE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFE OCA].
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1MFE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MFE OCA].
==Reference==
==Reference==
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Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment., Cygler M, Rose DR, Bundle DR, Science. 1991 Jul 26;253(5018):442-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1713710 1713710]
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Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment., Cygler M, Rose DR, Bundle DR, Science. 1991 Jul 26;253(5018):442-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1713710 1713710]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Cygler, M.]]
[[Category: Cygler, M.]]
[[Category: immunoglobulin]]
[[Category: immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:54:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:42:50 2008''

Revision as of 10:42, 20 March 2008

Image:1mfe.gif


PDB ID 1mfe

Drag the structure with the mouse to rotate
, resolution 2.0Å
Coordinates: save as pdb, mmCIF, xml



RECOGNITION OF A CELL-SURFACE OLIGO-SACCHARIDE OF PATHOGENIC SALMONELLA BY AN ANTIBODY FAB FRAGMENT


Overview

The 2.05 angstrom (A) resolution crystal structure of a dodecasaccharide-Fab complex revealed an unusual carbohydrate recognition site, defined by aromatic amino acids and a structured water molecule, rather than the carboxylic acid and amide side chains and a structured water molecule, rather than the carboxylic acid and amide side chains that are features of transport and other carbohydrate binding proteins. A trisaccharide epitope of a branched bacterial lipopolysaccharide fills this hydrophobic pocket (8 A deep by 7 A wide) in an entropy-assisted association (association constant = 2.05 x 10(5) liters per mole, enthalpy = -20.5 +/- 1.7 kilojoules per mole, and temperature times entropy = +10.0 +/- 2.9 kilojoules per mole). The requirement for the complementarity of van der Waals surfaces and the requirements of saccharide-saccharide and protein-saccharide hydrogen-bonding networks determine the antigen conformation adopted in the bound state.

About this Structure

1MFE is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment., Cygler M, Rose DR, Bundle DR, Science. 1991 Jul 26;253(5018):442-5. PMID:1713710

Page seeded by OCA on Thu Mar 20 12:42:50 2008

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