3gdd
From Proteopedia
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| - | [[ | + | ==An inverted anthraquinone-DNA crystal structure== |
| + | <StructureSection load='3gdd' size='340' side='right' caption='[[3gdd]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3gdd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GDD FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5BD:N,N-(9,10-DIOXO-9,10-DIHYDROANTHRACENE-2,7-DIYL)BIS[2-(DIMETHYLAMINO)ACETAMIDE]'>5BD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gdd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gdd RCSB], [http://www.ebi.ac.uk/pdbsum/3gdd PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G.G and A.UBr reverse Watson-Crick base pairs. | ||
| - | + | Structure of a stacked anthraquinone-DNA complex.,De Luchi D, Uson I, Wright G, Gouyette C, Subirana JA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Sep 1;66(Pt, 9):1019-22. Epub 2010 Aug 21. PMID:20823516<ref>PMID:20823516</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Gouyette, C]] | |
| - | == | + | [[Category: Luchi, D De]] |
| - | < | + | [[Category: Subirana, J A]] |
| - | [[Category: Gouyette, C | + | [[Category: Wright, G]] |
| - | [[Category: Luchi, D De | + | |
| - | [[Category: Subirana, J A | + | |
| - | [[Category: Wright, G | + | |
[[Category: Anthraquinone]] | [[Category: Anthraquinone]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: Drug-dna complex]] | [[Category: Drug-dna complex]] | ||
[[Category: Telomere dna sequence]] | [[Category: Telomere dna sequence]] | ||
Revision as of 10:24, 3 December 2014
An inverted anthraquinone-DNA crystal structure
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