1mhs

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[[Image:1mhs.gif|left|200px]]<br /><applet load="1mhs" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1mhs.gif|left|200px]]
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caption="1mhs, resolution 8.0&Aring;" />
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'''Model of Neurospora crassa proton ATPase'''<br />
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{{Structure
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|PDB= 1mhs |SIZE=350|CAPTION= <scene name='initialview01'>1mhs</scene>, resolution 8.0&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Proton-exporting_ATPase Proton-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.6 3.6.3.6]
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|GENE=
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}}
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'''Model of Neurospora crassa proton ATPase'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1MHS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Active as [http://en.wikipedia.org/wiki/Proton-exporting_ATPase Proton-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.6 3.6.3.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHS OCA].
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1MHS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MHS OCA].
==Reference==
==Reference==
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Structure, mechanism, and regulation of the Neurospora plasma membrane H+-ATPase., Kuhlbrandt W, Zeelen J, Dietrich J, Science. 2002 Sep 6;297(5587):1692-6. Epub 2002 Aug 8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12169656 12169656]
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Structure, mechanism, and regulation of the Neurospora plasma membrane H+-ATPase., Kuhlbrandt W, Zeelen J, Dietrich J, Science. 2002 Sep 6;297(5587):1692-6. Epub 2002 Aug 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12169656 12169656]
[[Category: Neurospora crassa]]
[[Category: Neurospora crassa]]
[[Category: Proton-exporting ATPase]]
[[Category: Proton-exporting ATPase]]
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[[Category: proton pump]]
[[Category: proton pump]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:55:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:43:33 2008''

Revision as of 10:43, 20 March 2008

Image:1mhs.gif


PDB ID 1mhs

Drag the structure with the mouse to rotate
, resolution 8.0Å
Activity: Proton-exporting ATPase, with EC number 3.6.3.6
Coordinates: save as pdb, mmCIF, xml



Model of Neurospora crassa proton ATPase


Overview

Proton pumps in the plasma membrane of plants and yeasts maintain the intracellular pH and membrane potential. To gain insight into the molecular mechanisms of proton pumping, we built an atomic homology model of the proton pump based on the 2.6 angstrom x-ray structure of the related Ca2+ pump from rabbit sarcoplasmic reticulum. The model, when fitted to an 8 angstrom map of the Neurospora proton pump determined by electron microscopy, reveals the likely path of the proton through the membrane and shows that the nucleotide-binding domain rotates by approximately 70 degrees to deliver adenosine triphosphate (ATP) to the phosphorylation site. A synthetic peptide corresponding to the carboxyl-terminal regulatory domain stimulates ATPase activity, suggesting a mechanism for proton transport regulation.

About this Structure

1MHS is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

Structure, mechanism, and regulation of the Neurospora plasma membrane H+-ATPase., Kuhlbrandt W, Zeelen J, Dietrich J, Science. 2002 Sep 6;297(5587):1692-6. Epub 2002 Aug 8. PMID:12169656

Page seeded by OCA on Thu Mar 20 12:43:33 2008

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