1mhd

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[[Image:1mhd.gif|left|200px]]<br /><applet load="1mhd" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mhd.gif|left|200px]]
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caption="1mhd, resolution 2.8&Aring;" />
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'''CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA'''<br />
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{{Structure
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|PDB= 1mhd |SIZE=350|CAPTION= <scene name='initialview01'>1mhd</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= SMAD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MHD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHD OCA].
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1MHD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHD OCA].
==Reference==
==Reference==
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Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling., Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP, Cell. 1998 Sep 4;94(5):585-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9741623 9741623]
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Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling., Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP, Cell. 1998 Sep 4;94(5):585-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9741623 9741623]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: smad3 mh1]]
[[Category: smad3 mh1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:55:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:43:24 2008''

Revision as of 10:43, 20 March 2008

Image:1mhd.gif


PDB ID 1mhd

Drag the structure with the mouse to rotate
, resolution 2.8Å
Gene: SMAD (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF A SMAD MH1 DOMAIN BOUND TO DNA


Overview

The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-beta signaling from cell membrane to nucleus. The crystal structure of a Smad3 MH1 domain bound to an optimal DNA sequence determined at 2.8 A resolution reveals a novel DNA-binding motif. In the crystals, base-specific DNA recognition is provided exclusively by a conserved 11-residue beta hairpin that is embedded in the major groove of DNA. A surface loop region, to which tumorigenic mutations map, has been identified as a functional surface important for Smad activity. This structure establishes a framework for understanding how Smad proteins may act in concert with other transcription factors in the regulation of TGF-beta-responsive genes.

About this Structure

1MHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling., Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP, Cell. 1998 Sep 4;94(5):585-94. PMID:9741623

Page seeded by OCA on Thu Mar 20 12:43:24 2008

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